CD86_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD86_HUMAN
• UniProt AC: P42081
• Protein Name: T-lymphocyte activation antigen CD86
• Gene Name: CD86
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B..
• Protein Sequence: MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	LKIQAYFNETADLPC CEEHHHHCCCCCCCC	32.79	UniProtKB CARBOHYD
47	N-linked_Glycosylation	CQFANSQNQSLSELV CCCCCCCCCCHHHEE	32.98	UniProtKB CARBOHYD
77	Phosphorylation	LGKEKFDSVHSKYMG CCHHHCCCCCHHHCC	25.51	-
80	Phosphorylation	EKFDSVHSKYMGRTS HHCCCCCHHHCCCCC	24.27	-
108	Phosphorylation	QIKDKGLYQCIIHHK EECCCEEEEEEEECC	15.26	25884760
135	N-linked_Glycosylation	SELSVLANFSQPEIV HHHEEEECCCCCEEE	32.70	UniProtKB CARBOHYD
146	N-linked_Glycosylation	PEIVPISNITENVYI CEEEECCCCCCCEEE	46.01	UniProtKB CARBOHYD
154	N-linked_Glycosylation	ITENVYINLTCSSIH CCCCEEEEEEEEHHC	16.17	UniProtKB CARBOHYD
175	Phosphorylation	KMSVLLRTKNSTIEY EEEEEEECCCCEEEE	34.25	22496350
177	N-linked_Glycosylation	SVLLRTKNSTIEYDG EEEEECCCCEEEECC	43.71	UniProtKB CARBOHYD
192	N-linked_Glycosylation	VMQKSQDNVTELYDV EEECCCCCCEEEEEE	34.67	UniProtKB CARBOHYD
213	N-linked_Glycosylation	SFPDVTSNMTIFCIL ECCCCCCCEEEEEEE	23.42	UniProtKB CARBOHYD
223 (in isoform 4)	Phosphorylation	-	40.74	-
224 (in isoform 4)	Phosphorylation	-	42.86	-
227 (in isoform 4)	Phosphorylation	-	7.05	-
230 (in isoform 4)	Phosphorylation	-	29.90	-
284	Phosphorylation	RNSYKCGTNTMEREE CCCCCCCCCHHCHHH	36.67	27486199
286	Phosphorylation	SYKCGTNTMEREESE CCCCCCCHHCHHHHH	21.90	27486199
292	Phosphorylation	NTMEREESEQTKKRE CHHCHHHHHHHHHHH	30.19	27486199
295	Phosphorylation	EREESEQTKKREKIH CHHHHHHHHHHHHCC	34.19	27486199
315	Acetylation	DEAQRVFKSSKTSSC HHHHHHHHCCCCCCC	51.46	7971967
316	Phosphorylation	EAQRVFKSSKTSSCD HHHHHHHCCCCCCCC	26.13	30108239
317	Phosphorylation	AQRVFKSSKTSSCDK HHHHHHCCCCCCCCC	40.31	30108239
319	Phosphorylation	RVFKSSKTSSCDKSD HHHHCCCCCCCCCCC	28.02	30108239
320	Phosphorylation	VFKSSKTSSCDKSDT HHHCCCCCCCCCCCC	32.48	30108239
321	Phosphorylation	FKSSKTSSCDKSDTC HHCCCCCCCCCCCCC	31.41	30108239
325	Phosphorylation	KTSSCDKSDTCF--- CCCCCCCCCCCC---	25.54	30108239
327	Phosphorylation	SSCDKSDTCF----- CCCCCCCCCC-----	23.93	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF1	Q8TCQ1	PMID:21220452
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF8	Q5T0T0	PMID:12582153
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF2	Q9P0N8	PMID:14722266
-	K	Ubiquitination	E3 ubiquitin ligase	K5	P90489	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD86_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD86_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARH1_HUMAN	MARCH1	physical	21896490
PARP1_HUMAN	PARP1	physical	21988832
CTLA4_HUMAN	CTLA4	physical	25241761
CD80_HUMAN	CD80	physical	25241761

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D03203: Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN); Orencia (TN)
• DrugBank
• There are no disease associations of PTM sites.