CD80_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD80_HUMAN
• UniProt AC: P33681
• Protein Name: T-lymphocyte activation antigen CD80
• Gene Name: CD80
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B..
• Protein Sequence: MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	ATLSCGHNVSVEELA EEEECCCCCCHHHHH	17.03	11279502
89	N-linked_Glycosylation	NIWPEYKNRTIFDIT CCCHHHCCCEEEECC	45.48	11279502
98	N-linked_Glycosylation	TIFDITNNLSIVILA EEEECCCCEEEEEEE	26.90	UniProtKB CARBOHYD
114	Phosphorylation	RPSDEGTYECVVLKY CCCCCCEEEEEEEEE	20.42	25849741
186	N-linked_Glycosylation	GEELNAINTTVSQDP CCEECCCEEEECCCC	27.56	11279502
207	N-linked_Glycosylation	VSSKLDFNMTTNHSF EEECCCCCCCCCCEE	26.93	11279502
211	N-linked_Glycosylation	LDFNMTTNHSFMCLI CCCCCCCCCEEEEEE	21.46	UniProtKB CARBOHYD
219	Acetylation	HSFMCLIKYGHLRVN CEEEEEEEECEEEEC	32.03	12655207
226	N-linked_Glycosylation	KYGHLRVNQTFNWNT EECEEEECEEECCCC	28.83	11279502
232	N-linked_Glycosylation	VNQTFNWNTTKQEHF ECEEECCCCCCCHHC	38.69	UniProtKB CARBOHYD
284	Phosphorylation	NERLRRESVRPV--- HHHHHHHHCCCC---	22.93	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD80_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD80_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD80_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD80_HUMAN	CD80	physical	11279502
CTLA4_HUMAN	CTLA4	physical	11279502
TNR16_HUMAN	NGFR	physical	21982860
PD1L1_HUMAN	CD274	physical	21982860
CD28_HUMAN	CD28	physical	21982860
CTLA4_HUMAN	CTLA4	physical	21982860

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D03203: Abatacept (genetical recombination) (JAN); Abatacept (USAN/INN); Orencia (TN)
• D04295: Galiximab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.