PDPK1_DROME - dbPTM
PDPK1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDPK1_DROME
UniProt AC Q9W0V1
Protein Name 3-phosphoinositide-dependent protein kinase 1
Gene Name Pdk1
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 836
Subcellular Localization Cytoplasm.
Protein Description Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis..
Protein Sequence MKCKSWSNKINNYVVRKIKSIKINGTQQQLQLPGSGASGIAAAAVITVASDCGENCSSNGTEHQQHFNIATTTATSATEATMPAMAKEKASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLEQQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYGDPSSTSAVSCSSGSSNSLAVISNSSAASSSNSPTVKRSSPVNAPQASTASDNRTLGSTRTGTSPSKKTASK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
140PhosphorylationSTENNNNSRYGSSKY
CCCCCCCCCCCCCEE
29.0621082442
180PhosphorylationCRMLHNCSLQQYQND
HHHHHCCCHHHHHHH
34.2321082442
624PhosphorylationRQISRLLSAELGVGS
HHHHHHHHHHHCCCC
25.0421082442
641PhosphorylationAMPVKRSTAKNSFDL
EEECCCCCCCCCCCC
45.7622817900
645PhosphorylationKRSTAKNSFDLNDAE
CCCCCCCCCCCCHHH
21.3019429919
803PhosphorylationNSPTVKRSSPVNAPQ
CCCCCCCCCCCCCCC
33.0221082442
804PhosphorylationSPTVKRSSPVNAPQA
CCCCCCCCCCCCCCC
36.5810336630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDPK1_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDPK1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDPK1_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPT2_DROMECG5815physical
14605208
MS57A_DROMEMst57Daphysical
14605208
AKT1_DROMEAkt1genetic
11344272
AKT1_DROMEAkt1genetic
11752451
2AAA_DROMEPp2A-29Bphysical
27626673
RS6_DROMERpS6physical
27626673
HSP7C_DROMEHsc70-3physical
27626673
KC1A_DROMECkIalphaphysical
27626673
CLH_DROMEChcphysical
27626673
IF2A_DROMEeIF-2alphaphysical
27626673
PRS8_DROMERpt6physical
27626673
RLA1_DROMERpLP1physical
27626673
EIF3I_DROMETrip1physical
27626673
IF4A_DROMEeIF-4aphysical
27626673
GBLP_DROMERack1physical
27626673
RL9_DROMERpL9physical
27626673
NFS1_DROMECG12264physical
27626673
RS26_DROMERpS26physical
27626673
MET13_DROMECG2614physical
27626673
RL31_DROMERpL31physical
27626673
RS11_DROMERpS11physical
27626673
EIF3M_DROMETango7physical
27626673
RS23_DROMERpS23physical
27626673
CLU_DROMEcluphysical
27626673
RL18A_DROMERpL18Aphysical
27626673
EIF3C_DROMEeIF3-S8physical
27626673
ACT3_DROMEAct57Bphysical
27626673
DCAF1_DROMEmahjphysical
27626673
RS16_DROMERpS16physical
27626673
FBRL_DROMEFibphysical
27626673
TBB3_DROMEbetaTub60Dphysical
27626673
RL28_DROMERpL28physical
27626673
ACADM_DROMECG12262physical
27626673
RS17_DROMERpS17physical
27626673
RS9_DROMERpS9physical
27626673
AGO2_DROMEAGO2physical
27626673
EIF3A_DROMEeIF3-S10physical
27626673
RFC1_DROMEGnf1physical
27626673
RL13A_DROMERpL13Aphysical
27626673
DDX17_DROMERm62physical
27626673
SQD_DROMEsqdphysical
27626673
TCPA_DROMET-cp1physical
27626673
PRS4_DROMERpt2physical
27626673
NCD_DROMEncdphysical
27626673
RS7_DROMERpS7physical
27626673
RL10_DROMERpL10physical
27626673
RS15A_DROMERpS15Aaphysical
27626673
RL8_DROMERpL8physical
27626673
METK_DROMESam-Sphysical
27626673
TID_DROMEl(2)tidphysical
27626673
ATC1_DROMECa-P60Aphysical
27626673
ANKHM_DROMEmaskphysical
27626673
LARP_DROMElarpphysical
27626673

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDPK1_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-641; SER-645 ANDSER-804, AND MASS SPECTROMETRY.

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