UniProt ID | PDPK1_DROME | |
---|---|---|
UniProt AC | Q9W0V1 | |
Protein Name | 3-phosphoinositide-dependent protein kinase 1 | |
Gene Name | Pdk1 | |
Organism | Drosophila melanogaster (Fruit fly). | |
Sequence Length | 836 | |
Subcellular Localization | Cytoplasm. | |
Protein Description | Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.. | |
Protein Sequence | MKCKSWSNKINNYVVRKIKSIKINGTQQQLQLPGSGASGIAAAAVITVASDCGENCSSNGTEHQQHFNIATTTATSATEATMPAMAKEKASATVSLGESNFRDINLKDLAVVVEAASRLHHQQNVCGCGAVSSTENNNNSRYGSSKYLTNGHTSPLAAAVASNSSSVATTPHCRMLHNCSLQQYQNDIRQQTEILDMLRQQHQQGYQSQQQQQQPQQQQEQQQQQEQSQQQQQLQNPAPRRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYDRDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITPAADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILDCAVDFPQGFDKDAEDLVRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDEDFRSSYTVPGDLEPGLDERQISRLLSAELGVGSSVAMPVKRSTAKNSFDLNDAEKLQRLEQQKTDKWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLIYIDPVQMIKKGEIPWSPDLRAEYKNFKIFFVHTPNRTYYLDDPEGYAIHWSEAIENMRKLAYGDPSSTSAVSCSSGSSNSLAVISNSSAASSSNSPTVKRSSPVNAPQASTASDNRTLGSTRTGTSPSKKTASK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
140 | Phosphorylation | STENNNNSRYGSSKY CCCCCCCCCCCCCEE | 29.06 | 21082442 | |
180 | Phosphorylation | CRMLHNCSLQQYQND HHHHHCCCHHHHHHH | 34.23 | 21082442 | |
624 | Phosphorylation | RQISRLLSAELGVGS HHHHHHHHHHHCCCC | 25.04 | 21082442 | |
641 | Phosphorylation | AMPVKRSTAKNSFDL EEECCCCCCCCCCCC | 45.76 | 22817900 | |
645 | Phosphorylation | KRSTAKNSFDLNDAE CCCCCCCCCCCCHHH | 21.30 | 19429919 | |
803 | Phosphorylation | NSPTVKRSSPVNAPQ CCCCCCCCCCCCCCC | 33.02 | 21082442 | |
804 | Phosphorylation | SPTVKRSSPVNAPQA CCCCCCCCCCCCCCC | 36.58 | 10336630 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PDPK1_DROME !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PDPK1_DROME !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PDPK1_DROME !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-641; SER-645 ANDSER-804, AND MASS SPECTROMETRY. |