| UniProt ID | GBRE_HUMAN | |
|---|---|---|
| UniProt AC | P78334 | |
| Protein Name | Gamma-aminobutyric acid receptor subunit epsilon | |
| Gene Name | GABRE | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 506 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. | |
| Protein Sequence | MLSKVLPVLLGILLILQSRVEGPQTESKNEASSRDVVYGPQPQPLENQLLSEETKSTETETGSRVGKLPEASRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWLVCLNL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 82 | Phosphorylation | LNTILSNYDHKLRPG HHHHHHHCCCCCCCC | 18.95 | 29978859 | |
| 134 | N-linked_Glycosylation | YDERLCYNDTFESLV CCCCEECCCCCHHHE | 40.63 | UniProtKB CARBOHYD | |
| 163 | Phosphorylation | FFRNSKRTHEHEITM CCCCCCCCEEEEECC | 35.04 | - | |
| 169 | Phosphorylation | RTHEHEITMPNQMVR CCEEEEECCCCCEEE | 24.48 | 24719451 | |
| 178 | Phosphorylation | PNQMVRIYKDGKVLY CCCEEEEEECCEEEE | 7.77 | - | |
| 185 | Phosphorylation | YKDGKVLYTIRMTID EECCEEEEEEEEEEE | 11.78 | 26552605 | |
| 186 | Phosphorylation | KDGKVLYTIRMTIDA ECCEEEEEEEEEEEC | 9.65 | 24719451 | |
| 190 | Phosphorylation | VLYTIRMTIDAGCSL EEEEEEEEEECCCEE | 13.07 | 26552605 | |
| 196 | Phosphorylation | MTIDAGCSLHMLRFP EEEECCCEEEEEECC | 22.01 | 26552605 | |
| 206 | Phosphorylation | MLRFPMDSHSCPLSF EEECCCCCCCCCCCC | 15.85 | 25850435 | |
| 208 | Phosphorylation | RFPMDSHSCPLSFSS ECCCCCCCCCCCCCC | 22.75 | 25850435 | |
| 212 | Phosphorylation | DSHSCPLSFSSFSYP CCCCCCCCCCCCCCC | 14.28 | 25850435 | |
| 214 | Phosphorylation | HSCPLSFSSFSYPEN CCCCCCCCCCCCCCC | 27.39 | 25850435 | |
| 215 | Phosphorylation | SCPLSFSSFSYPENE CCCCCCCCCCCCCCC | 19.05 | 25850435 | |
| 217 | Phosphorylation | PLSFSSFSYPENEMI CCCCCCCCCCCCCEE | 41.55 | 25850435 | |
| 218 | Phosphorylation | LSFSSFSYPENEMIY CCCCCCCCCCCCEEE | 16.74 | 25850435 | |
| 225 | Phosphorylation | YPENEMIYKWENFKL CCCCCEEEEEECEEE | 14.56 | 25850435 | |
| 252 | N-linked_Glycosylation | FDFTGVSNKTEIITT EEECCCCCCEEEEEE | 53.51 | UniProtKB CARBOHYD | |
| 310 | Phosphorylation | TESAPARTSLGITSV CCCCCCCCCCCCEEE | 30.34 | 30576142 | |
| 322 | Phosphorylation | TSVLTMTTLGTFSRK EEEEEECCCCCCCCC | 16.62 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBRE_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBRE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBRE_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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