ENTP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENTP4_HUMAN
• UniProt AC: Q9Y227
• Protein Name: Ectonucleoside triphosphate diphosphohydrolase 4
• Gene Name: ENTPD4
• Organism: Homo sapiens (Human).
• Sequence Length: 616
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Localizes in the Golgi and autophagic vacuoles/lysosomes.
• Protein Description: Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP..
• Protein Sequence: MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIMVISVLAAAVSLLYFSVVIIRNKYGRLTRDKKFQRYLARVTDIEATDTNNPNVNYGIVVDCGSSGSRVFVYCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLNFAAEHVPRAKHKETPLYILCTAGMRILPESQQKAILEDLLTDIPVHFDFLFSDSHAEVISGKQEGVYAWIGINFVLGRFEHIEDDDEAVVEVNIPGSESSEAIVRKRTAGILDMGGVSTQIAYEVPKTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDRIFANTIQKNRLLGKQTGLTPDMPYLDPCLPLDIKDEIQQNGQTIYLRGTGDFDLCRETIQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDYNAAKFTKAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHRGFSFPVNYKSLKTALQVYDKEVQWTLGAILYRTRFLPLRDIQQEAFRASHTHWRGVSFVYNHYLFSGCFLVVLLAILLYLLRLRRIHRRTPRSSSAAALWMEEGLPAQNAPGTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	O-linked_Glycosylation	ISCLFPASWHFSISP EEEEECCCEEEECCC	22.71	29351928
45	Phosphorylation	SVLAAAVSLLYFSVV HHHHHHHHHHHHHHH	14.13	20058876
48	Phosphorylation	AAAVSLLYFSVVIIR HHHHHHHHHHHHHHH	10.09	22817900
57	Acetylation	SVVIIRNKYGRLTRD HHHHHHCCCCCCCCC	38.95	7708581
58	Phosphorylation	VVIIRNKYGRLTRDK HHHHHCCCCCCCCCH	15.84	22817900
62	Phosphorylation	RNKYGRLTRDKKFQR HCCCCCCCCCHHHHH	35.15	-
65	Acetylation	YGRLTRDKKFQRYLA CCCCCCCHHHHHHHH	52.80	7708591
75	O-linked_Glycosylation	QRYLARVTDIEATDT HHHHHHHCCCEEECC	26.21	OGP
80	O-linked_Glycosylation	RVTDIEATDTNNPNV HHCCCEEECCCCCCC	30.48	OGP
175	Phosphorylation	KHKETPLYILCTAGM CCCCCCCEEEECCCC	7.95	-
277	O-linked_Glycosylation	LDMGGVSTQIAYEVP ECCCCEEEEEEEECC	22.91	OGP
340	Ubiquitination	ARQRYEDRIFANTIQ HHHHHHHHHHHHHHH	17.62	27667366
348	Ubiquitination	IFANTIQKNRLLGKQ HHHHHHHHCCCCCCC	39.94	27667366
385	Phosphorylation	QQNGQTIYLRGTGDF HHCCCEEEEECCCCH	8.17	22817900
404	N-linked_Glycosylation	ETIQPFMNKTNETQT HHHHHHHCCCCCCCC	48.67	32767432
407	N-linked_Glycosylation	QPFMNKTNETQTSLN HHHHCCCCCCCCHHC	52.51	32767432
464	Ubiquitination	AKDYCATKWSILRER HHHHHHCHHHHHHHH	22.03	-
466	Phosphorylation	DYCATKWSILRERFD HHHHCHHHHHHHHHH	17.19	24719451
503	Ubiquitination	MFEVFHRGFSFPVNY HHHHHHCCCCCCCCH	17.61	27667366
511	Ubiquitination	FSFPVNYKSLKTALQ CCCCCCHHHHHHHHH	44.07	27667366
595	Phosphorylation	IHRRTPRSSSAAALW HHHHCCCCCCHHHHH	29.83	30108239
596	Phosphorylation	HRRTPRSSSAAALWM HHHCCCCCCHHHHHH	25.85	30108239
597	Phosphorylation	RRTPRSSSAAALWME HHCCCCCCHHHHHHH	24.15	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENTP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENTP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENTP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS27_HUMAN	RPS27	physical	21988832
PCYOX_HUMAN	PCYOX1	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
TYW1B_HUMAN	TYW1B	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-385, AND MASSSPECTROMETRY.
PubMed: 15592455