| UniProt ID | NUP98_MOUSE | |
|---|---|---|
| UniProt AC | Q6PFD9 | |
| Protein Name | Nuclear pore complex protein Nup98-Nup96 | |
| Gene Name | Nup98 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1816 | |
| Subcellular Localization |
Nucleus membrane Peripheral membrane protein Nucleoplasmic side . Nucleus, nuclear pore complex . Nucleus, nucleoplasm . Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket. Dissociates from |
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| Protein Description | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body).. | |
| Protein Sequence | MFNKSFGTPFGGSTGGFGTTSTFGQNTGFGTTSGGAFGTSAFGSSNNTGGLFGNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTSNSLFGTASTGTSLFSSQNNAFAQNKPTGFGNFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTAAPTGTTIKFNPPTGTDTMVKAGVSTNISTKHQCITAMKEYESKSLEELRLEDYQANRKGPQNQVGGGTTAGLFGSSPATSSATGLFSSSTTNSAFSYGQNKTAFGTSTTGFGTNPGGLFGQQNQQTTSLFSKPFGQATTTPNTGFSFGNTSTLGQPSTNTMGLFGVTQASQPGGLFGTATNTSTGTAFGTGTGLFGQPNTGFGAVGSTLFGNNKLTTFGTSTTSAPSFGTTSGGLFGNKPTLTLGTNTNTSNFGFGTNNSGSSIFGSKPAAGTLGTGLGTGFGTALGAGQASLFGNNQPKIGGPLGTGAFGAPGFNTSTAILGFGAPQAPVALTDPNASAAQQAVLQQHLNSLTYSPFGDSPLFRNPMSDPKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVNHDSEDLASPSEYPENGERFSFLSKPVDENNQQDGEDDSLVSRFYTNPIAKPIPQTPESVGNKNNSSSNVEDTIVALNMRAALRNGLEGSSEETSFHDESLQDDREEIENNAYHIHPAGIVLTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIRRKEVIVYVDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGLQDSDEEEEEHPPKTTSKKLKTAPLPPAGQATTFQMTLNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVPDSVLEESVPEDQEPVSASTHIASSLGINPHVLQIMKASLLVDEEDVDAMDQRFGHIPSKGETVQEICSPRLPISASHSSKSRSIVGGLLQSKFASGTFLSPSASVQECRTPRTSSRMNIPSTSPWSVPLPLATVFTVPSPAPEVQLKTVGIRRQPGLVPLEKSITYGKGKLLMDMALFMGRSFRVGWGPNWTLANSGEQLHGSHELENHQVADSMEYGFLPNPVAVKSLSESPFKVHLEKLGLRQRKLDEDLQLYQTPLELKLKHSTVHVDELCPLIVPNPGVSVIHDYADWVKDSPGDFLELPIVKHWSLTWTLCEALWGHLKELDGQLDEPSEYIQTLERRRAFSRWLSHTAAPQIEEEVSLTRRDSPVEAVFSYLTGSRISGACCLAQQSGDHRLALLLSQLVGSQSVRELLTMQLADWHQLQADSFIHDERLRIFALLAGKPVWQLSEQKQINVCSQLDWKRTLAIHLWYLLPPTASISRALSMYEEAFQNTPEGDKYACSPLPSYLEGCGCMVEEEKDSRRPLQDVCFHLLKLYSDRHYELNQLLEPRSITADPLDYRLSWHLWEVLRALNYTHLSEQCEGVLQASYAGQLESEGLWEWAIFVFLHIDNSGMREKAVRELLTRHCQLSETPESWAKEAFLTQKLCVPAEWIHEAKAVRAHMESNKHLEALYLFKAGHWNRCHKLVIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLDYIRVIEMLHRIQQVDCSGYELEHLHTKVTSLCNRIEQIPCYNAKDRLAQSDMAKRVANLLRVVLSLQHAPDATSNSTPDPQRVPLRLLAPHIGRLPMPEDYALEELRGLTQSYLRELTVGSQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 193 | Acetylation | HQCITAMKEYESKSL HHHHHHHHHHHCCCH | 22826441 | ||
| 431 | Phosphorylation | PAAGTLGTGLGTGFG CCCCCCCCCCCCCHH | 30352176 | ||
| 524 | Phosphorylation | PLFRNPMSDPKKKEE CCCCCCCCCHHHHHH | 21183079 | ||
| 536 | Phosphorylation | KEERLKPTNPAAQKA HHHHCCCCCHHHHHH | - | ||
| 545 | Phosphorylation | PAAQKALTTPTHYKL HHHHHHCCCCCCCCC | 25159016 | ||
| 546 | Phosphorylation | AAQKALTTPTHYKLT HHHHHCCCCCCCCCC | 22942356 | ||
| 548 | Phosphorylation | QKALTTPTHYKLTPR HHHCCCCCCCCCCCC | 25159016 | ||
| 550 | Phosphorylation | ALTTPTHYKLTPRPA HCCCCCCCCCCCCCC | 25168779 | ||
| 553 | Phosphorylation | TPTHYKLTPRPATRV CCCCCCCCCCCCCCC | 25266776 | ||
| 558 | Phosphorylation | KLTPRPATRVRPKAL CCCCCCCCCCCCCHH | - | ||
| 603 | Acetylation | SIKKLVLKNLNNSNL HHHHHHHHCCCCCCC | - | ||
| 608 | Phosphorylation | VLKNLNNSNLFSPVN HHHCCCCCCCCCCCC | 22942356 | ||
| 612 | Phosphorylation | LNNSNLFSPVNHDSE CCCCCCCCCCCCCCC | 22942356 | ||
| 618 | Phosphorylation | FSPVNHDSEDLASPS CCCCCCCCCCCCCCC | 22802335 | ||
| 623 | Phosphorylation | HDSEDLASPSEYPEN CCCCCCCCCCCCCCC | 26824392 | ||
| 625 | Phosphorylation | SEDLASPSEYPENGE CCCCCCCCCCCCCCC | 22942356 | ||
| 627 | Phosphorylation | DLASPSEYPENGERF CCCCCCCCCCCCCCC | 22802335 | ||
| 635 | Phosphorylation | PENGERFSFLSKPVD CCCCCCCEECCCCCC | 21149613 | ||
| 638 | Phosphorylation | GERFSFLSKPVDENN CCCCEECCCCCCCCC | 21149613 | ||
| 639 | Ubiquitination | ERFSFLSKPVDENNQ CCCEECCCCCCCCCC | - | ||
| 653 | Phosphorylation | QQDGEDDSLVSRFYT CCCCCCCHHHHHHHC | 25521595 | ||
| 656 | Phosphorylation | GEDDSLVSRFYTNPI CCCCHHHHHHHCCCC | 21149613 | ||
| 659 | Phosphorylation | DSLVSRFYTNPIAKP CHHHHHHHCCCCCCC | 19854140 | ||
| 660 | Phosphorylation | SLVSRFYTNPIAKPI HHHHHHHCCCCCCCC | 25159016 | ||
| 665 | Ubiquitination | FYTNPIAKPIPQTPE HHCCCCCCCCCCCCC | - | ||
| 670 | Phosphorylation | IAKPIPQTPESVGNK CCCCCCCCCCHHCCC | 25521595 | ||
| 673 | Phosphorylation | PIPQTPESVGNKNNS CCCCCCCHHCCCCCC | 26824392 | ||
| 680 | Phosphorylation | SVGNKNNSSSNVEDT HHCCCCCCCCCHHHH | 22942356 | ||
| 681 | Phosphorylation | VGNKNNSSSNVEDTI HCCCCCCCCCHHHHH | 25159016 | ||
| 682 | Phosphorylation | GNKNNSSSNVEDTIV CCCCCCCCCHHHHHH | 25159016 | ||
| 687 | Phosphorylation | SSSNVEDTIVALNMR CCCCHHHHHHHHHHH | 25159016 | ||
| 704 | Phosphorylation | LRNGLEGSSEETSFH HHCCCCCCCCCCCCC | 26370283 | ||
| 708 | Phosphorylation | LEGSSEETSFHDESL CCCCCCCCCCCCHHH | 25338131 | ||
| 709 | Phosphorylation | EGSSEETSFHDESLQ CCCCCCCCCCCHHHH | 25338131 | ||
| 714 | Phosphorylation | ETSFHDESLQDDREE CCCCCCHHHHCCHHH | 25338131 | ||
| 746 | Phosphorylation | VGYYTIPSMDDLAKI EEEEECCCHHHHHHH | 26643407 | ||
| 757 | Ubiquitination | LAKITNEKGECIVSD HHHHHCCCCCEEEEE | - | ||
| 802 | Phosphorylation | RRKEVIVYVDDNQKP ECCCEEEEECCCCCC | 27180971 | ||
| 818 | Ubiquitination | VGEGLNRKAEVTLDG CCCCCCCCEEEEECC | - | ||
| 839 | Phosphorylation | TSRCLIKSPDRLADI CCCEEECCCCCCCCC | 26824392 | ||
| 856 | Phosphorylation | EGRLEAVSRKQGAQF CCHHHHHHHHCCCCC | - | ||
| 883 | Phosphorylation | KVSHFSKYGLQDSDE EEEHHHCCCCCCCCH | 28833060 | ||
| 888 | Phosphorylation | SKYGLQDSDEEEEEH HCCCCCCCCHHHHCC | 27087446 | ||
| 916 | Phosphorylation | LPPAGQATTFQMTLN CCCCCCEEEEEEEEC | 28285833 | ||
| 921 | Phosphorylation | QATTFQMTLNGKPAP CEEEEEEEECCEECC | 26643407 | ||
| 932 | Phosphorylation | KPAPPPQSQSPEVEQ EECCCCCCCCCCHHH | 21149613 | ||
| 934 | Phosphorylation | APPPQSQSPEVEQLG CCCCCCCCCCHHHHH | 26824392 | ||
| 997 | Phosphorylation | VLQIMKASLLVDEED HHHHHHHHHCCCHHH | 21149613 | ||
| 1018 | Ubiquitination | RFGHIPSKGETVQEI HCCCCCCCCCCHHHH | - | ||
| 1027 | Phosphorylation | ETVQEICSPRLPISA CCHHHHHCCCCCCCC | 26824392 | ||
| 1033 | O-linked_Glycosylation | CSPRLPISASHSSKS HCCCCCCCCCCCCCC | 25335653 | ||
| 1033 | Phosphorylation | CSPRLPISASHSSKS HCCCCCCCCCCCCCC | 25159016 | ||
| 1035 | Phosphorylation | PRLPISASHSSKSRS CCCCCCCCCCCCCCH | 25159016 | ||
| 1037 | Phosphorylation | LPISASHSSKSRSIV CCCCCCCCCCCCHHH | 25159016 | ||
| 1038 | Phosphorylation | PISASHSSKSRSIVG CCCCCCCCCCCHHHH | 25159016 | ||
| 1040 | Phosphorylation | SASHSSKSRSIVGGL CCCCCCCCCHHHHHH | 28833060 | ||
| 1042 | Phosphorylation | SHSSKSRSIVGGLLQ CCCCCCCHHHHHHHH | 22942356 | ||
| 1050 | Phosphorylation | IVGGLLQSKFASGTF HHHHHHHHHCCCCCE | 28833060 | ||
| 1054 | Phosphorylation | LLQSKFASGTFLSPS HHHHHCCCCCEECCC | 25159016 | ||
| 1056 | Phosphorylation | QSKFASGTFLSPSAS HHHCCCCCEECCCCC | 25159016 | ||
| 1059 | Phosphorylation | FASGTFLSPSASVQE CCCCCEECCCCCHHH | 26824392 | ||
| 1061 | Phosphorylation | SGTFLSPSASVQECR CCCEECCCCCHHHCC | 25159016 | ||
| 1063 | Phosphorylation | TFLSPSASVQECRTP CEECCCCCHHHCCCC | 25159016 | ||
| 1069 | Phosphorylation | ASVQECRTPRTSSRM CCHHHCCCCCCCCCC | 24453211 | ||
| 1080 | Phosphorylation | SSRMNIPSTSPWSVP CCCCCCCCCCCCCCC | 25777480 | ||
| 1081 | Phosphorylation | SRMNIPSTSPWSVPL CCCCCCCCCCCCCCC | 25777480 | ||
| 1082 | Phosphorylation | RMNIPSTSPWSVPLP CCCCCCCCCCCCCCC | 25159016 | ||
| 1085 | Phosphorylation | IPSTSPWSVPLPLAT CCCCCCCCCCCCEEE | 27600695 | ||
| 1092 | Phosphorylation | SVPLPLATVFTVPSP CCCCCEEEEEECCCC | 25777480 | ||
| 1095 | Phosphorylation | LPLATVFTVPSPAPE CCEEEEEECCCCCCC | 25777480 | ||
| 1098 | Phosphorylation | ATVFTVPSPAPEVQL EEEEECCCCCCCCEE | 27180971 | ||
| 1189 | Phosphorylation | PVAVKSLSESPFKVH CEEECCCCCCCCHHH | 27841257 | ||
| 1199 | Ubiquitination | PFKVHLEKLGLRQRK CCHHHHHHHCCCCCC | - | ||
| 1206 | Ubiquitination | KLGLRQRKLDEDLQL HHCCCCCCCCCCHHH | - | ||
| 1328 | Phosphorylation | VSLTRRDSPVEAVFS HHCCCCCCCHHHHHH | 27180971 | ||
| 1335 | Phosphorylation | SPVEAVFSYLTGSRI CCHHHHHHHHHCCCC | 23567750 | ||
| 1464 | Phosphorylation | EGDKYACSPLPSYLE CCCCCCCCCCCHHHC | 25521595 | ||
| 1711 | Phosphorylation | RIQQVDCSGYELEHL HHHCCCCCCCCHHHH | 29514104 | ||
| 1767 | Phosphorylation | LQHAPDATSNSTPDP HHCCCCCCCCCCCCC | 25159016 | ||
| 1768 | Phosphorylation | QHAPDATSNSTPDPQ HCCCCCCCCCCCCCC | 25159016 | ||
| 1770 | Phosphorylation | APDATSNSTPDPQRV CCCCCCCCCCCCCCC | 25159016 | ||
| 1771 | Phosphorylation | PDATSNSTPDPQRVP CCCCCCCCCCCCCCC | 26824392 | ||
| 1815 | Phosphorylation | LRELTVGSQ------ HHHHCCCCC------ | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUP98_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUP98_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUP98_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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