NK1R_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NK1R_HUMAN
• UniProt AC: P25103
• Protein Name: Substance-P receptor
• Gene Name: TACR1
• Organism: Homo sapiens (Human).
• Sequence Length: 407
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K..
• Protein Sequence: MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	N-linked_Glycosylation	VDSDLSPNISTNTSE CCCCCCCCCCCCCCC	37.15	UniProtKB CARBOHYD
18	N-linked_Glycosylation	LSPNISTNTSEPNQF CCCCCCCCCCCCCCC	34.51	UniProtKB CARBOHYD
322	S-palmitoylation	GFKHAFRCCPFISAG CCCCHHHHCCCCCCC	2.53	-
341	Phosphorylation	LEMKSTRYLQTQGSV CCCCCEEEEECCCCE	11.84	24719451
347	Phosphorylation	RYLQTQGSVYKVSRL EEEECCCCEEEEEEE	16.68	28857561
407	Phosphorylation	SFSSNVLS------- ECCCCCCC-------	33.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NK1R_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NK1R_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NK1R_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RDH14_HUMAN	RDH14	physical	28514442
CAV1_HUMAN	CAV1	physical	28514442
FADS1_HUMAN	FADS1	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
PKP2_HUMAN	PKP2	physical	28514442
ARVC_HUMAN	ARVCF	physical	28514442
COX1_HUMAN	COX1	physical	28514442
PRAF3_HUMAN	ARL6IP5	physical	28514442
ATP8_HUMAN	ATP8	physical	28514442
MFSD5_HUMAN	MFSD5	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
PKP4_HUMAN	PKP4	physical	28514442
STX4_HUMAN	STX4	physical	28514442
PAQR1_HUMAN	ADIPOR1	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
S2546_HUMAN	SLC25A46	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
AT5F1_HUMAN	ATP5F1	physical	28514442
TM164_HUMAN	TMEM164	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
RGPD2_HUMAN	RGPD2	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
LMBD2_HUMAN	LMBRD2	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
ATP5H_HUMAN	ATP5H	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.