UniProt ID | CARD8_HUMAN | |
---|---|---|
UniProt AC | Q9Y2G2 | |
Protein Name | Caspase recruitment domain-containing protein 8 | |
Gene Name | CARD8 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 431 | |
Subcellular Localization | Cytoplasm . Nucleus . | |
Protein Description | Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.. | |
Protein Sequence | MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
22 | Phosphorylation | LSVNYLGGTFPGDIC EEEECCCCCCCCCCC | 22.91 | 24719451 | |
22 (in isoform 5) | Phosphorylation | - | 22.91 | 24719451 | |
22 (in isoform 3) | Phosphorylation | - | 22.91 | 24719451 | |
25 (in isoform 5) | Phosphorylation | - | 39.11 | 24247654 | |
25 (in isoform 3) | Phosphorylation | - | 39.11 | 24247654 | |
29 (in isoform 4) | Phosphorylation | - | 5.08 | 27251275 | |
31 (in isoform 4) | Phosphorylation | - | 57.46 | 27251275 | |
36 (in isoform 4) | Phosphorylation | - | 1.93 | 27251275 | |
52 | Ubiquitination | FEIEEDYKNRQFLGP EEEEHHHCCCCCCCC | 58.96 | - | |
70 | Ubiquitination | VDVELIDKSTNRYSV EEEEEEECCCCEEEE | 52.78 | - | |
79 | Phosphorylation | TNRYSVWFPTAGWYL CCEEEEEEECHHHHH | 3.45 | 27251275 | |
79 (in isoform 5) | Phosphorylation | - | 3.45 | 27251275 | |
79 (in isoform 3) | Phosphorylation | - | 3.45 | 27251275 | |
81 (in isoform 3) | Phosphorylation | - | 28.47 | 27251275 | |
81 (in isoform 5) | Phosphorylation | - | 28.47 | 27251275 | |
86 (in isoform 3) | Phosphorylation | - | 2.04 | 27251275 | |
86 (in isoform 5) | Phosphorylation | - | 2.04 | 27251275 | |
229 | Phosphorylation | EDIKFHLYLVPSDAL HHCCEEEEEECCCHH | 9.33 | 24719451 | |
233 | Phosphorylation | FHLYLVPSDALLTKA EEEEEECCCHHCHHC | 28.21 | 27251275 | |
238 | Phosphorylation | VPSDALLTKAIDDEE ECCCHHCHHCCCCCC | 21.19 | 24719451 | |
267 | Phosphorylation | EPLNFGSSYIVSNSA CCCCCCCEEEEECCC | 21.18 | 27067055 | |
268 | Phosphorylation | PLNFGSSYIVSNSAN CCCCCCEEEEECCCC | 13.67 | 27067055 | |
271 | Phosphorylation | FGSSYIVSNSANLKV CCCEEEEECCCCCEE | 18.60 | 27067055 | |
273 | Phosphorylation | SSYIVSNSANLKVMP CEEEEECCCCCEECC | 15.84 | 27067055 | |
286 | Phosphorylation | MPKELKLSYRSPGEI CCCEEEECCCCHHHH | 19.53 | 28450419 | |
287 | Phosphorylation | PKELKLSYRSPGEIQ CCEEEECCCCHHHHH | 26.08 | 28450419 | |
289 | Phosphorylation | ELKLSYRSPGEIQHF EEEECCCCHHHHHHH | 29.08 | 28450419 | |
335 | Phosphorylation | PVDLQLVAASAPPPF CCCEEEEECCCCCCC | 12.32 | 24719451 | |
339 | Phosphorylation | QLVAASAPPPFSGAA EEEECCCCCCCCCCC | 34.30 | 27251275 | |
344 | Phosphorylation | SAPPPFSGAAFVKEN CCCCCCCCCCHHHHH | 22.70 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CARD8_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CARD8_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CARD8_HUMAN !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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