CARD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARD8_HUMAN
• UniProt AC: Q9Y2G2
• Protein Name: Caspase recruitment domain-containing protein 8
• Gene Name: CARD8
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases..
• Protein Sequence: MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LSVNYLGGTFPGDIC EEEECCCCCCCCCCC	22.91	24719451
22 (in isoform 5)	Phosphorylation	-	22.91	24719451
22 (in isoform 3)	Phosphorylation	-	22.91	24719451
25 (in isoform 5)	Phosphorylation	-	39.11	24247654
25 (in isoform 3)	Phosphorylation	-	39.11	24247654
29 (in isoform 4)	Phosphorylation	-	5.08	27251275
31 (in isoform 4)	Phosphorylation	-	57.46	27251275
36 (in isoform 4)	Phosphorylation	-	1.93	27251275
52	Ubiquitination	FEIEEDYKNRQFLGP EEEEHHHCCCCCCCC	58.96	-
70	Ubiquitination	VDVELIDKSTNRYSV EEEEEEECCCCEEEE	52.78	-
79	Phosphorylation	TNRYSVWFPTAGWYL CCEEEEEEECHHHHH	3.45	27251275
79 (in isoform 5)	Phosphorylation	-	3.45	27251275
79 (in isoform 3)	Phosphorylation	-	3.45	27251275
81 (in isoform 3)	Phosphorylation	-	28.47	27251275
81 (in isoform 5)	Phosphorylation	-	28.47	27251275
86 (in isoform 3)	Phosphorylation	-	2.04	27251275
86 (in isoform 5)	Phosphorylation	-	2.04	27251275
229	Phosphorylation	EDIKFHLYLVPSDAL HHCCEEEEEECCCHH	9.33	24719451
233	Phosphorylation	FHLYLVPSDALLTKA EEEEEECCCHHCHHC	28.21	27251275
238	Phosphorylation	VPSDALLTKAIDDEE ECCCHHCHHCCCCCC	21.19	24719451
267	Phosphorylation	EPLNFGSSYIVSNSA CCCCCCCEEEEECCC	21.18	27067055
268	Phosphorylation	PLNFGSSYIVSNSAN CCCCCCEEEEECCCC	13.67	27067055
271	Phosphorylation	FGSSYIVSNSANLKV CCCEEEEECCCCCEE	18.60	27067055
273	Phosphorylation	SSYIVSNSANLKVMP CEEEEECCCCCEECC	15.84	27067055
286	Phosphorylation	MPKELKLSYRSPGEI CCCEEEECCCCHHHH	19.53	28450419
287	Phosphorylation	PKELKLSYRSPGEIQ CCEEEECCCCHHHHH	26.08	28450419
289	Phosphorylation	ELKLSYRSPGEIQHF EEEECCCCHHHHHHH	29.08	28450419
335	Phosphorylation	PVDLQLVAASAPPPF CCCEEEEECCCCCCC	12.32	24719451
339	Phosphorylation	QLVAASAPPPFSGAA EEEECCCCCCCCCCC	34.30	27251275
344	Phosphorylation	SAPPPFSGAAFVKEN CCCCCCCCCCHHHHH	22.70	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEMO_HUMAN	IKBKG	physical	11551959
FLNA_HUMAN	FLNA	physical	26186194
FLNC_HUMAN	FLNC	physical	26186194
CSR2B_HUMAN	CSRP2BP	physical	26186194
DMAP1_HUMAN	DMAP1	physical	26186194
BRCA2_HUMAN	BRCA2	physical	26186194
YETS2_HUMAN	YEATS2	physical	26186194
TAB1_HUMAN	TAB1	physical	26186194
BCOR_HUMAN	BCOR	physical	26186194
NFRKB_HUMAN	NFRKB	physical	26186194
SRCAP_HUMAN	SRCAP	physical	26186194
ZZZ3_HUMAN	ZZZ3	physical	26186194
ZN318_HUMAN	ZNF318	physical	26186194
LRIF1_HUMAN	LRIF1	physical	26186194
MGAP_HUMAN	MGA	physical	26186194
MBIP1_HUMAN	MBIP	physical	26186194
SETX_HUMAN	SETX	physical	26186194
BCD1_HUMAN	ZNHIT6	physical	26186194
ATX2_HUMAN	ATXN2	physical	26186194
SALL2_HUMAN	SALL2	physical	26186194
ARP6_HUMAN	ACTR6	physical	26186194
TAD2A_HUMAN	TADA2A	physical	26186194
PEAK1_HUMAN	PEAK1	physical	26186194
VPS72_HUMAN	VPS72	physical	26186194
CHD8_HUMAN	CHD8	physical	26186194
WDR74_HUMAN	WDR74	physical	26186194
HDAC3_HUMAN	HDAC3	physical	26186194
E2F6_HUMAN	E2F6	physical	26186194
TAB2_HUMAN	TAB2	physical	26186194
DPH1_HUMAN	DPH1	physical	26186194
HXA5_HUMAN	HOXA5	physical	26186194
M3K7_HUMAN	MAP3K7	physical	26186194
HXD13_HUMAN	HOXD13	physical	26186194
NPRL3_HUMAN	NPRL3	physical	26186194
CO039_HUMAN	C15orf39	physical	26186194
UBP54_HUMAN	USP54	physical	26186194
LRIF1_HUMAN	LRIF1	physical	28514442
CSR2B_HUMAN	CSRP2BP	physical	28514442
MBIP1_HUMAN	MBIP	physical	28514442
ZZZ3_HUMAN	ZZZ3	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
WDR74_HUMAN	WDR74	physical	28514442
CHD8_HUMAN	CHD8	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
TAD2A_HUMAN	TADA2A	physical	28514442
E2F6_HUMAN	E2F6	physical	28514442
M3K7_HUMAN	MAP3K7	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442
ATX2_HUMAN	ATXN2	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
PCGF6_HUMAN	PCGF6	physical	28514442
HDAC3_HUMAN	HDAC3	physical	28514442
VPS72_HUMAN	VPS72	physical	28514442
FLNA_HUMAN	FLNA	physical	28514442
TAB2_HUMAN	TAB2	physical	28514442
PEAK1_HUMAN	PEAK1	physical	28514442
SGF29_HUMAN	CCDC101	physical	28514442
SRCAP_HUMAN	SRCAP	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
ARP6_HUMAN	ACTR6	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
SALL2_HUMAN	SALL2	physical	28514442
LRCH2_HUMAN	LRCH2	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
TADA3_HUMAN	TADA3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.