CARD8_HUMAN - dbPTM
CARD8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CARD8_HUMAN
UniProt AC Q9Y2G2
Protein Name Caspase recruitment domain-containing protein 8
Gene Name CARD8
Organism Homo sapiens (Human).
Sequence Length 431
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases..
Protein Sequence MMRQRQSHYCSVLFLSVNYLGGTFPGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationLSVNYLGGTFPGDIC
EEEECCCCCCCCCCC
22.9124719451
22 (in isoform 5)Phosphorylation-22.9124719451
22 (in isoform 3)Phosphorylation-22.9124719451
25 (in isoform 5)Phosphorylation-39.1124247654
25 (in isoform 3)Phosphorylation-39.1124247654
29 (in isoform 4)Phosphorylation-5.0827251275
31 (in isoform 4)Phosphorylation-57.4627251275
36 (in isoform 4)Phosphorylation-1.9327251275
52UbiquitinationFEIEEDYKNRQFLGP
EEEEHHHCCCCCCCC
58.96-
70UbiquitinationVDVELIDKSTNRYSV
EEEEEEECCCCEEEE
52.78-
79PhosphorylationTNRYSVWFPTAGWYL
CCEEEEEEECHHHHH
3.4527251275
79 (in isoform 5)Phosphorylation-3.4527251275
79 (in isoform 3)Phosphorylation-3.4527251275
81 (in isoform 3)Phosphorylation-28.4727251275
81 (in isoform 5)Phosphorylation-28.4727251275
86 (in isoform 3)Phosphorylation-2.0427251275
86 (in isoform 5)Phosphorylation-2.0427251275
229PhosphorylationEDIKFHLYLVPSDAL
HHCCEEEEEECCCHH
9.3324719451
233PhosphorylationFHLYLVPSDALLTKA
EEEEEECCCHHCHHC
28.2127251275
238PhosphorylationVPSDALLTKAIDDEE
ECCCHHCHHCCCCCC
21.1924719451
267PhosphorylationEPLNFGSSYIVSNSA
CCCCCCCEEEEECCC
21.1827067055
268PhosphorylationPLNFGSSYIVSNSAN
CCCCCCEEEEECCCC
13.6727067055
271PhosphorylationFGSSYIVSNSANLKV
CCCEEEEECCCCCEE
18.6027067055
273PhosphorylationSSYIVSNSANLKVMP
CEEEEECCCCCEECC
15.8427067055
286PhosphorylationMPKELKLSYRSPGEI
CCCEEEECCCCHHHH
19.5328450419
287PhosphorylationPKELKLSYRSPGEIQ
CCEEEECCCCHHHHH
26.0828450419
289PhosphorylationELKLSYRSPGEIQHF
EEEECCCCHHHHHHH
29.0828450419
335PhosphorylationPVDLQLVAASAPPPF
CCCEEEEECCCCCCC
12.3224719451
339PhosphorylationQLVAASAPPPFSGAA
EEEECCCCCCCCCCC
34.3027251275
344PhosphorylationSAPPPFSGAAFVKEN
CCCCCCCCCCHHHHH
22.7024719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CARD8_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CARD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CARD8_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEMO_HUMANIKBKGphysical
11551959
FLNA_HUMANFLNAphysical
26186194
FLNC_HUMANFLNCphysical
26186194
CSR2B_HUMANCSRP2BPphysical
26186194
DMAP1_HUMANDMAP1physical
26186194
BRCA2_HUMANBRCA2physical
26186194
YETS2_HUMANYEATS2physical
26186194
TAB1_HUMANTAB1physical
26186194
BCOR_HUMANBCORphysical
26186194
NFRKB_HUMANNFRKBphysical
26186194
SRCAP_HUMANSRCAPphysical
26186194
ZZZ3_HUMANZZZ3physical
26186194
ZN318_HUMANZNF318physical
26186194
LRIF1_HUMANLRIF1physical
26186194
MGAP_HUMANMGAphysical
26186194
MBIP1_HUMANMBIPphysical
26186194
SETX_HUMANSETXphysical
26186194
BCD1_HUMANZNHIT6physical
26186194
ATX2_HUMANATXN2physical
26186194
SALL2_HUMANSALL2physical
26186194
ARP6_HUMANACTR6physical
26186194
TAD2A_HUMANTADA2Aphysical
26186194
PEAK1_HUMANPEAK1physical
26186194
VPS72_HUMANVPS72physical
26186194
CHD8_HUMANCHD8physical
26186194
WDR74_HUMANWDR74physical
26186194
HDAC3_HUMANHDAC3physical
26186194
E2F6_HUMANE2F6physical
26186194
TAB2_HUMANTAB2physical
26186194
DPH1_HUMANDPH1physical
26186194
HXA5_HUMANHOXA5physical
26186194
M3K7_HUMANMAP3K7physical
26186194
HXD13_HUMANHOXD13physical
26186194
NPRL3_HUMANNPRL3physical
26186194
CO039_HUMANC15orf39physical
26186194
UBP54_HUMANUSP54physical
26186194
LRIF1_HUMANLRIF1physical
28514442
CSR2B_HUMANCSRP2BPphysical
28514442
MBIP1_HUMANMBIPphysical
28514442
ZZZ3_HUMANZZZ3physical
28514442
YETS2_HUMANYEATS2physical
28514442
WDR74_HUMANWDR74physical
28514442
CHD8_HUMANCHD8physical
28514442
MGAP_HUMANMGAphysical
28514442
TAD2A_HUMANTADA2Aphysical
28514442
E2F6_HUMANE2F6physical
28514442
M3K7_HUMANMAP3K7physical
28514442
CO039_HUMANC15orf39physical
28514442
NFRKB_HUMANNFRKBphysical
28514442
ATX2_HUMANATXN2physical
28514442
BCD1_HUMANZNHIT6physical
28514442
PCGF6_HUMANPCGF6physical
28514442
HDAC3_HUMANHDAC3physical
28514442
VPS72_HUMANVPS72physical
28514442
FLNA_HUMANFLNAphysical
28514442
TAB2_HUMANTAB2physical
28514442
PEAK1_HUMANPEAK1physical
28514442
SGF29_HUMANCCDC101physical
28514442
SRCAP_HUMANSRCAPphysical
28514442
DPH1_HUMANDPH1physical
28514442
UBP54_HUMANUSP54physical
28514442
ARP6_HUMANACTR6physical
28514442
BCOR_HUMANBCORphysical
28514442
SALL2_HUMANSALL2physical
28514442
LRCH2_HUMANLRCH2physical
28514442
TAB1_HUMANTAB1physical
28514442
TADA3_HUMANTADA3physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CARD8_HUMAN

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Related Literatures of Post-Translational Modification

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