dbPTM

ASGR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASGR2_HUMAN
UniProt AC	P07307
Protein Name	Asialoglycoprotein receptor 2
Gene Name	ASGR2
Organism	Homo sapiens (Human).
Sequence Length	311
Subcellular Localization	Membrane Single-pass type II membrane protein.
Protein Description	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface..
Protein Sequence	MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	FQDIQQLSSEENDHP HHHHHHHCCCCCCCC	31.22	1924301
13	Phosphorylation	QDIQQLSSEENDHPF HHHHHHCCCCCCCCC	58.48	26422651
54	S-palmitoylation	QPLAQRLCSMVCFSL HHHHHHHHHHHHHHH	2.41	-
102	N-linked_Glycosylation	SLKEAFSNFSSSTLT HHHHHHHCCCCCCCE	34.07	16335952
134	Acetylation	SLGAKLEKQQQDLKA HHHHHHHHHHHHHHC	64.94	23749302
170	N-linked_Glycosylation	QMELLHSNGSQRTCC HHHHHHCCCCCCEEE	43.30	19159218
305	N-linked_Glycosylation	WVCEKRRNATGEVA- HHHHHHHCCCCCCC-	45.98	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
12	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASGR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASGR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CERS2_HUMAN	CERS2	physical	11543633
EDEM1_HUMAN	EDEM1	physical	21062743
ERLEC_HUMAN	ERLEC1	physical	21062743
SYVN1_HUMAN	SYVN1	physical	21062743
FBX6_HUMAN	FBXO6	physical	21062743
DERL1_HUMAN	DERL1	physical	21062743
ERLEC_HUMAN	ERLEC1	physical	21917589
OS9_HUMAN	OS9	physical	21917589
CERS2_HUMAN	CERS2	physical	21988832
DHE3_HUMAN	GLUD1	physical	21988832
HES1_HUMAN	HES1	physical	21988832
MROH5_HUMAN	MROH5	physical	21988832
TM214_HUMAN	TMEM214	physical	26186194
S38A9_HUMAN	SLC38A9	physical	26186194
TTYH3_HUMAN	TTYH3	physical	26186194
P121A_HUMAN	POM121	physical	26186194
FKRP_HUMAN	FKRP	physical	26186194
SENP5_HUMAN	SENP5	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
RL23_HUMAN	RPL23	physical	26186194
PARVG_HUMAN	PARVG	physical	26186194
SOAT1_HUMAN	SOAT1	physical	26186194
TIMP3_HUMAN	TIMP3	physical	26186194
SERC1_HUMAN	SERINC1	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
LMA2L_HUMAN	LMAN2L	physical	26186194
TMPPE_HUMAN	TMPPE	physical	26186194
GOGA5_HUMAN	GOLGA5	physical	26186194
SBP1_HUMAN	SELENBP1	physical	26186194
PTN1_HUMAN	PTPN1	physical	26186194
LMBR1_HUMAN	LMBR1	physical	26186194
AGRL3_HUMAN	LPHN3	physical	26186194
MANEA_HUMAN	MANEA	physical	26186194
JMJD8_HUMAN	JMJD8	physical	26186194
COX1_HUMAN	COX1	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
AG10A_HUMAN	ALG10	physical	26186194
MFSD8_HUMAN	MFSD8	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
HACD2_HUMAN	PTPLB	physical	26186194
ZDH18_HUMAN	ZDHHC18	physical	26186194
TM214_HUMAN	TMEM214	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
PARVG_HUMAN	PARVG	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
S38A9_HUMAN	SLC38A9	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
JMJD8_HUMAN	JMJD8	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
FKRP_HUMAN	FKRP	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
AGRL3_HUMAN	LPHN3	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
COX1_HUMAN	COX1	physical	28514442
LMA2L_HUMAN	LMAN2L	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASGR2_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102 AND ASN-170, AND MASSSPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102, AND MASSSPECTROMETRY.	16335952 [Abstract]