TPL_ARATH - dbPTM
TPL_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPL_ARATH
UniProt AC Q94AI7
Protein Name Protein TOPLESS
Gene Name TPL
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 1131
Subcellular Localization Nucleus .
Protein Description Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes. [PubMed: 23034631 Required for ovule development]
Protein Sequence MSSLSRELVFLILQFLDEEKFKETVHKLEQESGFFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSMKIFFEIRKQKYLEALDKHDRPKAVDILVKDLKVFSTFNEELFKEITQLLTLENFRENEQLSKYGDTKSARAIMLVELKKLIEANPLFRDKLQFPTLRNSRLRTLINQSLNWQHQLCKNPRPNPDIKTLFVDHSCGPPNGARAPSPVNNPLLGGIPKAGGFPPLGAHGPFQPTASPVPTPLAGWMSSPSSVPHPAVSAGAIALGGPSIPAALKHPRTPPTNASLDYPSADSEHVSKRTRPMGISDEVNLGVNMLPMSFSGQAHGHSPAFKAPDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNVGDIGLWEVGSRERLVQKTFKVWDLSKCSMPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQHLEIDAHVGGVNDISFSTPNKQLCVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHYKENIQFIFSTALDGKIKAWLYDNMGSRVDYDAPGRWCTTMAYSADGTRLFSCGTSKDGESFIVEWNESEGAVKRTYQGFHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDAVQLLTAIDGDGGLQASPRIRFNKEGSLLAVSGNENVIKIMANSDGLRLLHTFENISSESSKPAINSIAAAAAAAATSAGHADRSANVVSIQGMNGDSRNMVDVKPVITEESNDKSKIWKLTEVSEPSQCRSLRLPENLRVAKISRLIFTNSGNAILALASNAIHLLWKWQRNERNATGKATASLPPQQWQPASGILMTNDVAETNPEEAVPCFALSKNDSYVMSASGGKISLFNMMTFKTMATFMPPPPAATFLAFHPQDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQRSKVLPLPQGRPNSAPSDTRVQFHQDQAHFLVVHETQLAIYETTKLECMKQWAVRESLAPITHATFSCDSQLVYASFMDATVCVFSSANLRLRCRVNPSAYLPASLSNSNVHPLVIAAHPQEPNMFAVGLSDGGVHIFEPLESEGKWGVAPPAENGSASGAPTAPSVGASASDQPQR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
133PhosphorylationENEQLSKYGDTKSAR
HHHHHHHHCCCHHHH		19.5019880383
214PhosphorylationPNGARAPSPVNNPLL
CCCCCCCCCCCCCCC		40.2630291188
286PhosphorylationAALKHPRTPPTNASL
HHHCCCCCCCCCCCC		37.7630291188
289PhosphorylationKHPRTPPTNASLDYP
CCCCCCCCCCCCCCC		44.6223776212
292PhosphorylationRTPPTNASLDYPSAD
CCCCCCCCCCCCCCC		24.6823776212
295PhosphorylationPTNASLDYPSADSEH
CCCCCCCCCCCCCHH		12.3623776212
297PhosphorylationNASLDYPSADSEHVS
CCCCCCCCCCCHHCC		38.1823776212
300PhosphorylationLDYPSADSEHVSKRT
CCCCCCCCHHCCCCC		29.3523776212
304PhosphorylationSADSEHVSKRTRPMG
CCCCHHCCCCCCCCC		20.5123776212
688PhosphorylationENISSESSKPAINSI
ECCCCCCCHHHHHHH		38.3124601666
704PhosphorylationAAAAAAATSAGHADR
HHHHHHHHHHCCCCC		17.8727288362
705PhosphorylationAAAAAATSAGHADRS
HHHHHHHHHCCCCCC		27.7629654922
736PhosphorylationVDVKPVITEESNDKS
EEEECEEECCCCCCC		33.6519880383
739PhosphorylationKPVITEESNDKSKIW
ECEEECCCCCCCCEE		44.0630291188
1111PhosphorylationAPPAENGSASGAPTA
CCCCCCCCCCCCCCC		30.7323776212
1113PhosphorylationPAENGSASGAPTAPS
CCCCCCCCCCCCCCC		36.8723776212
1117PhosphorylationGSASGAPTAPSVGAS
CCCCCCCCCCCCCCC		51.1423776212
1120PhosphorylationSGAPTAPSVGASASD
CCCCCCCCCCCCCCC		30.6223776212
1124PhosphorylationTAPSVGASASDQPQR
CCCCCCCCCCCCCCC		23.5223776212
1126PhosphorylationPSVGASASDQPQR--
CCCCCCCCCCCCC--		33.9923776212
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPL_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPL_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPL_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IAA12_ARATHIAA12physical
18258861
SUMO1_ARATHSUMO1physical
20813957
LBD41_ARATHLBD41physical
22065421
LBD37_ARATHLBD37physical
22065421
RVE7_ARATHEPR1physical
22065421
RAVL1_ARATHTEM1physical
22065421
HSFB1_ARATHHSF4physical
22065421
ERF82_ARATHERF3physical
22065421
ERF78_ARATHERF4physical
22065421
ERF83_ARATHERF7physical
22065421
ERF76_ARATHERF11physical
22065421
WOX4_ARATHWOX4physical
22065421
ZAT6_ARATHZAT6physical
22065421
WIP3_ARATHWIP3physical
22065421
ZAT10_ARATHSTZphysical
22065421
MYB32_ARATHMYB32physical
22065421
RVE1_ARATHRVE1physical
22065421
TI11A_ARATHJAZ5physical
22065421
TI11B_ARATHJAZ6physical
22065421
IAA2_ARATHIAA2physical
22065421
IAA7_ARATHIAA7physical
22065421
IAA16_ARATHIAA16physical
22065421
ARFB_ARATHARF2physical
22065421
ARFI_ARATHARF9physical
22065421
Y2608_ARATHAT2G36080physical
22065421
SPL1_ARATHSPL1physical
22065421
AFP3_ARATHAFP3physical
22065421
MSI4_ARATHFVEphysical
22065421
EMF1_ARATHEMF1physical
22065421
VIL1_ARATHVRN5physical
22065421
ARI1_ARATHARI1physical
22065421
RAP27_ARATHRAP2.7physical
22065421
IAA10_ARATHIAA10physical
22065421
ARFQ_ARATHARF17physical
22065421
TOE2_ARATHTOE2physical
22065421
IAA1_ARATHIAA1physical
22065421
IAA11_ARATHIAA11physical
22065421
AS1_ARATHAS1physical
22065421
BZIP9_ARATHBZIP9physical
22065421
RAV1_ARATHRAV1physical
22065421
AP2_ARATHAP2physical
22065421
IAA19_ARATHIAA19physical
22065421
HFB2B_ARATHAT-HSFB2Bphysical
22065421
RAVL3_ARATHAT1G51120physical
22065421
TCP4_ARATHTCP4physical
22065421
SOC1_ARATHAGL20physical
22065421
IAA13_ARATHIAA13physical
22065421
AGL15_ARATHAGL15physical
22065421
ZFP4_ARATHZFP4physical
22065421
IAA3_ARATHSHY2physical
22065421
IAA4_ARATHATAUX2-11physical
22065421
GAT16_ARATHGATA16physical
22065421
RAVL2_ARATHAT1G50680physical
22065421
TCP3_ARATHTCP3physical
22065421
HAT1_ARATHHAT1physical
22065421
ERF81_ARATHERF12physical
22065421
TCP2_ARATHTCP2physical
22065421
WOX2_ARATHWOX2physical
22065421
Y2172_ARATHAT2G31720physical
22065421
HAT22_ARATHHAT22physical
22065421
IAA26_ARATHPAP1physical
22065421
IAA28_ARATHIAA28physical
22065421
ERF77_ARATHERF10physical
22065421
SUVH3_ARATHSUVH3physical
22065421
ZFP8_ARATHZFP8physical
22065421
ERF79_ARATHERF8physical
22065421
NGA2_ARATHNGA2physical
22065421
KAN1_ARATHKANphysical
22065421
Y5625_ARATHAT5G06250physical
22065421
NGA1_ARATHNGA1physical
21798944
IAA1_ARATHIAA1physical
21798944
TOE2_ARATHTOE2physical
21798944
TI11A_ARATHJAZ5physical
21798944
IAA8_ARATHIAA8physical
21798944
GRXS3_ARATHAT4G15700physical
21798944
DRIPH_ARATHAT3G23060physical
21798944
TPL_ARATHTPLphysical
21798944
IAA19_ARATHIAA19physical
21798944
MYB4_ARATHMYB4physical
21798944
WOX4_ARATHWOX4physical
21798944
IAA16_ARATHIAA16physical
21798944
IAA27_ARATHPAP2physical
21798944
IAA7_ARATHIAA7physical
21798944
SOC1_ARATHAGL20physical
21798944
IAA2_ARATHIAA2physical
21798944
IAA11_ARATHIAA11physical
21798944
KAN1_ARATHKANphysical
21798944
MYB3_ARATHMYB3physical
21798944
ERF80_ARATHERF9physical
21798944
NIMI2_ARATHNIMIN-2physical
21798944
TIF5A_ARATHJAZ8physical
21798944
AP2_ARATHAP2physical
23034631
HDA19_ARATHHD1physical
23034631
TPL_ARATHTPLphysical
23034631
NINJA_ARATHNINJAphysical
22994806
NINJA_ARATHNINJAphysical
24416306
APRR5_ARATHPRR5physical
23267111
APRR9_ARATHPRR9physical
23267111
APRR7_ARATHPRR7physical
23267111
TPL_ARATHTPLphysical
23267111
BZR1_ARATHBZR1physical
24938363
BZR2_ARATHBES1physical
24938150
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPL_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 AND THR-286, ANDMASS SPECTROMETRY.
"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214, AND MASSSPECTROMETRY.

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