dbPTM

BZR2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BZR2_ARATH
UniProt AC	Q9LN63
Protein Name	Protein BRASSINAZOLE-RESISTANT 2 {ECO:0000303\|PubMed:11970900}
Gene Name	BZR2 {ECO:0000303\|PubMed:11970900}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	335
Subcellular Localization	Nucleus . Cytoplasm . Brassinosteroid treatment triggers nuclear accumulation.
Protein Description	Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N-terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C-terminal domain is probably involved in transcriptional activation. [PubMed: 12007405]
Protein Sequence	MTSDGATSTSAAAAAAAMATRRKPSWRERENNRRRERRRRAVAAKIYTGLRAQGNYNLPKHCDNNEVLKALCSEAGWVVEEDGTTYRKGHKPLPGDMAGSSSRATPYSSHNQSPLSSTFDSPILSYQVSPSSSSFPSPSRVGDPHNISTIFPFLRNGGIPSSLPPLRISNSAPVTPPVSSPTSRNPKPLPTWESFTKQSMSMAAKQSMTSLNYPFYAVSAPASPTHHRQFHAPATIPECDESDSSTVDSGHWISFQKFAQQQPFSASMVPTSPTFNLVKPAPQQLSPNTAAIQEIGQSSEFKFENSQVKPWEGERIHDVAMEDLELTLGNGKAHS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSDGATST ------CCCCCCHHH	35.21	19376835
3	Phosphorylation	-----MTSDGATSTS -----CCCCCCHHHH	32.52	19376835
7	Phosphorylation	-MTSDGATSTSAAAA -CCCCCCHHHHHHHH	37.76	19376835
8	Phosphorylation	MTSDGATSTSAAAAA CCCCCCHHHHHHHHH	21.60	19376835
9	Phosphorylation	TSDGATSTSAAAAAA CCCCCHHHHHHHHHH	20.31	19376835
10	Phosphorylation	SDGATSTSAAAAAAA CCCCHHHHHHHHHHH	18.71	25561503
100	Phosphorylation	LPGDMAGSSSRATPY CCCCCCCCCCCCCCC	18.66	25561503
129	Phosphorylation	PILSYQVSPSSSSFP CEEEEEECCCCCCCC	11.98	29654922
137	Phosphorylation	PSSSSFPSPSRVGDP CCCCCCCCCCCCCCC	33.23	29654922
169	Phosphorylation	SLPPLRISNSAPVTP CCCCCEECCCCCCCC	20.49	30291188
171	Phosphorylation	PPLRISNSAPVTPPV CCCEECCCCCCCCCC	27.45	30291188
175	Phosphorylation	ISNSAPVTPPVSSPT ECCCCCCCCCCCCCC	22.33	23776212
179	Phosphorylation	APVTPPVSSPTSRNP CCCCCCCCCCCCCCC	36.05	23776212
180	Phosphorylation	PVTPPVSSPTSRNPK CCCCCCCCCCCCCCC	32.22	23776212
182	Phosphorylation	TPPVSSPTSRNPKPL CCCCCCCCCCCCCCC	42.12	23776212
183	Phosphorylation	PPVSSPTSRNPKPLP CCCCCCCCCCCCCCC	33.18	30291188
207	Phosphorylation	MSMAAKQSMTSLNYP HHHHHHHHCHHCCCC	24.26	23776212
209	Phosphorylation	MAAKQSMTSLNYPFY HHHHHHCHHCCCCEE	35.00	23776212
210	Phosphorylation	AAKQSMTSLNYPFYA HHHHHCHHCCCCEEE	13.13	23776212
213	Phosphorylation	QSMTSLNYPFYAVSA HHCHHCCCCEEEEEC	10.46	23776212
216	Phosphorylation	TSLNYPFYAVSAPAS HHCCCCEEEEECCCC	11.11	23776212
219	Phosphorylation	NYPFYAVSAPASPTH CCCEEEEECCCCCCC	21.99	23776212
223	Phosphorylation	YAVSAPASPTHHRQF EEEECCCCCCCCCCC	29.31	23776212
225	Phosphorylation	VSAPASPTHHRQFHA EECCCCCCCCCCCCC	28.02	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BZR2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BZR2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BZR2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BZR1_ARATH	BZR1	physical	12427989
HAT1_ARATH	HAT1	physical	24164091
HS902_ARATH	HSP81-2	physical	24374469
HS901_ARATH	HSP90.1	physical	23410833
MAX2_ARATH	MAX2	physical	24369836
ELF6_ARATH	ELF6	physical	18467490
REF6_ARATH	REF6	physical	18467490

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BZR2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY.	19376835 [Abstract]