REF6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REF6_ARATH
• UniProt AC: Q9STM3
• Protein Name: Lysine-specific demethylase REF6 {ECO:0000303|PubMed:15377760}
• Gene Name: REF6 {ECO:0000303|PubMed:15377760}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1360
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3. Demethylates both tri- (H3K27me3) and di-methylated (H3K27me2) H3K27me. [PubMed: 21642989]
• Protein Sequence: MAVSEQSQDVFPWLKSLPVAPEFRPTLAEFQDPIAYILKIEEEASRYGICKILPPLPPPSKKTSISNLNRSLAARAAARVRDGGFGACDYDGGPTFATRQQQIGFCPRKQRPVQRPVWQSGEEYSFGEFEFKAKNFEKNYLKKCGKKSQLSALEIETLYWRATVDKPFSVEYANDMPGSAFIPLSLAAARRRESGGEGGTVGETAWNMRAMSRAEGSLLKFMKEEIPGVTSPMVYVAMMFSWFAWHVEDHDLHSLNYLHMGAGKTWYGVPKDAALAFEEVVRVHGYGEELNPLVTFSTLGEKTTVMSPEVFVKAGIPCCRLVQNPGEFVVTFPGAYHSGFSHGFNFGEASNIATPEWLRMAKDAAIRRAAINYPPMVSHLQLLYDFVLALGSRVPTSINPKPRSSRLKDKARSEGERLTKKLFVQNIIHNNELLSSLGKGSPVALLPQSSSDISVCSDLRIGSHLITNQENPIQLKCEDLSSDSVVVDLSNGLKDTVSVKEKFTSLCERSRNHLASTEKDTQETLSDAERRKNDAAVALSDQRLFSCVTCGVLSFDCVAIVQPKEAAARYLMSADCSFFNDWTAASGSANLGQAARSLHPQSKEKHDVNYFYNVPVQTMDHSVKTGDQKTSTTSPTIAHKDNDVLGMLASAYGDSSDSEEEDQKGLVTPSSKGETKTYDQEGSDGHEEARDGRTSDFNCQRLTSEQNGLSKGGKSSLLEIALPFIPRSDDDSCRLHVFCLEHAAEVEQQLRPFGGINLMLLCHPEYPRIEAEAKIVAEELVINHEWNDTEFRNVTREDEETIQAALDNVEAKGGNSDWTVKLGVNLSYSAILSRSPLYSKQMPYNSIIYKAFGRSSPVASSPSKPKVSGKRSSRQRKYVVGKWCGKVWMSHQVHPFLLEQDLEGEESERSCHLRVAMDEDATGKRSFPNNVSRDSTTMFGRKYCRKRKIRAKAVPRKKLTSFKREDGVSDDTSEDHSYKQQWRASGNEEESYFETGNTASGDSSNQMSDPHKGIIRHKGYKEFESDDEVSDRSLGEEYTVRACAASESSMENGSQHSMYDHDDDDDDIDRQPRGIPRSQQTRVFRNPVSYESEDNGVYQQSGRISISNRQANRMVGEYDSAENSLEERGFCSTGKRQTRSTAKRIAKTKTVQSSRDTKGRFLQEFASGKKNEELDSYMEGPSTRLRVRHQKPSRGSLETKPKKIGKKRSGNASFSRVATEKDVEEKEEEEEEEENEEEECAAYQCNMEGCTMSFSSEKQLMLHKRNICPIKGCGKNFFSHKYLVQHQRVHSDDRPLKCPWKGCKMTFKWAWSRTEHIRVHTGARPYVCAEPDCGQTFRFVSDFSRHKRKTGHSVKKTNKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVSEQSQD ------CCCCCCCCC	25.50	22223895
526	Phosphorylation	KDTQETLSDAERRKN HHHHHHHHHHHHHHH	42.04	30291188
631	Phosphorylation	KTGDQKTSTTSPTIA CCCCCCCCCCCCEEE	36.40	25561503
633	Phosphorylation	GDQKTSTTSPTIAHK CCCCCCCCCCEEECC	32.26	25561503
634	Phosphorylation	DQKTSTTSPTIAHKD CCCCCCCCCEEECCC	21.82	25561503
650	Phosphorylation	DVLGMLASAYGDSSD CHHHHHHHHHCCCCC	20.33	30407730
652	Phosphorylation	LGMLASAYGDSSDSE HHHHHHHHCCCCCCH	20.97	30407730
655	Phosphorylation	LASAYGDSSDSEEED HHHHHCCCCCCHHHH	31.51	30407730
656	Phosphorylation	ASAYGDSSDSEEEDQ HHHHCCCCCCHHHHH	50.31	27531888
658	Phosphorylation	AYGDSSDSEEEDQKG HHCCCCCCHHHHHCC	49.18	27531888
683	Phosphorylation	KTYDQEGSDGHEEAR EEECCCCCCCCCCCC	39.40	23776212
855	Phosphorylation	IYKAFGRSSPVASSP HHHHHCCCCCCCCCC	39.10	19376835
856	Phosphorylation	YKAFGRSSPVASSPS HHHHCCCCCCCCCCC	23.25	19376835
860	Phosphorylation	GRSSPVASSPSKPKV CCCCCCCCCCCCCCC	42.91	19376835
861	Phosphorylation	RSSPVASSPSKPKVS CCCCCCCCCCCCCCC	24.37	19376835
863	Phosphorylation	SPVASSPSKPKVSGK CCCCCCCCCCCCCCC	64.63	27531888
969	Phosphorylation	FKREDGVSDDTSEDH CCCCCCCCCCCCCCC	34.99	19880383
972	Phosphorylation	EDGVSDDTSEDHSYK CCCCCCCCCCCCCHH	38.72	19880383
973	Phosphorylation	DGVSDDTSEDHSYKQ CCCCCCCCCCCCHHH	48.28	19880383
977	Phosphorylation	DDTSEDHSYKQQWRA CCCCCCCCHHHHHHH	46.47	25561503
978	Phosphorylation	DTSEDHSYKQQWRAS CCCCCCCHHHHHHHC	14.92	25561503
992	Phosphorylation	SGNEEESYFETGNTA CCCCCCCCEECCCCC	14.55	30407730
995	Phosphorylation	EEESYFETGNTASGD CCCCCEECCCCCCCC	26.32	30407730
998	Phosphorylation	SYFETGNTASGDSSN CCEECCCCCCCCCCC	24.44	30407730
1000	Phosphorylation	FETGNTASGDSSNQM EECCCCCCCCCCCCC	40.89	30407730
1003	Phosphorylation	GNTASGDSSNQMSDP CCCCCCCCCCCCCCC	34.41	30407730
1004	Phosphorylation	NTASGDSSNQMSDPH CCCCCCCCCCCCCCC	35.50	30407730
1008	Phosphorylation	GDSSNQMSDPHKGII CCCCCCCCCCCCCCC	37.92	30407730
1020	Phosphorylation	GIIRHKGYKEFESDD CCCCCCCCCCCCCCC	16.49	23776212
1025	Phosphorylation	KGYKEFESDDEVSDR CCCCCCCCCCCCCCC	56.53	23776212
1030	Phosphorylation	FESDDEVSDRSLGEE CCCCCCCCCCCCCCE	25.84	23776212
1033	Phosphorylation	DDEVSDRSLGEEYTV CCCCCCCCCCCEEEH	45.80	23776212
1038	Phosphorylation	DRSLGEEYTVRACAA CCCCCCEEEHHHHHC	13.26	23776212
1039	Phosphorylation	RSLGEEYTVRACAAS CCCCCEEEHHHHHCC	13.54	23776212
1089	Phosphorylation	RVFRNPVSYESEDNG EEECCCCCEECCCCC	25.17	23776212
1090	Phosphorylation	VFRNPVSYESEDNGV EECCCCCEECCCCCE	24.57	23776212
1092	Phosphorylation	RNPVSYESEDNGVYQ CCCCCEECCCCCEEE	41.85	30291188
1118	Phosphorylation	ANRMVGEYDSAENSL HHHHHCCCCCCCCCH	14.85	23776212
1120	Phosphorylation	RMVGEYDSAENSLEE HHHCCCCCCCCCHHH	36.26	23776212
1124	Phosphorylation	EYDSAENSLEERGFC CCCCCCCCHHHCCCC	28.76	23776212
1176	Phosphorylation	KKNEELDSYMEGPST CCHHHHHHHHCCCCC	38.72	19880383
1177	Phosphorylation	KNEELDSYMEGPSTR CHHHHHHHHCCCCCC	10.00	19880383
1196	Phosphorylation	HQKPSRGSLETKPKK CCCCCCCCCCCCCCC	23.17	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REF6_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REF6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REF6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BZR2_ARATH	BES1	physical	18467490

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.