MSI4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSI4_ARATH
• UniProt AC: O22607
• Protein Name: WD-40 repeat-containing protein MSI4
• Gene Name: MSI4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 507
• Subcellular Localization: Nucleus .
• Protein Description: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the flowering autonomous pathway which positively regulates flowering by promoting transcriptional repression of the flowering repressor FLC. May promote histone deacetylation at the FLC locus leading to the formation of repressive chromatin structures. Also negatively regulates cold-responsive genes..
• Protein Sequence: MESDEAAAVSPQATTPSGGTGASGPKKRGRKPKTKEDSQTPSSQQQSDVKMKESGKKTQQSPSVDEKYSQWKGLVPILYDWLANHNLVWPSLSCRWGPQLEQATYKNRQRLYLSEQTDGSVPNTLVIANCEVVKPRVAAAEHISQFNEEARSPFVKKYKTIIHPGEVNRIRELPQNSKIVATHTDSPDVLIWDVETQPNRHAVLGAANSRPDLILTGHQDNAEFALAMCPTEPFVLSGGKDKSVVLWSIQDHITTIGTDSKSSGSIIKQTGEGTDKNESPTVGPRGVYHGHEDTVEDVAFSPTSAQEFCSVGDDSCLILWDARTGTNPVTKVEKAHDADLHCVDWNPHDDNLILTGSADNTVRLFDRRKLTANGVGSPIYKFEGHKAAVLCVQWSPDKSSVFGSSAEDGLLNIWDYDRVSKKSDRAAKSPAGLFFQHAGHRDKVVDFHWNASDPWTIVSVSDDCETTGGGGTLQIWRMSDLIYRPEEEVVAELEKFKSHVMTCASKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESDEAAA -------CCCHHHCC	11.39	22223895
3	Phosphorylation	-----MESDEAAAVS -----CCCHHHCCCC	39.18	30291188
10	Phosphorylation	SDEAAAVSPQATTPS CHHHCCCCCCCCCCC	13.43	30291188
14	Phosphorylation	AAVSPQATTPSGGTG CCCCCCCCCCCCCCC	33.71	27643528
15	Phosphorylation	AVSPQATTPSGGTGA CCCCCCCCCCCCCCC	20.62	27643528
17	Phosphorylation	SPQATTPSGGTGASG CCCCCCCCCCCCCCC	48.00	27643528
20	Phosphorylation	ATTPSGGTGASGPKK CCCCCCCCCCCCCCC	32.85	27643528
23	Phosphorylation	PSGGTGASGPKKRGR CCCCCCCCCCCCCCC	57.90	27643528
34	Phosphorylation	KRGRKPKTKEDSQTP CCCCCCCCCCCCCCC	48.47	23776212
38	Phosphorylation	KPKTKEDSQTPSSQQ CCCCCCCCCCCCHHH	36.72	23776212
40	Phosphorylation	KTKEDSQTPSSQQQS CCCCCCCCCCHHHHH	29.14	23776212
42	Phosphorylation	KEDSQTPSSQQQSDV CCCCCCCCHHHHHHH	44.13	23776212
43	Phosphorylation	EDSQTPSSQQQSDVK CCCCCCCHHHHHHHH	32.96	23776212
47	Phosphorylation	TPSSQQQSDVKMKES CCCHHHHHHHHHHHH	39.78	23776212
58	Phosphorylation	MKESGKKTQQSPSVD HHHHCCCCCCCCCHH	35.01	23776212
61	Phosphorylation	SGKKTQQSPSVDEKY HCCCCCCCCCHHHHH	14.88	23776212
63	Phosphorylation	KKTQQSPSVDEKYSQ CCCCCCCCHHHHHHH	47.66	23776212
144	Phosphorylation	VAAAEHISQFNEEAR HHHHHHHHHCCHHHC	30.54	27643528
152	Phosphorylation	QFNEEARSPFVKKYK HCCHHHCCHHHHHCC	29.73	27643528
279	Phosphorylation	EGTDKNESPTVGPRG CCCCCCCCCCCCCCC	34.95	26658240
429	Phosphorylation	KSDRAAKSPAGLFFQ CCHHHHCCCCCEEEC	18.43	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSI4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSI4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSI4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASHH2_ARATH	EFS	genetic	10518493
HDA6_ARATH	HDA6	physical	22102827
HOS1_ARATH	HOS1	physical	22960247
MSI5_ARATH	NFC5	physical	23394836
HOS1_ARATH	HOS1	physical	24220632
HDA6_ARATH	HDA6	physical	24220632
HDA15_ARATH	HDA15	physical	24220632
HDA9_ARATH	HDA9	physical	24220632
HDA5_ARATH	HDA05	physical	24220632
ATM_ARATH	ATM	physical	25600937
DET1_ARATH	DET1	physical	25962685
HDA5_ARATH	HDA05	physical	25922987

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.