ATM_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATM_ARATH
• UniProt AC: Q9M3G7
• Protein Name: Serine/threonine-protein kinase ATM
• Gene Name: ATM
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 3856
• Subcellular Localization: Nucleus .
• Protein Description: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, GR1, and LIG4 in response to DNA double strand breaks. Plays a dual role by activating the DNA damage response at dysfunctional telomeres and yet preventing this activation at functional telomeres. Not required for telomere length homeostasis..
• Protein Sequence: MKLQNPDKKTLREGFSQESSVVALDSGVLAMSGLKCDGKFPVKDVLMEEGGDKVRKIQVSGGNISLVVDFSGARTSSNNFFESNASCVNENLVKGNGYREDETQEFLVGNLVWVMTKYKKWWPGEVVDFKADAKESFMVRSIGQSHLVSWFASSKLKPFKESFEQVLNQRNDNGFFDALQKAMSLLSNSLKLDMTCSCIADGNGIVSAQNITTRKNKPLILREFSVDRLEPKEFVTQLKNIAKCVLNAGVLESTVMQSQLSAFYTLFGHKQIPMAQLHENEGRKSFTAKMSDSKFIGSPSICAGNSRKRFRKEWFRKFVSEVDNVSARDDLVNVPPSDLISKLKLLAVGYNCSEETENIGLFEWFFSKFRISVYHDENAYKMQLANMAGFKDLMLATNANRGTVQKTLKSKKIGKSKMEPLNGVSVADTEQKTFELQISKKSNIESLNGVSVADTEQKTFELQILEKSNIESLNGVSTPNIDHEASKSNNSGKTKINHIIGHSNFPSSVAKVQLAKDFQDKLLVQAPDRKAMTADTLSRPAAILVPDLNSGGNALGTAEFDHMQRPETLIQHNVCPQEEKTPRSTILNFQVTAHQGVSGTQFVSSQPTSYKHFTSADLFTYSGKKKRGRKRKNAEELPIVAHASATTGIPDLNGTNTEPTLVLPQVEPTQRRRRRKKEESPNGLTRGITILFLKFSSQVSMPSRDDLTSTFSAFGPLDSSETHVSEEFSGAQVAFVSSADAIEAVKSLEKANPFGETLVNFRLQQKLITVQRNIAPRMPVISHVSPVPKPNNIPTSMDAMRQNLLMMTAMLEKSGDSLSRETKAKLKSEITGLLEKDGVKLLNTWLEGERSITFCRFLSQNTAKLKLDEIPNAETWPFLVKLLLQCVSMEVSGSKRRMPKPTFAKTLRVVVQRTEETKFPGVQFPLLSMAKTLFTHVHDILSNTPSFQSEYGTILRHLLEIKEYRFQMRKRTYSSLVLLYMERAETGFCEKNSGQHSQKEEAFRYILTLQSLLENSPGDFPDDLREEIVNGLIHIFSSVRDEGKLSRKLIECVNTFLLKDGPNLGSLSLEIHNAVEQFVFRCWLTTHDKNLKEILVSYGRLQLNLTRDSSESSSLVEQLLDVVTRELDLGSSSSSASWGDTTKDEKLGALSSYQNSLVELAAHVFYRACVNTSRPSLSEKRARRQHIAMRMVDALTEGKWLWCAAFGCLVRNYCARINMDLLIYWFEAICTNFQRLLEDASMRRSYDGLLWTLRSLQGLSSGLSLPDITMDISKSSASSSELDRGWQSIWSSLIHGLATFSSMSVIVDAVLVLLGSIISSNHITVKILPQEVWDHQLFRHIPSEPALYFIACYFSRMGCQGNLQDDLHLRRNLLRAVCAPLSWKVRLTLDERMVQLLPAAAFSLCAGFKVSLPLPKEHLPTPSQWDVCEQIDDVDRERNFGLFECSVEALTRICSNSSKISGCQVPDVVQLPLVLRDPLLHDMDIYFLSIIPEVKEKGPLSDIFMGCALLCHFMHGSYITRKGKGSSSFFLKACQYLLEGLDHAVESVSKSLNDLQRRGSLGFGSDFNEKGSIIVSLRSFTQSPVFSNRRDQNLLGASYDFVIHSLENLLRSFAKVYEEYTEHAWNTHSDTVPSKSLAPDSPEVGRIVDMDLDLAEDTKERDIIAAGGKAVPGLPVSMGNWKLGMVSLISCFSPVLQFPTWDVLYNLLEKESDPKVLENILYHLCKLSCLTSIPKVDDLVIFLDGMLSTQVKMKRNCLNIVTALHVLLHTLSSSRRDSSGVEKNCGLSLKEAESFQVFVQLGAMVNKVSEFGLLGWFGRVKLINCICDLVLLNPQTGQTMIERLLLMLSDSDYRVRFVLARQIGILFQTWDGHEALFQDICSSFGIKLVTSSKEKLVTAKDVLAVGPQPRQKMETVIITLMHLAYHSENIELQAVFMMCAVSAKDPCQRELIIAALDNLSAQLHYPSRFKYLEELLGPILFHWIASGVSLAGLIETSQLFIPNAEPKYFIHFCSHWLLPALLLHEDHTNLDWVAKMAGQPVVVLVKENFVPIFSICMGLHCSKTSECDKGAMVLQNSILYVGETSENERDKLIKQNMVSIVSFILSCASSSPEPPVPTFSRDTISLAVQTVVDGFLENTDYPKNAAITDRINIFRPDRVFMFITEMHYRMSAACHHRHTRHHLAALEELTILLGHRALVPSSLNYIFNLVGQFIGYPSLQDQCCSIASCLLDLFKSNPAKEIVSVLGDQLQFLVSKLVTCCIDAEADTKISGAKSSQLVNLLHKLVVSSDSSLNEDIRDLEPLPDLKYFQVIRESHIRICEAYSPRNHLLKVEHSTFLIYIFLEILSLSNFLFLSCSTIQQCSRRSNYLPPRFLSRSLQALHNKLIASEVSQEDTNGETAETFWQSDDEIVNAVWTLVRVSASDEADSMRLLVSDFLSRIGIRDPHTVVFHLPGNLVSMHGLQGFGHNTGSKVRSLTENGISDETLITLLNFLKKYLLDDSVKIIDVTSQTLRGILSTERGQQALSSFDSCERALIEVHGRGVNLDIVEKILLDSQKQFKAEKFSLETPEVWSTDNKNFDRWICQLVYCMIALCEDVPIRLCQNIALLKAEISELLFPSVVVSLAGRIGMDINLHDLITSQVKEHIFTDSNKLTKSKQVMLNTLNELRMCYVLERSIFSGQTKREKNSRSCSTAAKIRDVESGSNGMAASITTNWEKVYWLSIDYLVVAGSAVVCGAYLTASMYVEYWCEEKFGNLSLGDPDFSYHDKLPDHVEILVSAITRINEPDSLYGVIHSNKLSAQIITFEHEGNWTRALEYYDLQARSQKMVVPSSLSENLEVEQFQPTTSARHSVFGEGEVQRQPFKGLIRSLQQTGCMHVLDLYCRGLTSREGCFQYDPEFIELQYEAAWRAGKWDFSLLYPQTHCQPLQHAKNNNYHESLHCCLRALQEGDYDGFYGKLKDTKKELVLSISRASEESTEFIYSTVVKLQILHHLGLVWDLRWTTSSHQSVHGYLVKQMACVDPVIPTMDQLSWLNKDWNSIITQTQLHMTLLEPFIAFRRVLLQILGCEKCTMQHLLQSASLLRKGTRFSHAAASLHEFKFLCARSNGQQPVPDWLGKLEEAKLLHAQGRHEVSISLANYILHNYQLKEEASDIYRVIGKWLAETRSSNSRTILEKYLRPAVSLAEEQSSKICKRLVDRQSQTWFHLAHYADALFKSYEERLSSSEWQAALRLRKHKTKELEVFIKRFKSSKKAEQSDYSLKIQDLQKQLTMDKEEAEKLQVDRDNFLKLALEGYKRCLEIGDKYDVRVVFRQVSMWFSLASQKNVIDNMLSTIKEVQSYKFIPLVYQIASRLGSSKDESGSNSFQSALVSLIRKMAIDHPYHTILQLLALANGDRIKDNQRSRNSFVVDMDKKLAAEHLLQDVSHYHGPMIRQMKQLVDIYIKLAELETRREDTNRKVALPREIRSVKQLELVPVVTATIPVDRSCQYNEGSFPFFRGLSDSVTVMNGINAPKVVECFGSDGQKYKQLAKSGNDDLRQDAVMEQFFGLVNTFLHNNRDTWKRRLAVRTYKVIPFTPSAGVLEWVDGTIPLGDYLIGSSRSEGAHGRYGIGNWKYPKCREHMSSAKDKRKAFVDVCTNFRPVMHYFFLEKFLQPADWFVKRLAYTRSVAASSMVGYIVGLGDRHAMNILIDQATAEVVHIDLGVAFEQGLMLKTPERVPFRLTRDIIDGMGITGVEGVFRRCCEETLSVMRTNKEALLTIVEVFIHDPLYKWALSPLKALQRQKETEDYDGMNLEGLQEEFEGNKDATRALMRVKQKLDGYEGGEMRSIHGQAQQLIQDAIDTDRLSHMFPGWGAWM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
892	Phosphorylation	QCVSMEVSGSKRRMP HHHCCCCCCCCCCCC	24.84	28295753
894	Phosphorylation	VSMEVSGSKRRMPKP HCCCCCCCCCCCCCC	18.58	28295753
1641	Phosphorylation	SKSLAPDSPEVGRIV CHHCCCCCCCCCCEE	23.15	30291188
2375	Phosphorylation	YLPPRFLSRSLQALH CCCHHHHHHHHHHHH	19.67	22074104
2377	Phosphorylation	PPRFLSRSLQALHNK CHHHHHHHHHHHHHH	22.81	22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATM_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATM_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATM_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ATM_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.