HDA5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDA5_ARATH
• UniProt AC: Q8RX28
• Protein Name: Histone deacetylase 5
• Gene Name: HDA5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 660
• Subcellular Localization: Nucleus.
• Protein Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity)..
• Protein Sequence: MAMAGESSGKKIGDCDGKVAGNRQRKVGLIYDETMCKHDTPDGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVHTKDHVNLVKSISTKQKDYRRNRIASQLNSIYLNGGSSEAAYLAAGSVVKLAEKVAEGELDCGFAIVRPPGHHAEADEAMGFCLFNNVAVAASFLLNERPDLGVKKILIVDWDVHHGNGTQKMFWKDPRVLFFSVHRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWDQGRCGDADYLAAWDHILIPVAREFNPDVIFLSAGFDAAINDPLGGCCVTPYGYSVMLKKLMEFAQGKIVLALEGGYNLDSIAKSSLACVQVLLEDKQIQGPPEAYPFESTWRVIQAVRKRLCTYWPSLADELSWKLINQKTPTPIILISSSDSETEDNAQGLLDQMSKLSIENPQGTLLENHQVEPASTSWRADLAKVDVWYASFGSNMWKPRFLCYIQGGQVDGLKKVCVGSMDKSPPKETVWETFPHRLFFGRESSVGWGVGGVAFTNPLANLIDQTHMCLYRITLEQFNDVLSQENGLNVDSDSPVFDLAALQLVDNKGSILEAPLNSWYGNVVCLGKERDIPILTMTCTLSAVEKFKSGEIPIRPPAKAYANTLIRGLVEGGRLSKEEAEAYIDKAVSKPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMAGESSG ------CCCCCCCCC	9.13	22223895
396	Phosphorylation	WKLINQKTPTPIILI HHHHCCCCCCCEEEE	23.72	23776212
398	Phosphorylation	LINQKTPTPIILISS HHCCCCCCCEEEEEC	32.14	23776212
404	Phosphorylation	PTPIILISSSDSETE CCCEEEEECCCCCCC	21.97	23776212
405	Phosphorylation	TPIILISSSDSETED CCEEEEECCCCCCCH	31.04	23776212
406	Phosphorylation	PIILISSSDSETEDN CEEEEECCCCCCCHH	38.06	23776212
408	Phosphorylation	ILISSSDSETEDNAQ EEEECCCCCCCHHHH	48.65	23776212
410	Phosphorylation	ISSSDSETEDNAQGL EECCCCCCCHHHHHH	53.22	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDA5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDA5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDA5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
14338_ARATH	GRF8	physical	22363501
14310_ARATH	GRF10	physical	22363501
FLD_ARATH	FLD	physical	25922987
MSI4_ARATH	FVE	physical	25922987
HDA6_ARATH	HDA6	physical	25922987

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.