FLD_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLD_ARATH
• UniProt AC: Q9CAE3
• Protein Name: Protein FLOWERING LOCUS D
• Gene Name: FLD
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 789
• Protein Description: Probable histone demethylase that promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a floral repressor that blocks the transition from vegetative to reproductive development. Probably mediates histone H3 'Lys-4' demethylation at FLC locus. Seems to act in partial redundancy with LDL1 and LDL2 to repress FLC expression. Required for histone H4 deacetylation of FLC locus. May be a component of the histone deacetylase complex..
• Protein Sequence: MVSFSAPKKRRRGRSQRSMSSLNSLPVPNVGLLPGNSNFVSSSASSSGRFNVEVVNGSNQTVKSYPGIGDEIITINKEATTEALLALTAGFPADSLTEEEIEFGVVPIVGGIEQVNYILIRNHIISKWRENISSWVTKEMFLNSIPKHCSSLLDSAYNYLVTHGYINFGIAQAIKDKFPAQSSKSSVIIVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKMEANRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRDKCPLYRVDGKPVDPDVDIKVEVAFNQLLDKASKLRQLMGDVSMDVSLGAALETFRQVSGNDVATEEMGLFNWHLANLEYANAGLVSKLSLAFWDQDDPYDMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVTAGNQVYEGDMVLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDLDTFGHLTEDPNYRGEFFLFYSYAPVAGGALLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGINVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYDILAESVGDGRLFFAGEATTRRYPATMHGAFVTGLREAANMAQSAKARGIRKRIDRNPSRNAHSCAILLADLFRDPDLEFGSFCIIFSRRNPDPKSPAILRVTLSEPRKRNEDPKADQHSNKILFQQLQSHFNQQQQIQVYTLLTRQQALDLREVRGGDEKRLYYLCETLGVKLVGRKGLGVGADSVIASIKAERTGRKLPSSSTSGTKSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Phosphorylation	KDKFPAQSSKSSVII HHHCCCCCCCCEEEE		25368622
183	Phosphorylation	DKFPAQSSKSSVIIV HHCCCCCCCCEEEEE		25368622
185	Phosphorylation	FPAQSSKSSVIIVGA CCCCCCCCEEEEECC		25368622
186	Phosphorylation	PAQSSKSSVIIVGAG CCCCCCCEEEEECCC		25368622
195	Phosphorylation	IIVGAGLSGLAAARQ EEECCCHHHHHHHHH		25368622
287	Sumoylation	VDPDVDIKVEVAFNQ CCCCCCHHHHHHHHH		-
287	Sumoylation	VDPDVDIKVEVAFNQ CCCCCCHHHHHHHHH		-
314	Phosphorylation	GDVSMDVSLGAALET CCHHHCHHHHHHHHH		19880383
321	Phosphorylation	SLGAALETFRQVSGN HHHHHHHHHHHHCCC		19880383
674	Phosphorylation	RRNPDPKSPAILRVT CCCCCCCCCEEEEEE		24894044
693	Sumoylation	RKRNEDPKADQHSNK CCCCCCCCCHHHHHH		-
693	Sumoylation	RKRNEDPKADQHSNK CCCCCCCCCHHHHHH		-
770	Sumoylation	DSVIASIKAERTGRK CHHHHHHHHHHCCCC		-
770	Sumoylation	DSVIASIKAERTGRK CHHHHHHHHHHCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLD_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
287	K	Sumoylation	Sumoylated at Lys-287, Lys-693 and Lys-770 by SIZ1.	18069938
693	K	Sumoylation	Sumoylated at Lys-287, Lys-693 and Lys-770 by SIZ1.	18069938
770	K	Sumoylation	Sumoylated at Lys-287, Lys-693 and Lys-770 by SIZ1.	18069938

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLD_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDA6_ARATH	HDA6	physical	21398257
HDA5_ARATH	HDA05	physical	25922987

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.