HOS1_ARATH - dbPTM
HOS1_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOS1_ARATH
UniProt AC Q84JU6
Protein Name E3 ubiquitin-protein ligase HOS1
Gene Name HOS1
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 927
Subcellular Localization Nucleus . Cytoplasm . Nuclear after cold treatment. Cytoplasmic when plant are grown or returned to normal growth temperatures.
Protein Description E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways. [PubMed: 16702557 Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels]
Protein Sequence MDTREINGFASAARSISLPTQPNYSSKPVQEALKHLASINLRELCNEAKVERCRATRDLASCGRFVNYVLNPCGHASLCTECCQRCDVCPICRSTLPKFGDRLRLRLYYECVEAGLISRTHEEASQDSDEDEHQLAADVHRLYSLFDVAMNNNLISVVCHYITNVCMDETAVSSDPVIAFLLDEVVVKDWVKRTFRSTLAELQEIYNLETKEMQAWLDKLLRCSKQVAGICSVLEVMESAFKGSVSPQLQDVQTLRENIGKTKQHLDIMVWCIRHGFLDDVRSRYSNFTSWNALVGERKSNAVKRAWPDAVDQSSDCSVQSASLFIEDALENLEREPEYSQEIGADLEVGRLQKDKRSFLRSKIEGTSGSYPFENLRTAADMLFLHGGSDLVVAKQAIFLYYLFDRHWTTPEKYWKHTIDDFAATFGITRHSLLESFVFYLLDDHSEEALQEACRILPEICGPETYPKVAQVLLERDNPETALMVLRWSGRDGVSELVSIGEAVTALRVRVECGLLSEAFTYQRTLCLKVKENNLKNGAVKHASDDLDIWSWTEWMEILVNEFCCLSIRRNLVDRIIELPWNPDEEKYLHRCLLDSATDDPSSAVGSLLVVFYLQRYRYIQAYQVDLRLQKIEEAFVSDNQIGEEVMFRMRSQSHWRKELVDRAIDILPVIQQQQVRSGQFSEMEDASEGAKKSDLPDAPDMITSSVPFATTNSVFLQSANNARAREPVANNGSPFQPGHMIGNASHDLSHGRLFTNANRGQKSEVRSVTKNLKFGEMSTPFKDLNRARGNSQLQGKRTEESSPEVNVDRYIENNMSSPYLRRITANNPVTVKSSSNHLNGSSQKPESTFFGTRMQPDKDNFVDLDDPMDMSSSLKDNNNNVLATESRNNSGGLRWRSDETSDDEDELTSFGSMPVKGRRRRRFAAR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationREINGFASAARSISL
HHCCHHHHHHHHCCC		21.8719880383
15PhosphorylationGFASAARSISLPTQP
HHHHHHHHCCCCCCC		16.2925561503
17PhosphorylationASAARSISLPTQPNY
HHHHHHCCCCCCCCC		29.5525561503
20PhosphorylationARSISLPTQPNYSSK
HHHCCCCCCCCCCCH		63.0525561503
120PhosphorylationEAGLISRTHEEASQD
HHCHHCCCCHHHCCC		27.1823776212
125PhosphorylationSRTHEEASQDSDEDE
CCCCHHHCCCCCCCH		37.4923776212
128PhosphorylationHEEASQDSDEDEHQL
CHHHCCCCCCCHHHH		34.9523776212
244PhosphorylationMESAFKGSVSPQLQD
HHHHHCCCCCHHHHH		21.7325561503
246PhosphorylationSAFKGSVSPQLQDVQ
HHHCCCCCHHHHHHH		14.5027531888
799PhosphorylationSQLQGKRTEESSPEV
CHHCCCCCCCCCCCC		47.8125561503
802PhosphorylationQGKRTEESSPEVNVD
CCCCCCCCCCCCCHH		44.9825561503
803PhosphorylationGKRTEESSPEVNVDR
CCCCCCCCCCCCHHH		28.4930407730
872PhosphorylationLDDPMDMSSSLKDNN
CCCCCCCCHHHCCCC		16.7130407730
873PhosphorylationDDPMDMSSSLKDNNN
CCCCCCCHHHCCCCC		32.8130407730
874PhosphorylationDPMDMSSSLKDNNNN
CCCCCCHHHCCCCCC		31.9330407730
898PhosphorylationSGGLRWRSDETSDDE
CCCCEECCCCCCCCC		32.6019880383
901PhosphorylationLRWRSDETSDDEDEL
CEECCCCCCCCCCCC		42.3123776212
902PhosphorylationRWRSDETSDDEDELT
EECCCCCCCCCCCCH		40.8019880383
909PhosphorylationSDDEDELTSFGSMPV
CCCCCCCHHCCCCCC		21.6923776212
910PhosphorylationDDEDELTSFGSMPVK
CCCCCCHHCCCCCCC		39.9923776212
913PhosphorylationDELTSFGSMPVKGRR
CCCHHCCCCCCCCCC		20.2219376835
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOS1_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOS1_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOS1_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ICE1_ARATHICE1physical
16702557
CONS_ARATHCOphysical
22408073
ICE1_ARATHICE1physical
23010172
MSI4_ARATHFVEphysical
22960247
CONS_ARATHCOphysical
23135282
MSI4_ARATHFVEphysical
24220632
HDA6_ARATHHDA6physical
24220632
HDA15_ARATHHDA15physical
24220632
HDA9_ARATHHDA9physical
24220632
HDA5_ARATHHDA05physical
24220632
SRK2E_ARATHOST1physical
25669882
ICE1_ARATHICE1physical
25669882
ICE1_ARATHICE1physical
17416732
SCRM2_ARATHSCRM2physical
26311645
PHYB_ARATHPHYBphysical
26373454
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOS1_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902, AND MASSSPECTROMETRY.

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