PHYB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHYB_ARATH
• UniProt AC: P14713
• Protein Name: Phytochrome B {ECO:0000303|PubMed:2606345}
• Gene Name: PHYB {ECO:0000303|PubMed:2606345}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1172
• Subcellular Localization: Cytoplasm . Nucleus, nucleoplasm . Nucleus speckle . Cytoplasmic in darkness, but translocated to the nucleus upon illumination, when associated with PAPP5 into speckles.
• Protein Description: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion. Involved in the flowering time regulation. Involved in light-regulated circadian phase control that triggers stomatal aperture, stomatal conductance, and CO(2) assimilation. Implicated in red light perception, and, to a lower extent, in blue light signaling. [PubMed: 12177480 Regulates temperature responses by associating with the promoters of key target genes in a temperature-dependent manner and subsequently repressing their expression probably in a PIF4-dependent manner. Thermal timer that integrates temperature information over the course of the night]
• Protein Sequence: MVSGVGGSGGGRGGGRGGEEEPSSSHTPNNRRGGEQAQSSGTKSLRPRSNTESMSKAIQQYTVDARLHAVFEQSGESGKSFDYSQSLKTTTYGSSVPEQQITAYLSRIQRGGYIQPFGCMIAVDESSFRIIGYSENAREMLGIMPQSVPTLEKPEILAMGTDVRSLFTSSSSILLERAFVAREITLLNPVWIHSKNTGKPFYAILHRIDVGVVIDLEPARTEDPALSIAGAVQSQKLAVRAISQLQALPGGDIKLLCDTVVESVRDLTGYDRVMVYKFHEDEHGEVVAESKRDDLEPYIGLHYPATDIPQASRFLFKQNRVRMIVDCNATPVLVVQDDRLTQSMCLVGSTLRAPHGCHSQYMANMGSIASLAMAVIINGNEDDGSNVASGRSSMRLWGLVVCHHTSSRCIPFPLRYACEFLMQAFGLQLNMELQLALQMSEKRVLRTQTLLCDMLLRDSPAGIVTQSPSIMDLVKCDGAAFLYHGKYYPLGVAPSEVQIKDVVEWLLANHADSTGLSTDSLGDAGYPGAAALGDAVCGMAVAYITKRDFLFWFRSHTAKEIKWGGAKHHPEDKDDGQRMHPRSSFQAFLEVVKSRSQPWETAEMDAIHSLQLILRDSFKESEAAMNSKVVDGVVQPCRDMAGEQGIDELGAVAREMVRLIETATVPIFAVDAGGCINGWNAKIAELTGLSVEEAMGKSLVSDLIYKENEATVNKLLSRALRGDEEKNVEVKLKTFSPELQGKAVFVVVNACSSKDYLNNIVGVCFVGQDVTSQKIVMDKFINIQGDYKAIVHSPNPLIPPIFAADENTCCLEWNMAMEKLTGWSRSEVIGKMIVGEVFGSCCMLKGPDALTKFMIVLHNAIGGQDTDKFPFPFFDRNGKFVQALLTANKRVSLEGKVIGAFCFLQIPSPELQQALAVQRRQDTECFTKAKELAYICQVIKNPLSGMRFANSLLEATDLNEDQKQLLETSVSCEKQISRIVGDMDLESIEDGSFVLKREEFFLGSVINAIVSQAMFLLRDRGLQLIRDIPEEIKSIEVFGDQIRIQQLLAEFLLSIIRYAPSQEWVEIHLSQLSKQMADGFAAIRTEFRMACPGEGLPPELVRDMFHSSRWTSPEGLGLSVCRKILKLMNGEVQYIRESERSYFLIILELPVPRKRPLSTASGSGDMMLMMPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MVSGVGGSGG -----CCCCCCCCCC	39.35	29654922
8	Phosphorylation	MVSGVGGSGGGRGGG CCCCCCCCCCCCCCC	28.47	29654922
23	Phosphorylation	RGGEEEPSSSHTPNN CCCCCCCCCCCCCCC	47.99	25561503
24	Phosphorylation	GGEEEPSSSHTPNNR CCCCCCCCCCCCCCC	36.53	25561503
25	Phosphorylation	GEEEPSSSHTPNNRR CCCCCCCCCCCCCCC	35.40	30407730
27	Phosphorylation	EEPSSSHTPNNRRGG CCCCCCCCCCCCCCC	29.65	25561503
39	Phosphorylation	RGGEQAQSSGTKSLR CCCCCCCCCCCCCCC	33.48	25561503
40	Phosphorylation	GGEQAQSSGTKSLRP CCCCCCCCCCCCCCC	38.10	25561503
74	Phosphorylation	LHAVFEQSGESGKSF HHHHHHHCCCCCCCC	37.01	19880383
77	Phosphorylation	VFEQSGESGKSFDYS HHHHCCCCCCCCCCC	55.86	25561503
80	Phosphorylation	QSGESGKSFDYSQSL HCCCCCCCCCCCCCC	27.20	30407730
83	Phosphorylation	ESGKSFDYSQSLKTT CCCCCCCCCCCCCEE	13.44	25561503
84	Phosphorylation	SGKSFDYSQSLKTTT CCCCCCCCCCCCEEC	18.35	25561503
86	Phosphorylation	KSFDYSQSLKTTTYG CCCCCCCCCCEECCC	26.37	19880383
89	Phosphorylation	DYSQSLKTTTYGSSV CCCCCCCEECCCCCC	29.66	30407730
90	Phosphorylation	YSQSLKTTTYGSSVP CCCCCCEECCCCCCC	19.21	30407730
91	Phosphorylation	SQSLKTTTYGSSVPE CCCCCEECCCCCCCH	30.99	30407730
92	Phosphorylation	QSLKTTTYGSSVPEQ CCCCEECCCCCCCHH	16.96	30407730
94	Phosphorylation	LKTTTYGSSVPEQQI CCEECCCCCCCHHHH	20.11	30407730
95	Phosphorylation	KTTTYGSSVPEQQIT CEECCCCCCCHHHHH	37.01	30407730
102	Phosphorylation	SVPEQQITAYLSRIQ CCCHHHHHHHHHHHH	12.62	30407730
106	Phosphorylation	QQITAYLSRIQRGGY HHHHHHHHHHHCCCC	18.05	30407730
1161	Phosphorylation	KRPLSTASGSGDMML CCCCCCCCCCCCEEE	33.31	25561503
1163	Phosphorylation	PLSTASGSGDMMLMM CCCCCCCCCCEEEEE	29.17	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHYB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHYB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHYB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELF3_ARATH	ELF3	physical	11402161
PHYA_ARATH	PHYA	genetic	15610357
ELF3_ARATH	ELF3	genetic	11402161
PKS1_ARATH	PKS1	genetic	18266898
PIF5_ARATH	PIL6	physical	17827270
PIF3_ARATH	PIF3	physical	17827270
ARR4_ARATH	ARR4	physical	17545225
CRY2_ARATH	CRY2	physical	11089975
PIF3_ARATH	PIF3	physical	11069292
PKS1_ARATH	PKS1	physical	10348744
PIF3_ARATH	PIF3	physical	9845368
PHYB_ARATH	PHYB	physical	15823535
NDK2_ARATH	NDPK2	physical	15561724
PIF3_ARATH	PIF3	physical	15486100
PIF4_ARATH	PIF4	physical	15486100
PIF5_ARATH	PIL6	physical	15486100
PHYC_ARATH	PHYC	physical	15273290
PHYD_ARATH	PHYD	physical	15273290
PHYE_ARATH	PHYE	physical	15273290
COP1_ARATH	COP1	physical	11752373
ARR4_ARATH	ARR4	physical	11691995
PIF1_ARATH	PIL5	physical	15448264
PIF3_ARATH	PIF3	physical	15448264
PIF4_ARATH	PIF4	physical	15448264
PIF3_ARATH	PIF3	physical	16705748
NDK2_ARATH	NDPK2	physical	16705748
CRY1_ARATH	CRY1	physical	22577138
PIF3_ARATH	PIF3	physical	22577138
CDPK1_ARATH	CPK1	physical	22737156
GDU2_ARATH	GDU2	physical	22737156
AB10G_ARATH	AT1G53270	physical	22737156
DNJ21_ARATH	ATERDJ2A	physical	22737156
CNG10_ARATH	CNGC10	physical	22737156
PLST4_ARATH	PGLCT	physical	22737156
VOZ1_ARATH	VOZ1	physical	22904146
VOZ2_ARATH	VOZ2	physical	22904146
PHYB_ARATH	PHYB	physical	24554768
PIF7_ARATH	PIF7	physical	24554768
PHYD_ARATH	PHYD	physical	19286967
PHYE_ARATH	PHYE	physical	19286967
PHYB_ARATH	PHYB	physical	19286967
PIF6_ARATH	PIL2	physical	21601096
PIF3_ARATH	PIF3	physical	23746445
PHYB_ARATH	PHYB	physical	24982198
PIF3_ARATH	PIF3	physical	22849408
SPA1_ARATH	SPA1	physical	25627066
ISPG_ARATH	HDS	physical	23964902
GLGS_ARATH	ADG1	physical	23964902
ATB23_ARATH	AtHB23	physical	23964902
P2C22_ARATH	DBP1	physical	23964902
TKTC2_ARATH	AT2G45290	physical	23964902
ODPB3_ARATH	AT2G34590	physical	23964902
SAHH1_ARATH	MEE58	physical	23964902
JAL4_ARATH	AT1G33790	physical	23964902
KAT1_ARATH	KAT1	physical	23964902
Y2451_ARATH	AT2G14510	physical	23964902
EFTU_ARATH	RABE1b	physical	23964902
CLPB3_ARATH	CLPB3	physical	23964902
PIL1_ARATH	PIL1	physical	23964902
HY5_ARATH	HY5	physical	25999965
PPP5_ARATH	PP5.2	physical	15707897
TA14B_ARATH	GAS41	physical	25849764
TAF14_ARATH	TAF14	physical	25849764
PIF5_ARATH	PIL6	physical	26283376
HOS1_ARATH	HOS1	physical	26373454

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.