PHYD_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHYD_ARATH
• UniProt AC: P42497
• Protein Name: Phytochrome D
• Gene Name: PHYD
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1164
• Protein Description: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion..
• Protein Sequence: MVSGGGSKTSGGEAASSGHRRSRHTSAAEQAQSSANKALRSQNQQPQNHGGGTESTNKAIQQYTVDARLHAVFEQSGESGKSFDYSQSLKTAPYDSSVPEQQITAYLSRIQRGGYTQPFGCLIAVEESTFTIIGYSENAREMLGLMSQSVPSIEDKSEVLTIGTDLRSLFKSSSYLLLERAFVAREITLLNPIWIHSNNTGKPFYAILHRVDVGILIDLEPARTEDPALSIAGAVQSQKLAVRAISHLQSLPSGDIKLLCDTVVESVRDLTGYDRVMVYKFHEDEHGEVVAESKRNDLEPYIGLHYPATDIPQASRFLFKQNRVRMIVDCYASPVRVVQDDRLTQFICLVGSTLRAPHGCHAQYMTNMGSIASLAMAVIINGNEEDGNGVNTGGRNSMRLWGLVVCHHTSARCIPFPLRYACEFLMQAFGLQLNMELQLALQVSEKRVLRMQTLLCDMLLRDSPAGIVTQRPSIMDLVKCNGAAFLYQGKYYPLGVTPTDSQINDIVEWLVANHSDSTGLSTDSLGDAGYPRAAALGDAVCGMAVACITKRDFLFWFRSHTEKEIKWGGAKHHPEDKDDGQRMNPRSSFQTFLEVVKSRCQPWETAEMDAIHSLQLILRDSFKESEAMDSKAAAAGAVQPHGDDMVQQGMQEIGAVAREMVRLIETATVPIFAVDIDGCINGWNAKIAELTGLSVEDAMGKSLVRELIYKEYKETVDRLLSCALKGDEGKNVEVKLKTFGSELQGKAMFVVVNACSSKDYLNNIVGVCFVGQDVTGHKIVMDKFINIQGDYKAIIHSPNPLIPPIFAADENTCCLEWNTAMEKLTGWPRSEVIGKLLVREVFGSYCRLKGPDALTKFMIVLHNAIGGQDTDKFPFPFFDRKGEFIQALLTLNKRVSIDGKIIGAFCFLQIPSPELQQALEVQRRQESEYFSRRKELAYIFQVIKNPLSGLRFTNSLLEDMDLNEDQKQLLETSVSCEKQISKIVGDMDVKSIDDGSFLLERTEFFIGNVTNAVVSQVMLVVRERNLQLIRNIPTEVKSMAVYGDQIRLQQVLAEFLLSIVRYAPMEGSVELHLCPTLNQMADGFSAVRLEFRMACAGEGVPPEKVQDMFHSSRWTSPEGLGLSVCRKILKLMNGGVQYIREFERSYFLIVIELPVPLMMMMPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	LHAVFEQSGESGKSF HHHHHHHCCCCCCCC	37.01	19880383
79	Phosphorylation	VFEQSGESGKSFDYS HHHHCCCCCCCCCCC	55.86	25561503
82	Phosphorylation	QSGESGKSFDYSQSL HCCCCCCCCCCCCCC	27.20	30407730
85	Phosphorylation	ESGKSFDYSQSLKTA CCCCCCCCCCCCCCC	13.44	25561503
86	Phosphorylation	SGKSFDYSQSLKTAP CCCCCCCCCCCCCCC	18.35	25561503
88	Phosphorylation	KSFDYSQSLKTAPYD CCCCCCCCCCCCCCC	26.37	19880383
246	Phosphorylation	KLAVRAISHLQSLPS HHHHHHHHHHHCCCC	19.70	24243849
301	Phosphorylation	KRNDLEPYIGLHYPA CCCCCCCCCCEECCC	9.76	22074104
306	Phosphorylation	EPYIGLHYPATDIPQ CCCCCEECCCCCCCH	10.29	22074104
315	Phosphorylation	ATDIPQASRFLFKQN CCCCCHHHHHHHHCC	20.51	22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHYD_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHYD_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHYD_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHYB_ARATH	PHYB	physical	15273290
PHYE_ARATH	PHYE	physical	15273290
PHYD_ARATH	PHYD	physical	19286967
PHYE_ARATH	PHYE	physical	19286967
PHYB_ARATH	PHYB	physical	19286967

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.