PKS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKS1_ARATH
• UniProt AC: Q9SWI1
• Protein Name: Protein PHYTOCHROME KINASE SUBSTRATE 1
• Gene Name: PKS1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 439
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Description: May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling. Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling. Acts positively in PHOT1 signaling. Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism. Involved in the control of leaf flattening and leaf positioning. Promotes negative root phototropism and negatively regulates root gravitropism. May act by controlling auxin homeostasis..
• Protein Sequence: MVTLTPSSASTPKTSFDFMKNNNSHSSLYVSSSSYLSSKEDALVTTKKLMEPSKTLNMSINPKQEEFGDEKKMVKKAPEDPEIGVFGAEKYFNGDMDSDQGSSVLSLTNPEVERTVVDSKQSAKKSTGTPSVRSESSWNSQSVLLQNKLVNSCNSSFKEKKNSNGQIQKVTNNKKSFLANLGCKCACSDGDSVDVEEKTSVKRSADPNISVITMRSSADMNTELIKIQKQEELSQRKSLEVFGSPVAIEKKSSVVQKKLPLPPWKSRTEEDDTKSEGSDSSSDLFEIEGLTGNPKPFLTRQGSDPASPTCYAPSEVSVEWSIVTASAADFSVMSECATSPVRRNRPTQIPRIPITAKSAPQRRKSSSSSGGNGFLMSCKSHKSVMVSGDLDRRSSMNKTQPSYVPRFPMETTKPKSFETRRRISNSSISHTQSSLLYSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	Phosphorylation	LQNKLVNSCNSSFKE HHHHHHHHCCHHHHH	13.75	25561503
155	Phosphorylation	KLVNSCNSSFKEKKN HHHHHCCHHHHHCCC	41.29	25561503
156	Phosphorylation	LVNSCNSSFKEKKNS HHHHCCHHHHHCCCC	26.75	25561503
216	Phosphorylation	ISVITMRSSADMNTE EEEEEEECCCCCCHH	21.03	25561503
217	Phosphorylation	SVITMRSSADMNTEL EEEEEECCCCCCHHH	20.23	25561503
238	Phosphorylation	EELSQRKSLEVFGSP HHHHHCCCHHHHCCC	31.77	30291188
244	Phosphorylation	KSLEVFGSPVAIEKK CCHHHHCCCEEEECC	12.53	30291188
365	Phosphorylation	SAPQRRKSSSSSGGN CCCCCCCCCCCCCCC	33.37	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKS1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKS1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHOT1_ARATH	PHOT1	physical	16777956
RPT3_ARATH	NPH3	physical	16777956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.