RPT3_ARATH - dbPTM
RPT3_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPT3_ARATH
UniProt AC Q9FMF5
Protein Name Root phototropism protein 3
Gene Name RPT3
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 746
Subcellular Localization Cell membrane
Peripheral membrane protein .
Protein Description May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Signal transducer of the phototropic response and photo-induced movements. Involved in the phot1 pathway under low blue light (LBL) fluence rate and in the phot2 pathway under higher fluence rate of blue light (HBL). Necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Not involved in chloroplast accumulation and translocation..
Protein Sequence MMWESESDGGVGVGGGGGREYGDGVLSSNKHGGVKTDGFELRGQSWFVATDIPSDLLVKIGDMNFHLHKYPLLSRSGKMNRLIYESRDPDPTILILDDLPGGPEAFELASKFCYGVPVDLTATNISGLRCAAEYLEMTEDLEEGNLIFKTEAFLSYVVLSSWRDSILVLKSCEKLSPWAENLQIVRRCSESIAWKACSNPKGIRWAYTGKAPSPSTTNFAGSSPRWNESKDSSFYCSPSRNTNSQPVPPDWWFEDVSILRIDHFVRVITAIKVKGMRFELLGAVIMHYAGKWLPGLIKEGGVAIAPAMSSAIGGGLGLGGDEMSISCGSNSSGGSSGPDWKGGLHMVLSAGKTNGHQDSVACLAGLGISPKDQRMIVESLISIIPPQKDSVTCSFLLRLLRAANMLKVAPALITELEKRVGMQFEQATLQDLLIPGYNNKGETMYDVDLVQRLLEHFLVQEQTEGSSPSRMSPSPSQSMYADIPRGNNNNGGGGGGNNQNAKMRVARLVDSYLTEVARDRNLPLTKFQVLAEALPESARTCDDGLYRAIDSYLKAHPTLSEHERKRLCRVMDCQKLSMDACMHAAQNERLPLRVVVQVLFSEQVKISNALANTSLKESTTLGEAMGTYQPMIPNRKTLIEATPQSFQEGWAAAKKDINTLKFELETVKTKYVELQNEMEVMQRQFEKTGKVKNTPSSSAWTSGWKKLSKLTKMSGQESHDISSGGEQAGVDHPPPRKPRRWRNSIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MMWESESDGGVGVG
-CCCCCCCCCCCCCC		51.3229654922
213PhosphorylationAYTGKAPSPSTTNFA
EEECCCCCCCCCCCC		36.0223776212
215PhosphorylationTGKAPSPSTTNFAGS
ECCCCCCCCCCCCCC		52.8023776212
216PhosphorylationGKAPSPSTTNFAGSS
CCCCCCCCCCCCCCC		29.1923776212
217PhosphorylationKAPSPSTTNFAGSSP
CCCCCCCCCCCCCCC		32.4523776212
222PhosphorylationSTTNFAGSSPRWNES
CCCCCCCCCCCCCCC		33.4723776212
223PhosphorylationTTNFAGSSPRWNESK
CCCCCCCCCCCCCCC		19.9830291188
232PhosphorylationRWNESKDSSFYCSPS
CCCCCCCCCCEECCC		26.5319376835
233PhosphorylationWNESKDSSFYCSPSR
CCCCCCCCCEECCCC		30.3019376835
235PhosphorylationESKDSSFYCSPSRNT
CCCCCCCEECCCCCC		8.2523776212
237PhosphorylationKDSSFYCSPSRNTNS
CCCCCEECCCCCCCC		17.9630291188
239PhosphorylationSSFYCSPSRNTNSQP
CCCEECCCCCCCCCC		23.1323776212
324PhosphorylationGLGGDEMSISCGSNS
CCCCCCEEEECCCCC		14.8724894044
463PhosphorylationHFLVQEQTEGSSPSR
HHCHHCCCCCCCCCC		41.3723776212
466PhosphorylationVQEQTEGSSPSRMSP
HHCCCCCCCCCCCCC		32.6123776212
467PhosphorylationQEQTEGSSPSRMSPS
HCCCCCCCCCCCCCC		37.4423776212
469PhosphorylationQTEGSSPSRMSPSPS
CCCCCCCCCCCCCCC		42.4323776212
472PhosphorylationGSSPSRMSPSPSQSM
CCCCCCCCCCCCCCC		22.5525561503
474PhosphorylationSPSRMSPSPSQSMYA
CCCCCCCCCCCCCEE		29.8525561503
476PhosphorylationSRMSPSPSQSMYADI
CCCCCCCCCCCEECC		38.9425561503
546PhosphorylationRTCDDGLYRAIDSYL
CCCCHHHHHHHHHHH		11.9710542152
722PhosphorylationGQESHDISSGGEQAG
CCCCCCCCCCCCCCC		29.0527532006
723PhosphorylationQESHDISSGGEQAGV
CCCCCCCCCCCCCCC		51.6727532006
744PhosphorylationKPRRWRNSIS-----
CCCCCCCCCC-----		18.6819880383
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPT3_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPT3_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPT3_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHOT1_ARATHPHOT1physical
10542152
GBB_ARATHAGB1physical
24486545
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPT3_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND SER-467, ANDMASS SPECTROMETRY.

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