SAHH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAHH1_ARATH
• UniProt AC: O23255
• Protein Name: Adenosylhomocysteinase 1
• Gene Name: SAHH1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 485
• Protein Description: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Required for DNA methylation-dependent gene silencing..
• Protein Sequence: MALLVEKTSSGREYKVKDMSQADFGRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQTAVLIETLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDATLLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQVDPKKYHKMKERLVGVSEETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRHSLPDGLMRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGLQVLTLEDVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGVKRITIKPQTDRWVFPETKAGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNEKASGKYEKKVYVLPKHLDEKVALLHLGKLGARLTKLSKDQSDYVSIPIEGPYKPPHYRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KTSSGREYKVKDMSQ ECCCCCEEEEEECHH	21.52	23776212
20	Phosphorylation	EYKVKDMSQADFGRL EEEEEECHHHHCCCE	32.14	23776212
44	Phosphorylation	PGLMACRTEFGPSQP CCCEEEECCCCCCCC	35.23	24299221
113	Phosphorylation	VFAWKGETLQEYWWC EEEECCCCHHHEEEE	42.27	24299221
203	Phosphorylation	KERLVGVSEETTTGV HHHHCCCCHHHCHHH	24.64	24299221
236	Phosphorylation	VNDSVTKSKFDNLYG CCCCCCHHHCCCCCC	29.23	24299221
244	S-nitrosylation	KFDNLYGCRHSLPDG HCCCCCCCCCCCCCC	1.92	22115780
268	S-nitrosylation	AGKVAVICGYGDVGK CCEEEEEECCCCHHH	2.49	22115780
370	Phosphorylation	YPGVKRITIKPQTDR CCCEEEEEECCCCCC	27.29	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAHH1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAHH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAHH1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADK1_ARATH	ADK1	physical	21976714

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.