ISPG_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISPG_ARATH
• UniProt AC: F4K0E8
• Protein Name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic
• Gene Name: ISPG
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 741
• Subcellular Localization: Plastid, chloroplast stroma .
• Protein Description: Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Is essential for chloroplast development and required for the salicylic acid (SA)-mediated disease resistance to biotrophic pathogens..
• Protein Sequence: MATGVLPAPVSGIKIPDSKVGFGKSMNLVRICDVRSLRSARRRVSVIRNSNQGSDLAELQPASEGSPLLVPRQKYCESLHKTVRRKTRTVMVGNVALGSEHPIRIQTMTTSDTKDITGTVDEVMRIADKGADIVRITVQGKKEADACFEIKDKLVQLNYNIPLVADIHFAPTVALRVAECFDKIRVNPGNFADRRAQFETIDYTEDEYQKELQHIEQVFTPLVEKCKKYGRAMRIGTNHGSLSDRIMSYYGDSPRGMVESAFEFARICRKLDYHNFVFSMKASNPVIMVQAYRLLVAEMYVHGWDYPLHLGVTEAGEGEDGRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEIDPCRRLANLGTKAAKLQQGVAPFEEKHRHYFDFQRRTGDLPVQKEGEEVDYRNVLHRDGSVLMSISLDQLKAPELLYRSLATKLVVGMPFKDLATVDSILLRELPPVDDQVARLALKRLIDVSMGVIAPLSEQLTKPLPNAMVLVNLKELSGGAYKLLPEGTRLVVSLRGDEPYEELEILKNIDATMILHDVPFTEDKVSRVHAARRLFEFLSENSVNFPVIHHINFPTGIHRDELVIHAGTYAGGLLVDGLGDGVMLEAPDQDFDFLRNTSFNLLQGCRMRNTKTEYVSCPSCGRTLFDLQEISAEIREKTSHLPGVSIAIMGCIVNGPGEMADADFGYVGGSPGKIDLYVGKTVVKRGIAMTEATDALIGLIKEHGRWVDPPVADE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	HKTVRRKTRTVMVGN HHHHHHCCCEEEEEC	29.75	27545962
89	Phosphorylation	TVRRKTRTVMVGNVA HHHHCCCEEEEECEE	20.41	27545962
99	Phosphorylation	VGNVALGSEHPIRIQ EECEECCCCCCEEEE	33.31	27545962
107	Phosphorylation	EHPIRIQTMTTSDTK CCCEEEEEEECCCCC	17.70	27545962
109	Phosphorylation	PIRIQTMTTSDTKDI CEEEEEEECCCCCCC	26.91	27545962
110	Phosphorylation	IRIQTMTTSDTKDIT EEEEEEECCCCCCCC	17.49	27545962
111	Phosphorylation	RIQTMTTSDTKDITG EEEEEECCCCCCCCC	33.83	27545962
113	Phosphorylation	QTMTTSDTKDITGTV EEEECCCCCCCCCCH	30.31	27545962
253	Phosphorylation	IMSYYGDSPRGMVES HHHHHCCCCCHHHHH	16.48	29654922
279	Phosphorylation	DYHNFVFSMKASNPV CCCCEEEEECCCCCE	17.67	19880383
441	Sulfoxidation	ATKLVVGMPFKDLAT HHHHHHCCCHHHHHC	2.08	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISPG_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISPG_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISPG_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of ISPG_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.