HY5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HY5_ARATH
• UniProt AC: O24646
• Protein Name: Transcription factor HY5
• Gene Name: HY5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 168
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes (Probable). Acts coordinately with SPL7 to regulate the microRNA miR408 and its target genes in response to changes in light and copper conditions. [PubMed: 25516599 Regulates the abscisic acid (ABA) signaling pathway. Also involved in root gravitropism]
• Protein Sequence: MQEQATSSLAASSLPSSSERSSSSAPHLEIKEGIESDEEIRRVPEFGGEAVGKETSGRESGSATGQERTQATVGESQRKRGRTPAEKENKRLKRLLRNRVSAQQARERKKAYLSELENRVKDLENKNSELEERLSTLQNENQMLRHILKNTTGNKRGGGGGSNADASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LPSSSERSSSSAPHL CCCCCCCCCCCCCCC	30.44	23111157
22	Phosphorylation	PSSSERSSSSAPHLE CCCCCCCCCCCCCCC	34.24	23111157
23	Phosphorylation	SSSERSSSSAPHLEI CCCCCCCCCCCCCCC	31.59	23111157
24	Phosphorylation	SSERSSSSAPHLEIK CCCCCCCCCCCCCCC	48.01	23111157
36	Phosphorylation	EIKEGIESDEEIRRV CCCCCCCCHHHHHCC	48.69	30291188
55	Phosphorylation	GEAVGKETSGRESGS CCCCCCCCCCCCCCC	39.71	30407730
56	Phosphorylation	EAVGKETSGRESGSA CCCCCCCCCCCCCCC	36.62	30407730
60	Phosphorylation	KETSGRESGSATGQE CCCCCCCCCCCCCCH	36.37	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CIP8	Q9SPL2	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	P43254	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HY5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HY5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYB75_ARATH	PAP1	genetic	18182030
COP1_ARATH	COP1	physical	10990463
COP1_ARATH	COP1	physical	9755158
HYH_ARATH	HYH	physical	12023303
COP1_ARATH	COP1	physical	9659918
FHY3_ARATH	FHY3	physical	21097709
FAR1_ARATH	FAR1	physical	21097709
COP1_ARATH	COP1	physical	21097709
BBX21_ARATH	STH2	physical	21950734
HYH_ARATH	HYH	physical	22692212
GBF1_ARATH	GBF1	physical	22692212
PIF1_ARATH	PIL5	physical	23645630
PIF3_ARATH	PIF3	physical	23645630
BBX25_ARATH	STH	physical	23624715
HY5_ARATH	HY5	physical	19457242
HYH_ARATH	HYH	physical	19802365
HY5_ARATH	HY5	physical	19802365
COP1_ARATH	COP1	physical	19802365
ERF16_ARATH	AT5G21960	physical	19802365
PIF3_ARATH	PIF3	physical	19802365
GBF2_ARATH	GBF2	physical	19802365
BH107_ARATH	AT3G56770	physical	19802365
LAF1_ARATH	MYB18	genetic	23503597
HFR1_ARATH	HFR1	physical	23503597
LAF1_ARATH	MYB18	physical	23503597
CALM7_ARATH	CAM7	genetic	25763709
CCA1_ARATH	CCA1	physical	20031914
BZR1_ARATH	BZR1	physical	26363272

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY.
PubMed: 19376835

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY.
PubMed: 18433157