FHY3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FHY3_ARATH
• UniProt AC: Q9LIE5
• Protein Name: Protein FAR-RED ELONGATED HYPOCOTYL 3
• Gene Name: FHY3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 839
• Subcellular Localization: Nucleus .
• Protein Description: Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3'. Activates the expression of FHY1 and FHL involved in light responses. When associated with PHYA, protects it from being recognized and degraded by the COP1/SPA complex. Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression..
• Protein Sequence: MDIDLRLHSGDLCKGDDEDRGLDNVLHNEEDMDIGKIEDVSVEVNTDDSVGMGVPTGELVEYTEGMNLEPLNGMEFESHGEAYSFYQEYSRAMGFNTAIQNSRRSKTTREFIDAKFACSRYGTKREYDKSFNRPRARQSKQDPENMAGRRTCAKTDCKASMHVKRRPDGKWVIHSFVREHNHELLPAQAVSEQTRKIYAAMAKQFAEYKTVISLKSDSKSSFEKGRTLSVETGDFKILLDFLSRMQSLNSNFFYAVDLGDDQRVKNVFWVDAKSRHNYGSFCDVVSLDTTYVRNKYKMPLAIFVGVNQHYQYMVLGCALISDESAATYSWLMETWLRAIGGQAPKVLITELDVVMNSIVPEIFPNTRHCLFLWHVLMKVSENLGQVVKQHDNFMPKFEKCIYKSGKDEDFARKWYKNLARFGLKDDQWMISLYEDRKKWAPTYMTDVLLAGMSTSQRADSINAFFDKYMHKKTSVQEFVKVYDTVLQDRCEEEAKADSEMWNKQPAMKSPSPFEKSVSEVYTPAVFKKFQIEVLGAIACSPREENRDATCSTFRVQDFENNQDFMVTWNQTKAEVSCICRLFEYKGYLCRHTLNVLQCCHLSSIPSQYILKRWTKDAKSRHFSGEPQQLQTRLLRYNDLCERALKLNEEASLSQESYNIAFLAIEGAIGNCAGINTSGRSLPDVVTSPTQGLISVEEDNHSRSAGKTSKKKNPTKKRKVNPEQDVMPVAAPESLQQMDKLSPRTVGIESYYGTQQSVQGMVQLNLMGPTRDNFYGNQQTMQGLRQLNSIAPSYDSYYGPQQGIHGQGVDFFRPANFSYDIRDDPNVRTTQLHEDASRHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	DIDLRLHSGDLCKGD CCEEEEECCCCCCCC	38.30	25561503
680	Phosphorylation	GINTSGRSLPDVVTS CCCCCCCCCCCCCCC	48.02	23776212
686	Phosphorylation	RSLPDVVTSPTQGLI CCCCCCCCCCCCCCE	28.92	23776212
687	Phosphorylation	SLPDVVTSPTQGLIS CCCCCCCCCCCCCEE	17.84	23776212
689	Phosphorylation	PDVVTSPTQGLISVE CCCCCCCCCCCEEEE	34.73	23776212
694	Phosphorylation	SPTQGLISVEEDNHS CCCCCCEEEECCCCC	28.63	23776212
701	Phosphorylation	SVEEDNHSRSAGKTS EEECCCCCCCCCCCC	33.90	23776212
741	Phosphorylation	LQQMDKLSPRTVGIE HHHHHHCCCCEECCE	20.34	30291188
836	Phosphorylation	TQLHEDASRHS---- HHCCCCHHCCC----	42.73	25561503
839	Phosphorylation	HEDASRHS------- CCCHHCCC-------	40.58	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FHY3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FHY3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FHY3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FHY3_ARATH	FHY3	physical	11889039
FAR1_ARATH	FAR1	physical	11889039
PHYA_ARATH	PHYA	physical	18722184
FHY3_ARATH	FHY3	physical	18715961
FAR1_ARATH	FAR1	physical	18715961
HY5_ARATH	HY5	physical	21097709
FAR1_ARATH	FAR1	physical	21097709
LHY_ARATH	LHY	physical	21499259
CCA1_ARATH	CCA1	physical	21499259
HY5_ARATH	HY5	physical	21499259
PIF1_ARATH	PIL5	physical	22634759
HY5_ARATH	HY5	physical	23150635

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.