PHYA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHYA_ARATH
• UniProt AC: P14712
• Protein Name: Phytochrome A {ECO:0000303|PubMed:2606345}
• Gene Name: PHYA {ECO:0000303|PubMed:2606345}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1122
• Subcellular Localization: Cytoplasm . Nucleus, nucleoplasm . Nucleus speckle . Cytoplasmic in darkness, but translocated to the nucleus upon illumination, when associated with PAPP5 into speckles.
• Protein Description: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion. Involved in the flowering time regulation. Can phosphorylate FHY1 and, possibly, FHL, in red light conditions; this inactivates their co-shuttling to the nucleus. [PubMed: 19208901 Regulates phototropic responses both in the nucleus (e.g. hypocotyl elongation and cotyledon opening under high-irradiance conditions and seed germination under very-low-fluence conditions) and in the cytoplasm (e.g. negative gravitropism in blue light and red-enhanced phototropism)]
• Protein Sequence: MSGSRPTQSSEGSRRSRHSARIIAQTTVDAKLHADFEESGSSFDYSTSVRVTGPVVENQPPRSDKVTTTYLHHIQKGKLIQPFGCLLALDEKTFKVIAYSENASELLTMASHAVPSVGEHPVLGIGTDIRSLFTAPSASALQKALGFGDVSLLNPILVHCRTSAKPFYAIIHRVTGSIIIDFEPVKPYEVPMTAAGALQSYKLAAKAITRLQSLPSGSMERLCDTMVQEVFELTGYDRVMAYKFHEDDHGEVVSEVTKPGLEPYLGLHYPATDIPQAARFLFMKNKVRMIVDCNAKHARVLQDEKLSFDLTLCGSTLRAPHSCHLQYMANMDSIASLVMAVVVNEEDGEGDAPDATTQPQKRKRLWGLVVCHNTTPRFVPFPLRYACEFLAQVFAIHVNKEVELDNQMVEKNILRTQTLLCDMLMRDAPLGIVSQSPNIMDLVKCDGAALLYKDKIWKLGTTPSEFHLQEIASWLCEYHMDSTGLSTDSLHDAGFPRALSLGDSVCGMAAVRISSKDMIFWFRSHTAGEVRWGGAKHDPDDRDDARRMHPRSSFKAFLEVVKTRSLPWKDYEMDAIHSLQLILRNAFKDSETTDVNTKVIYSKLNDLKIDGIQELEAVTSEMVRLIETATVPILAVDSDGLVNGWNTKIAELTGLSVDEAIGKHFLTLVEDSSVEIVKRMLENALEGTEEQNVQFEIKTHLSRADAGPISLVVNACASRDLHENVVGVCFVAHDLTGQKTVMDKFTRIEGDYKAIIQNPNPLIPPIFGTDEFGWCTEWNPAMSKLTGLKREEVIDKMLLGEVFGTQKSCCRLKNQEAFVNLGIVLNNAVTSQDPEKVSFAFFTRGGKYVECLLCVSKKLDREGVVTGVFCFLQLASHELQQALHVQRLAERTAVKRLKALAYIKRQIRNPLSGIMFTRKMIEGTELGPEQRRILQTSALCQKQLSKILDDSDLESIIEGCLDLEMKEFTLNEVLTASTSQVMMKSNGKSVRITNETGEEVMSDTLYGDSIRLQQVLADFMLMAVNFTPSGGQLTVSASLRKDQLGRSVHLANLEIRLTHTGAGIPEFLLNQMFGTEEDVSEEGLSLMVSRKLVKLMNGDVQYLRQAGKSSFIITAELAAANK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SGSRPTQSSEGSRRS CCCCCCCCCCCCCCH	32.60	25561503
10	Phosphorylation	GSRPTQSSEGSRRSR CCCCCCCCCCCCCHH	35.84	25561503
13	Phosphorylation	PTQSSEGSRRSRHSA CCCCCCCCCCHHHCC	22.07	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	P43254	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHYA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHYA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHYB_ARATH	PHYB	genetic	14634162
PKS1_ARATH	PKS1	genetic	18266898
PIF5_ARATH	PIL6	physical	17827270
PIF3_ARATH	PIF3	physical	17827270
PHYB_ARATH	PHYB	genetic	11148293
PHYB_ARATH	PHYB	genetic	17251203
GAI_ARATH	GAI	genetic	17220364
PIF3_ARATH	PIF3	physical	16885032
PKS1_ARATH	PKS1	physical	10348744
CRY1_ARATH	CRY1	physical	9651577
NDK2_ARATH	NDPK2	physical	15561724
PIF1_ARATH	PIL5	physical	15448264
NDK2_ARATH	NDPK2	physical	16705748
PIF3_ARATH	PIF3	physical	16705748
COP1_ARATH	COP1	physical	15031264
COP1_ARATH	COP1	physical	22498774
PHYA_ARATH	PHYA	physical	19286967
PIF1_ARATH	PIL5	physical	21884939
PHYA_ARATH	PHYA	physical	21884939
PIF3_ARATH	PIF3	physical	23746445
SPA1_ARATH	SPA1	physical	25627066
PHYA_ARATH	PHYA	physical	19208901
PPP5_ARATH	PP5.2	physical	15707897

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.