SPA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPA1_ARATH
• UniProt AC: Q9SYX2
• Protein Name: Protein SUPPRESSOR OF PHYA-105 1
• Gene Name: SPA1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1029
• Subcellular Localization: Nucleus speckle . Nucleus . Nucleus, PML body . Present in nuclear bodies (NBs).
• Protein Description: Controls normal photoperiodic flowering and regulates circadian rhythms. Required for suppression of photomorphogenesis in dark-grown seedlings and for normal elongation growth of adult plants. Integral component of the COP1/SPA E3 ubiquitin-protein ligase complex. Involved in HY5, HFR1, LAF1 and CO degradation..
• Protein Sequence: MPVMERVAEETVATNNIQLKARVDDVPCNKLDARHNDMVIQSETANSDCPGSSAHRNVDLTKPPPPEEAAGAKLSVEELTLGNYRIVQGSNNTNVDSPRAGKFEHLYRLARGSAFRAGDGDLDSQPRDMDQMLSRIRQQLAGAPSERQNLKPFMSRRSDQNLEAFSERLRAAGENSIMNAPALISEGVQMKTPVSSSNFSQLLLKRAMKGKGVVGKNQETPPEFVSDQDLGSKEKKLDISKSPTPHDVLPLKSSPKGNGMVSHGDGNHSKSSIGISLREFLRSSYAKREKRHGLCLFRQLVELVDSAHSKRLFLLDLRPSLFTLVPSKKLRYIGNFGKNDLESDVDEDLNRRRPVVEESSSGGRDSKKRKMDLHLNSPGNQLQATSTGRPFKRKSPVIDLNMVDARNPDSCELQQQDYIKNLSVSSVSRKQSMSTWLEEQWYTCPEEINGEDIGEKSNIYALGVLLFELLCHCESGEMHAAMMADLRHRILPPTFLSKYPKEAGFCLWLLHPEPSSRPSARDILKSELICEDDSVKSTAAAEEISELLLHFLSSLEVQKKKKASKLLQDIQTLEDDIKEAERRYSSNVSLVRSHGAIEKRVQSSPLDEHCTTSSALFVPTANTDRLMSNIRQLEDAYFFMRSQINLSSSAATARSDKTLKDRDRCSENQNENQDMSTKGKSSDQLEVFFEGLCKFARYSKFETCGTIRSGDLLNSASVVCSLSFDPDEEHIAAAGISKKIKIFDFNAFMNESVGVHYPLVEMVNKSKLSCVCWNSYIKNYLASTDYDGVVQIWDAGTGQGFSQYTEHQKRAWSVDFSPSDPTKFVSGSDDCSVKLWSINEKRSLGTIWSPANVCCVQFSSYSNHLLAFGSADYKVYCYDLRYVKTPWCTLAGHEKAVSYVKFMDSETIVSASTDNSLKLWNLNKTNSSGLSPGACSLTYKGHTNQKNFVGLSVLDGYIACGSETNEVYSYYKSLPMPMTSYKFGSVDPISGNEYFDDNGQFVSSVCWRKKSNMLVAANSTGNMKLLKLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
97	Phosphorylation	SNNTNVDSPRAGKFE CCCCCCCCCCCCHHH	16.41	23111157
158	Phosphorylation	KPFMSRRSDQNLEAF HHHHCCCCHHHHHHH	42.30	29654922
166	Phosphorylation	DQNLEAFSERLRAAG HHHHHHHHHHHHHHH	28.93	29654922
242	Phosphorylation	KKLDISKSPTPHDVL CCCCCCCCCCCCCCC	27.50	25561503
343	Phosphorylation	FGKNDLESDVDEDLN CCCCCHHCCCCHHHH	50.67	30291188
628	Phosphorylation	ANTDRLMSNIRQLED CCHHHHHHHHHHHHH	33.43	19880383
1011	Phosphorylation	SVCWRKKSNMLVAAN EEEEEECCCEEEEEE	30.43	24243849
1019	Phosphorylation	NMLVAANSTGNMKLL CEEEEEECCCCCEEE	32.72	19880383
1020	Phosphorylation	MLVAANSTGNMKLLK EEEEEECCCCCEEEE	32.17	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPA1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPA1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CONS_ARATH	CO	physical	16854975
COP1_ARATH	COP1	physical	14597662
COP1_ARATH	COP1	physical	11461903
COP1_ARATH	COP1	physical	18722184
SPA1_ARATH	SPA1	physical	18812498
SPA2_ARATH	SPA2	physical	18812498
SPA3_ARATH	SPA3	physical	18812498
SPA4_ARATH	SPA4	physical	18812498
COP1_ARATH	COP1	physical	18812498
CRY1_ARATH	CRY1	physical	22577138
PHYB_ARATH	PHYB	physical	23371951
COP1_ARATH	COP1	physical	24067658
COP1_ARATH	COP1	physical	21511872
CRY2_ARATH	CRY2	physical	21511872
PHYA_ARATH	PHYA	physical	25627066
PHYB_ARATH	PHYB	physical	25744387
PHYA_ARATH	PHYA	physical	25744387
PHYB_ARATH	PHYB	genetic	25744387
PHYA_ARATH	PHYA	genetic	25744387
COP1_ARATH	COP1	physical	25744387
PIF1_ARATH	PIL5	physical	24858936
PHYB_ARATH	PHYB	physical	26120968

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.