CRY1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRY1_ARATH
• UniProt AC: Q43125
• Protein Name: Cryptochrome-1 {ECO:0000303|PubMed:8953250}
• Gene Name: CRY1 {ECO:0000303|PubMed:8953250}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 681
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus, PML body . The nuclear pool is involved in hypocotyl and petiole growth inhibition and anthocyanin production, while the cytoplasmic pool is involved in root growth and cotyledon expansion (PubMed:18003924). Present in
• Protein Description: Photoreceptor that mediates primarily blue light inhibition of hypocotyl elongation and photoperiodic control of floral initiation, and regulates other light responses, including circadian rhythms, tropic growth, stomata opening, guard cell development, root development, bacterial and viral pathogen responses, abiotic stress responses, cell cycles, programmed cell death, apical dominance, fruit and ovule development, seed dormancy, and magnetoreception. Photoexcited cryptochromes interact with signaling partner proteins to alter gene expression at both transcriptional and post-translational levels and, consequently, regulate the corresponding metabolic and developmental programs. [PubMed: 21841916 Blue-light absorbing flavoprotein that activates reversible flavin photoreduction via an electron transport chain comprising a tryptophan triad (W-324, W-377 and W-400), accompanied by a large conformational change upon photoexcitation, or via an alternative electron transport that involves small metabolites, including NADPH, NADH, and ATP. The half-life of the activated signaling state is about 5 minutes]
• Protein Sequence: MSGSVSGCGSGGCSIVWFRRDLRVEDNPALAAAVRAGPVIALFVWAPEEEGHYHPGRVSRWWLKNSLAQLDSSLRSLGTCLITKRSTDSVASLLDVVKSTGASQIFFNHLYDPLSLVRDHRAKDVLTAQGIAVRSFNADLLYEPWEVTDELGRPFSMFAAFWERCLSMPYDPESPLLPPKKIISGDVSKCVADPLVFEDDSEKGSNALLARAWSPGWSNGDKALTTFINGPLLEYSKNRRKADSATTSFLSPHLHFGEVSVRKVFHLVRIKQVAWANEGNEAGEESVNLFLKSIGLREYSRYISFNHPYSHERPLLGHLKFFPWAVDENYFKAWRQGRTGYPLVDAGMRELWATGWLHDRIRVVVSSFFVKVLQLPWRWGMKYFWDTLLDADLESDALGWQYITGTLPDSREFDRIDNPQFEGYKFDPNGEYVRRWLPELSRLPTDWIHHPWNAPESVLQAAGIELGSNYPLPIVGLDEAKARLHEALSQMWQLEAASRAAIENGSEEGLGDSAEVEEAPIEFPRDITMEETEPTRLNPNRRYEDQMVPSITSSLIRPEEDEESSLNLRNSVGDSRAEVPRNMVNTNQAQQRRAEPASNQVTAMIPEFNIRIVAESTEDSTAESSSSGRRERSGGIVPEWSPGYSEQFPSEENGIGGGSTTSSYLQNHHEILNWRRLSQTG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
506	Phosphorylation	RAAIENGSEEGLGDS HHHHHCCCCCCCCCC	44.02	30291188
513	Phosphorylation	SEEGLGDSAEVEEAP CCCCCCCCCCEECCC	25.24	23776212
565	Phosphorylation	PEEDEESSLNLRNSV CCCCCCCCCCCCCCC	25.26	19880383
616	Phosphorylation	NIRIVAESTEDSTAE EEEEEEECCCCCCCC	27.62	25368622
617	Phosphorylation	IRIVAESTEDSTAES EEEEEECCCCCCCCC	35.00	25368622
620	Phosphorylation	VAESTEDSTAESSSS EEECCCCCCCCCCCC	24.24	25368622
621	Phosphorylation	AESTEDSTAESSSSG EECCCCCCCCCCCCC	46.93	25368622
624	Phosphorylation	TEDSTAESSSSGRRE CCCCCCCCCCCCCCC	32.81	25561503
625	Phosphorylation	EDSTAESSSSGRRER CCCCCCCCCCCCCCC	21.74	25368622
626	Phosphorylation	DSTAESSSSGRRERS CCCCCCCCCCCCCCC	46.20	25561503
627	Phosphorylation	STAESSSSGRRERSG CCCCCCCCCCCCCCC	37.96	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	COP1	P43254	PMID:11752373

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRY1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRY1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COP1_ARATH	COP1	physical	11752373
CRY1_ARATH	CRY1	physical	17073458
CRY1_ARATH	CRY1	physical	15805487
SPA1_ARATH	SPA1	physical	21511871
PHYB_ARATH	PHYB	physical	22577138
COP1_ARATH	COP1	physical	24554768
SPA1_ARATH	SPA1	physical	21511872

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.