COP1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COP1_ARATH
• UniProt AC: P43254
• Protein Name: E3 ubiquitin-protein ligase COP1 {ECO:0000303|PubMed:1423630}
• Gene Name: COP1 {ECO:0000303|PubMed:1423630}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 675
• Subcellular Localization: Nucleus . Cytoplasm . Localizes to the nucleus in darkness but is gradually relocated to the cytoplasm upon illumination. Localizes to subnuclear foci (speckle) and in dispersed nuclear localization in the dark.
• Protein Description: E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth). [PubMed: 26474641 Represses CIP7 in darkness]
• Protein Sequence: MEEISTDPVVPAVKPDPRTSSVGEGANRHENDDGGSGGSEIGAPDLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLLDKLLKKTSARHVSKTASPLDQFREALQRGCDVSIKEVDNLLTLLAERKRKMEQEEAERNMQILLDFLHCLRKQKVDELNEVQTDLQYIKEDINAVERHRIDLYRARDRYSVKLRMLGDDPSTRNAWPHEKNQIGFNSNSLSIRGGNFVGNYQNKKVEGKAQGSSHGLPKKDALSGSDSQSLNQSTVSMARKKRIHAQFNDLQECYLQKRRQLADQPNSKQENDKSVVRREGYSNGLADFQSVLTTFTRYSRLRVIAEIRHGDIFHSANIVSSIEFDRDDELFATAGVSRCIKVFDFSSVVNEPADMQCPIVEMSTRSKLSCLSWNKHEKNHIASSDYEGIVTVWDVTTRQSLMEYEEHEKRAWSVDFSRTEPSMLVSGSDDCKVKVWCTRQEASVINIDMKANICCVKYNPGSSNYIAVGSADHHIHYYDLRNISQPLHVFSGHKKAVSYVKFLSNNELASASTDSTLRLWDVKDNLPVRTFRGHTNEKNFVGLTVNSEYLACGSETNEVYVYHKEITRPVTSHRFGSPDMDDAEEEAGSYFISAVCWKSDSPTMLTANSQGTIKVLVLAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	VKPDPRTSSVGEGAN CCCCCCCCCCCCCCC	25.06	25561503
21	Phosphorylation	KPDPRTSSVGEGANR CCCCCCCCCCCCCCC	33.26	25561503
36	Phosphorylation	HENDDGGSGGSEIGA CCCCCCCCCCCCCCC	45.57	30407730
39	Phosphorylation	DDGGSGGSEIGAPDL CCCCCCCCCCCCCCC	29.57	30407730
559	Phosphorylation	VSYVKFLSNNELASA EEEEEECCCCCCCCC	40.52	23776212
565	Phosphorylation	LSNNELASASTDSTL CCCCCCCCCCCCCCE	35.06	23776212
567	Phosphorylation	NNELASASTDSTLRL CCCCCCCCCCCCEEE	30.19	23776212
568	Phosphorylation	NELASASTDSTLRLW CCCCCCCCCCCEEEE	33.41	23776212
570	Phosphorylation	LASASTDSTLRLWDV CCCCCCCCCEEEEEC	29.45	23776212
571	Phosphorylation	ASASTDSTLRLWDVK CCCCCCCCEEEEECC	20.78	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COP1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COP1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COP1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HFR1_ARATH	HFR1	physical	17699755
HFR1_ARATH	HFR1	physical	15741320
HFR1_ARATH	HFR1	physical	15620659
PHYA_ARATH	PHYA	physical	15031264
HY5_ARATH	HY5	physical	14597662
CIP8_ARATH	CIP8	physical	12827204
LAF1_ARATH	MYB18	physical	12827204
SPA1_ARATH	SPA1	physical	11461903
CIP8_ARATH	CIP8	physical	10488108
CONS_ARATH	CO	physical	18296627
CRY1_ARATH	CRY1	physical	18252844
BBX25_ARATH	STH	physical	18796637
SPA1_ARATH	SPA1	physical	18722184
PHYA_ARATH	PHYA	physical	18722184
SPA1_ARATH	SPA1	physical	18812498
SPA2_ARATH	SPA2	physical	18812498
SPA3_ARATH	SPA3	physical	18812498
SPA4_ARATH	SPA4	physical	18812498
ELF3_ARATH	ELF3	physical	19061637
GIGAN_ARATH	GI	physical	19061637
CRY2_ARATH	CRY2	physical	11509693
COP1_ARATH	COP1	physical	11080276
COP1_ARATH	COP1	physical	15084749
COP1_ARATH	COP1	physical	9755158
COP1_ARATH	COP1	physical	8837504
HY5_ARATH	HY5	physical	11226162
BBX24_ARATH	STO	physical	11226162
BBX25_ARATH	STH	physical	11226162
HYH_ARATH	HYH	physical	12023303
CIP8_ARATH	CIP8	physical	12028569
HFR1_ARATH	HFR1	physical	15705947
COL3_ARATH	COL3	physical	16339850
PHYB_ARATH	PHYB	physical	20605855
PHYC_ARATH	PHYC	physical	20605855
PHYD_ARATH	PHYD	physical	20605855
PHYE_ARATH	PHYE	physical	20605855
SCAR1_ARATH	WAVE1	physical	21972261
BBX20_ARATH	AT4G39070	physical	22535582
HY5_ARATH	HY5	physical	22692212
RPP8_ARATH	RPP8	physical	20624951
PHOT2_ARATH	PHOT2	physical	20624951
UVR8_ARATH	UVR8	physical	19165148
HY5_ARATH	HY5	physical	23425305
BIN4_ARATH	BIN4	physical	23573936
SPA1_ARATH	SPA1	physical	24067658
SPA3_ARATH	SPA3	physical	24067658
HY5_ARATH	HY5	genetic	24838976
CRY1_ARATH	CRY1	physical	24554768
CRY2_ARATH	CRY2	physical	24554768
UVR8_ARATH	UVR8	physical	24554768
CONS_ARATH	CO	physical	24554768
HFR1_ARATH	HFR1	physical	24554768
COP1_ARATH	COP1	physical	24554768
HFR1_ARATH	HFR1	physical	19802365
COP1_ARATH	COP1	physical	19802365
HYH_ARATH	HYH	physical	19802365
SPA1_ARATH	SPA1	physical	19802365
COP1_ARATH	COP1	physical	21153370
PHYA_ARATH	PHYA	physical	25627066
SPA1_ARATH	SPA1	physical	25744387
HY5_ARATH	HY5	physical	24610722
HY5_ARATH	HY5	physical	24858936
COP1_ARATH	COP1	physical	24858936
COP1_ARATH	COP1	physical	25817546
CSN1_ARATH	FUS6	physical	19175768
CSN4_ARATH	COP8	physical	19175768
CSN5A_ARATH	CSN5A	physical	19175768
RAX2_ARATH	RAX2	physical	18397371
TRIB1_HUMAN	TRIB1	physical	27041596
SUMO1_ARATH	SUMO1	physical	27128446

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.