| UniProt ID | UVR8_ARATH | |
|---|---|---|
| UniProt AC | Q9FN03 | |
| Protein Name | Ultraviolet-B receptor UVR8 | |
| Gene Name | UVR8 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 440 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytosol. UV-B promotes rapid accumulation of UVR8 in the nucleus. | |
| Protein Description | UV-B specific signaling component that acts as UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.. | |
| Protein Sequence | MAEDMAADEVTAPPRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSVDGASGQHIESSNIDPSSGKSWVSPAERYAVVPDETGLTDGSSKGNGGDISVPQTDVKRVRI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAEDMAADE ------CCCCCCCCC | 22223895 | ||
| 399 | Phosphorylation | IDPSSGKSWVSPAER CCCCCCCCCCCHHHE | 23776212 | ||
| 402 | Phosphorylation | SSGKSWVSPAERYAV CCCCCCCCHHHEEEE | 30291188 | ||
| 407 | Phosphorylation | WVSPAERYAVVPDET CCCHHHEEEECCCCC | 23111157 | ||
| 420 | Phosphorylation | ETGLTDGSSKGNGGD CCCCCCCCCCCCCCC | 23111157 | ||
| 421 | Phosphorylation | TGLTDGSSKGNGGDI CCCCCCCCCCCCCCC | 19880383 | ||
| 433 | Phosphorylation | GDISVPQTDVKRVRI CCCCCCCCCCEECCC | 23111157 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UVR8_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UVR8_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UVR8_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RUP1_ARATH | AT5G52250 | physical | 21041653 | |
| RUP2_ARATH | AT5G23730 | physical | 21041653 | |
| UVR8_ARATH | UVR8 | physical | 22388820 | |
| COP1_ARATH | COP1 | physical | 19165148 | |
| COP1_ARATH | COP1 | physical | 22988111 | |
| RUP1_ARATH | AT5G52250 | physical | 22988111 | |
| RUP2_ARATH | AT5G23730 | physical | 22988111 | |
| COP1_ARATH | COP1 | physical | 23277547 | |
| COP1_ARATH | COP1 | physical | 23653191 | |
| UVR8_ARATH | UVR8 | physical | 23745796 | |
| UVR8_ARATH | UVR8 | physical | 24277841 | |
| COP1_ARATH | COP1 | physical | 24277841 | |
| RUP1_ARATH | AT5G52250 | physical | 24277841 | |
| RUP2_ARATH | AT5G23730 | physical | 24277841 | |
| SPA1_ARATH | SPA1 | physical | 24277841 | |
| SPA2_ARATH | SPA2 | physical | 24277841 | |
| SPA3_ARATH | SPA3 | physical | 24277841 | |
| SPA4_ARATH | SPA4 | physical | 24277841 | |
| COP1_ARATH | COP1 | physical | 24554768 | |
| COP1_ARATH | COP1 | physical | 24651064 | |
| RUP2_ARATH | AT5G23730 | physical | 24651064 | |
| COP1_ARATH | COP1 | physical | 25627067 | |
| RUP1_ARATH | AT5G52250 | physical | 25627067 | |
| RUP2_ARATH | AT5G23730 | physical | 25627067 | |
| UVR8_ARATH | UVR8 | physical | 25627067 | |
| COP1_ARATH | COP1 | physical | 25817546 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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