SPA2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPA2_ARATH
• UniProt AC: Q9T014
• Protein Name: Protein SPA1-RELATED 2
• Gene Name: SPA2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1036
• Subcellular Localization: Nucleus .
• Protein Description: Involved in suppression of photomorphogenesis in dark-grown seedlings. Probably part of the COP1/SPA E3 ubiquitin-protein ligase complex..
• Protein Sequence: MMDEGSVGDVSRIDEADVAHLQFKNSEQSFKPENIEVREVKEVQVQREAGSPDCSYGVIADFLDGKNGGDHVELIGNEPCSSRQNTNDEGDVVEELTVKTCEGSSMAIVGRPSSRARLEMNRSQFLHRFPLDGDLPGSSSMSKKVIDRGTVSILRNAGKMSLPETSNGQLAIIAVNGEANEHLTNVERNPVPVEALSHEGIKTKMLSQSGFSQFFVRKTLKGKGVTFRGPPNNRSKARNMDQQTVASSGSALVIANTSAKISSSIPLAAYDGLPCLPSNTSKPSSCANPSDTHRGCGGEGLSLREWLKSERQEVNKAECMYIFRQIVDHVDCSHSQGVVLCDLRPSSFKIFKENAVKYVVSGSQRESFDSNMNKETLSQLENPLVRRRLGDTSSLSIPAKKQKSSGPSSRQWPMFQRAGGVNIQTENNDGAIQEFHFRSSQPHCSTVACPFTSVSEQLEEKWYASPEELRGDMRSASSNIYSLGILLYELLSQFQCERAREAAMSDIRHRILPPKFLSENPKEAGFCLWLLHPESSCRPSTRDILQSEVVNGIPDLYAEGLSLSIEQEDTESELLQHFLFLSQEKRQKHAGNLMEEIASVEADIEEIVKRRCAIGPPSLEEASSSSPASSVPEMRLIRNINQLESAYFAARIDAHLPEARYRLRPDRDLLRNSDNTVAEVENSETWSSDDRVGAFFDGLCKYARYSKFETRGVLRTSELNNTSNVICSLGFDRDEDYFATAGVSKKIKIYEFNSLFNESVDIHYPAIEMPNRSKLSGVCWNNYIRNYLASSDYDGIVKLWDVTTGQAISHFIEHEKRAWSVDFSEACPTKLASGSDDCSVKLWNINERNCLGTIRNIANVCCVQFSPQSSHLLAFGSSDFRTYCYDLRNLRTPWCILSGHNKAVSYAKFLDNETLVTASTDNTLKLWDLKKTTHGGLSTNACSLTFGGHTNEKNFVGLSTSDGYIACGSETNEVYAYHRSLPMPITSYKFGSIDPISGKEIEEDNNLFVSSVCWRKRSNMVVSASSNGSIKVLQLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	QVQREAGSPDCSYGV ECHHHCCCCCCCCEE	25.31	30291188
55	Phosphorylation	EAGSPDCSYGVIADF HCCCCCCCCEEEEHH	32.10	23572148
505	Phosphorylation	RAREAAMSDIRHRIL HHHHHHHHHHHHHCC	25.76	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPA2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPA2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPA2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CONS_ARATH	CO	physical	16854975
SPA1_ARATH	SPA1	physical	18812498
SPA2_ARATH	SPA2	physical	18812498
SPA3_ARATH	SPA3	physical	18812498
SPA4_ARATH	SPA4	physical	18812498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.