| UniProt ID | BIN4_ARATH | |
|---|---|---|
| UniProt AC | Q9FLU1 | |
| Protein Name | DNA-binding protein BIN4 | |
| Gene Name | BIN4 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 454 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the DNA topoisomerase VI complex. Binds to DNA. Required for chromatin organization and progression of endoreduplication cycles. The loss of BIN4 activates the ATM- and ATR-dependent DNA damage responses in postmitotic cells and induces the ectopic expression of the mitotic G2/M-specific cyclin B1;1 gene in non-dividing cells.. | |
| Protein Sequence | MSSSSREGSPDWLRSYEAPMTTSLLSLSSSDDDSPYRESEVISSLPLPDDDGDDIVVLETESVELLTRKNSETKVVTKQVSIEQVFSRKKKADASLNLEDSCAGKENGNNVDCEKLSSKHKDAQGGADSVWLVSSDSEPSSPIKQEVTVSTEKDADFVLEATEEEPAVKTVRKEKSPKTKSKSSRKTPKEGNSAQEILKTEDKDTDTTIAEQVTPEKSPKTKSKSSRKTPKEENCAQEILKTEDKDKDTDTDTIIAEEVTTDQKIKPSSGSSSRLPLVLSEKVNRTKVLVECEGDSIDLSGDMGAVGRVVVSDTTGDMYLDLKGTIYKSTIIPSRTFCVVNVGQTEAKIEAIMNDFIQLIPQSNVYEAETMVEGTLEGFTFESDDESNKNAKTAVKPADQSVGTEEETNTKAKPKAKAKGETVIGKKRGRPSKEKQPPAKKARNSAPKKPKAKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 205 | Phosphorylation | LKTEDKDTDTTIAEQ HHCCCCCCCCCHHHH | 40.77 | 30407730 | |
| 207 | Phosphorylation | TEDKDTDTTIAEQVT CCCCCCCCCHHHHCC | 23.38 | 30407730 | |
| 208 | Phosphorylation | EDKDTDTTIAEQVTP CCCCCCCCHHHHCCC | 22.47 | 30407730 | |
| 214 | Phosphorylation | TTIAEQVTPEKSPKT CCHHHHCCCCCCCCC | 25.98 | 19880383 | |
| 218 | Phosphorylation | EQVTPEKSPKTKSKS HHCCCCCCCCCCCCC | 29.93 | 19880383 | |
| 242 | Phosphorylation | CAQEILKTEDKDKDT HHHHHHHCCCCCCCC | 46.07 | 24889360 | |
| 249 | Phosphorylation | TEDKDKDTDTDTIIA CCCCCCCCCCCCEEE | 46.68 | 24889360 | |
| 251 | Phosphorylation | DKDKDTDTDTIIAEE CCCCCCCCCCEEEEE | 36.81 | 24889360 | |
| 253 | Phosphorylation | DKDTDTDTIIAEEVT CCCCCCCCEEEEEEC | 19.17 | 19880383 | |
| 327 | Phosphorylation | LDLKGTIYKSTIIPS EECCCEEEEEEECCC | 9.95 | 28295753 | |
| 329 | Phosphorylation | LKGTIYKSTIIPSRT CCCEEEEEEECCCCE | 14.10 | 28295753 | |
| 330 | Phosphorylation | KGTIYKSTIIPSRTF CCEEEEEEECCCCEE | 20.83 | 28295753 | |
| 334 | Phosphorylation | YKSTIIPSRTFCVVN EEEEECCCCEEEEEE | 33.28 | 28295753 | |
| 422 | Phosphorylation | KAKAKGETVIGKKRG CHHHCCCEECCCCCC | 26.54 | 25561503 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BIN4_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIN4_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIN4_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| COP1_ARATH | COP1 | physical | 23573936 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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