CSN4_ARATH - dbPTM
CSN4_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSN4_ARATH
UniProt AC Q8L5U0
Protein Name COP9 signalosome complex subunit 4
Gene Name CSN4
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 397
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex..
Protein Sequence MDEALTNASAIGDQRQKIEQYKLILSSVLSSNDLLQAQRFIDHILSDDVPLVVSRQLLQSFAQELGRLEPETQKEIAQFTLTQIQPRVVSFEEQALVIREKLAGLYESEQEWSKAAQMLSGIDLDSGMRAVDDNFKLSKCIQIARLYLEDDDAVNAEAFINKASFLVSNSQNEVLNLQYKVCYARILDMKRKFLEAALRYYGISQIEQRQIGDEEIDENALEQALSAAVTCTILAGAGPQRSRVLATLYKDERCSKLKIYPILQKVYLERILRRPEIDAFSEELRPHQKASLPDKSTVLDRAMIEHNLLSASKLYTNIRFDELGTLLAIDPRKAEKIAANMIGQDRMRGSIDQEEAVIHFEDDVEELQQWDQQISGLCQALNDILDGMAKKGMSVPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDEALTNA
-------CCHHHHHH
10.6922223895
6Phosphorylation--MDEALTNASAIGD
--CCHHHHHHHHHHH
35.4719880383
9PhosphorylationDEALTNASAIGDQRQ
CHHHHHHHHHHHHHH
23.6119880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CSN4_ARATH !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSN4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSN4_ARATH !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
COL1_ARATHCOL1physical
12724535
CUL1_ARATHCUL1physical
12724535
CSN3_ARATHCOP13physical
12724535
CSN5B_ARATHCSN5Bphysical
12724535
CSN6A_ARATHCSN6Aphysical
12724535
CSN1_ARATHFUS6physical
12615944
CSN2_ARATHFUS12physical
12615944
CSN3_ARATHCOP13physical
12615944
CSN4_ARATHCOP8physical
12615944
CSN8_ARATHCOP9physical
12615944
CSN5A_ARATHCSN5Aphysical
12615944
CSN7_ARATHFUS5physical
12615944
CSN6A_ARATHCSN6Aphysical
12615944
CSN7_ARATHFUS5physical
11742986
CSN5A_ARATHCSN5Aphysical
11742986

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSN4_ARATH

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Related Literatures of Post-Translational Modification

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