PHOT2_ARATH - dbPTM
PHOT2_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHOT2_ARATH
UniProt AC P93025
Protein Name Phototropin-2
Gene Name PHOT2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 915
Subcellular Localization Cell membrane
Peripheral membrane protein .
Protein Description Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Mediates calcium spiking of extra- and intracellular origins in response to blue light. Involved in hypocotyl phototropism. Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence. Regulates stomata opening and photomorphogenesis response of leaf tissue. Not involved in hypocotyl elongation inhibition, anthocyanin accumulation or cotyledon opening..
Protein Sequence MERPRAPPSPLNDAESLSERRSLEIFNPSSGKETHGSTSSSSKPPLDGNNKGSSSKWMEFQDSAKITERTAEWGLSAVKPDSGDDGISFKLSSEVERSKNMSRRSSEESTSSESGAFPRVSQELKTALSTLQQTFVVSDATQPHCPIVYASSGFFTMTGYSSKEIVGRNCRFLQGPDTDKNEVAKIRDCVKNGKSYCGRLLNYKKDGTPFWNLLTVTPIKDDQGNTIKFIGMQVEVSKYTEGVNDKALRPNGLSKSLIRYDARQKEKALDSITEVVQTIRHRKSQVQESVSNDTMVKPDSSTTPTPGRQTRQSDEASKSFRTPGRVSTPTGSKLKSSNNRHEDLLRMEPEELMLSTEVIGQRDSWDLSDRERDIRQGIDLATTLERIEKNFVISDPRLPDNPIIFASDSFLELTEYSREEILGRNCRFLQGPETDQATVQKIRDAIRDQREITVQLINYTKSGKKFWNLFHLQPMRDQKGELQYFIGVQLDGSDHVEPLQNRLSERTEMQSSKLVKATATNVDEAVRELPDANTRPEDLWAAHSKPVYPLPHNKESTSWKAIKKIQASGETVGLHHFKPIKPLGSGDTGSVHLVELKGTGELYAMKAMEKTMMLNRNKAHRACIEREIISLLDHPFLPTLYASFQTSTHVCLITDFCPGGELFALLDRQPMKILTEDSARFYAAEVVIGLEYLHCLGIVYRDLKPENILLKKDGHIVLADFDLSFMTTCTPQLIIPAAPSKRRRSKSQPLPTFVAEPSTQSNSFVGTEEYIAPEIITGAGHTSAIDWWALGILLYEMLYGRTPFRGKNRQKTFANILHKDLTFPSSIPVSLVGRQLINTLLNRDPSSRLGSKGGANEIKQHAFFRGINWPLIRGMSPPPLDAPLSIIEKDPNAKDIKWEDDGVLVNSTDLDIDLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationERPRAPPSPLNDAES
CCCCCCCCCCCCHHH		40.7430291188
16PhosphorylationSPLNDAESLSERRSL
CCCCCHHHHHHHHCE		38.6323776212
18PhosphorylationLNDAESLSERRSLEI
CCCHHHHHHHHCEEE		38.0323776212
22PhosphorylationESLSERRSLEIFNPS
HHHHHHHCEEEECCC		36.2530291188
29PhosphorylationSLEIFNPSSGKETHG
CEEEECCCCCCCCCC		53.4823776212
30PhosphorylationLEIFNPSSGKETHGS
EEEECCCCCCCCCCC		55.9623776212
34PhosphorylationNPSSGKETHGSTSSS
CCCCCCCCCCCCCCC		34.7127545962
37PhosphorylationSGKETHGSTSSSSKP
CCCCCCCCCCCCCCC		19.9427545962
38PhosphorylationGKETHGSTSSSSKPP
CCCCCCCCCCCCCCC		36.9027545962
39PhosphorylationKETHGSTSSSSKPPL
CCCCCCCCCCCCCCC		29.8927545962
40PhosphorylationETHGSTSSSSKPPLD
CCCCCCCCCCCCCCC		38.4227545962
41PhosphorylationTHGSTSSSSKPPLDG
CCCCCCCCCCCCCCC		41.9927545962
42PhosphorylationHGSTSSSSKPPLDGN
CCCCCCCCCCCCCCC		51.6427545962
53PhosphorylationLDGNNKGSSSKWMEF
CCCCCCCCCCCCCHH		32.8023776212
54PhosphorylationDGNNKGSSSKWMEFQ
CCCCCCCCCCCCHHH		44.6023776212
55PhosphorylationGNNKGSSSKWMEFQD
CCCCCCCCCCCHHHC		31.8423776212
63PhosphorylationKWMEFQDSAKITERT
CCCHHHCHHHHHHHH		22.2223776212
88PhosphorylationDSGDDGISFKLSSEV
CCCCCCCEEECCHHH		23.1223111157
98PhosphorylationLSSEVERSKNMSRRS
CCHHHHHHHCCCCCC		18.1825561503
105PhosphorylationSKNMSRRSSEESTSS
HHCCCCCCCCCCCCC		40.7823776212
106PhosphorylationKNMSRRSSEESTSSE
HCCCCCCCCCCCCCC		43.5030291188
109PhosphorylationSRRSSEESTSSESGA
CCCCCCCCCCCCCCC		29.5423776212
110PhosphorylationRRSSEESTSSESGAF
CCCCCCCCCCCCCCC		39.2823776212
111PhosphorylationRSSEESTSSESGAFP
CCCCCCCCCCCCCCH		41.1923776212
112PhosphorylationSSEESTSSESGAFPR
CCCCCCCCCCCCCHH		35.5523776212
114PhosphorylationEESTSSESGAFPRVS
CCCCCCCCCCCHHHH		37.0523776212
121PhosphorylationSGAFPRVSQELKTAL
CCCCHHHHHHHHHHH		21.1530291188
170OtherKEIVGRNCRFLQGPD
HHCCCCCCCCCCCCC		2.91-
170OtherKEIVGRNCRFLQGPD
HHCCCCCCCCCCCCC		2.91-
284PhosphorylationQTIRHRKSQVQESVS
HHHHHHHHHHHHHHC		35.2230291188
289PhosphorylationRKSQVQESVSNDTMV
HHHHHHHHHCCCCCC		17.4719376835
291PhosphorylationSQVQESVSNDTMVKP
HHHHHHHCCCCCCCC		37.9619376835
294PhosphorylationQESVSNDTMVKPDSS
HHHHCCCCCCCCCCC		28.2819376835
300PhosphorylationDTMVKPDSSTTPTPG
CCCCCCCCCCCCCCC		37.8027532006
301PhosphorylationTMVKPDSSTTPTPGR
CCCCCCCCCCCCCCC		43.6227532006
302PhosphorylationMVKPDSSTTPTPGRQ
CCCCCCCCCCCCCCC		40.5227532006
303PhosphorylationVKPDSSTTPTPGRQT
CCCCCCCCCCCCCCC		27.4127532006
305PhosphorylationPDSSTTPTPGRQTRQ
CCCCCCCCCCCCCCC		35.9627532006
313PhosphorylationPGRQTRQSDEASKSF
CCCCCCCCHHHHHHC		33.8425561503
319PhosphorylationQSDEASKSFRTPGRV
CCHHHHHHCCCCCCC		19.9127545962
322PhosphorylationEASKSFRTPGRVSTP
HHHHHCCCCCCCCCC		28.2524043427
327PhosphorylationFRTPGRVSTPTGSKL
CCCCCCCCCCCCCCC		27.5825561503
328PhosphorylationRTPGRVSTPTGSKLK
CCCCCCCCCCCCCCC		23.2419376835
330PhosphorylationPGRVSTPTGSKLKSS
CCCCCCCCCCCCCCC		54.9325561503
332PhosphorylationRVSTPTGSKLKSSNN
CCCCCCCCCCCCCCC		36.9719880383
336PhosphorylationPTGSKLKSSNNRHED
CCCCCCCCCCCCCHH		49.0529654922
355PhosphorylationEPEELMLSTEVIGQR
CHHHHHHHEEECCCC		14.4625368622
356PhosphorylationPEELMLSTEVIGQRD
HHHHHHHEEECCCCC		30.2525368622
364PhosphorylationEVIGQRDSWDLSDRE
EECCCCCCCCCHHHH		25.3630291188
368PhosphorylationQRDSWDLSDRERDIR
CCCCCCCHHHHHHHH		31.9525561503
426OtherEEILGRNCRFLQGPE
HHHHCCCCCCCCCCC		2.91-
426OtherEEILGRNCRFLQGPE
HHHHCCCCCCCCCCC		2.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHOT2_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHOT2_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHOT2_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHOT2_ARATHPHOT2physical
18585389
PKS2_ARATHPKS2physical
20071603
PKS1_ARATHPKS1physical
20071603
RPT3_ARATHNPH3physical
20071603
2AAA_ARATHRCN1physical
20139163
14336_ARATHGRF6physical
22408078
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHOT2_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-22; SER-109;THR-328 AND SER-364, AND MASS SPECTROMETRY.

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