2AAA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2AAA_ARATH
• UniProt AC: Q38845
• Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
• Gene Name: PP2AA1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 588
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Seems to act as a positive regulator of PP2A catalytic activity. Confers resistance to phosphatase inhibitors such as okadaic acid and cantharidin. Involved during developmental process such as seedling and floral developments, root gravitropism, and stomatal opening regulation. Involved in the regulation of auxin efflux, especially during basipetal (tips to base) auxin transport in roots, and appears to contribute to the perception of auxin efflux inhibitors such as 1-N-naphthylphthalamic acid (NPA) and to semicarbazone I (substituted phenylsemicarbazone of 2-acetylarylcarboxylic acids) (SCB-I). Modulates the magnitude of ethylene response in the hypocotyl and stem, and functions as a general positive transducer of early ABA signaling. The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA or B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. [PubMed: 25085430]
• Protein Sequence: MAMVDEPLYPIAVLIDELKNDDIQLRLNSIRRLSTIARALGEERTRKELIPFLSENSDDDDEVLLAMAEELGVFIPFVGGIEFAHVLLPPLESLCTVEETCVREKAVESLCKIGSQMKENDLVESFVPLVKRLAGGEWFAARVSACGIFHVAYQGCTDVLKTELRATYSQLCKDDMPMVRRAAASNLGKFATTVESTFLIAEIMTMFDDLTKDDQDSVRLLAVEGCAALGKLLEPQDCVARILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPDCTRTDLVPAYVRLLRDNEAEVRIAAAGKVTKFCRLLNPELAIQHILPCVKELSSDSSQHVRSALASVIMGMAPILGKDSTIEHLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYVPLLASQLGIGFFDDKLGALCMQWLQDKVYSIREAAANNLKRLAEEFGPEWAMQHLVPQVLDMVNNPHYLHRMMVLRAISLMAPVMGSEITCSKFLPVVVEASKDRVPNIKFNVAKLLQSLIPIVDQSVVDKTIRQCLVDLSEDPDVDVRYFANQALNSIDGSTAAQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AMVDEPLYPIAVLID CCCCCCCHHHHHHHH	11.87	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2AAA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2AAA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2AAA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
2A5B_ARATH	ATB BETA	physical	10091592
FRS3_ARATH	FRS3	physical	21798944
AROD4_ARATH	ADT4	physical	21798944
LIIP1_ARATH	LIP1	physical	21798944
ICLN_ARATH	AT5G62290	physical	21798944
TGA5_ARATH	OBF5	physical	21798944
Y5475_ARATH	AT5G25475	physical	21798944
MSRB3_ARATH	MSRB3	physical	21798944
KAD6_ARATH	AT5G60340	physical	21798944
TTL_ARATH	AT4G24900	physical	21798944
THOC6_ARATH	DWA1	physical	21798944
TAF15_ARATH	TAF15	physical	21798944
MPK3_ARATH	MPK3	physical	21798944
KPRS2_ARATH	PRS2	physical	21798944
2AB2A_ARATH	AT5G44090	physical	21798944
BZR1_ARATH	BZR1	physical	21258370
SRK2D_ARATH	SNRK2.2	physical	26175513
SRK2I_ARATH	SNRK2.3	physical	26175513
SRK2E_ARATH	OST1	physical	26175513

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.