dbPTM

THOC6_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THOC6_ARATH
UniProt AC	Q8L4M1
Protein Name	THO complex subunit 6
Gene Name	THO6
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	367
Subcellular Localization	Nucleus .
Protein Description	Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export.; Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling. May function as the substrate recognition module within this complex leading to ABI5 degradation. Functionally redundant with DWA2..
Protein Sequence	MYGDATNWNEDEYRESILKEREIETRTVFRTAWAPPARISNPDAFVVASSDGTLAFHSLNSLVSQSASFGYSKGQDVMVAEPERVVRAHEGPAYDVKFYGEDEDALLLSCGDDGRVRGWKWREFAESDVSLHLKENHLKPLLELINPQHKGPWGALSPMPEINAMSVDPQSGSVFTAAGDSCAYCWDVESGKIKMTFKGHSDYLHTVVSRSSASQILTGSEDGTARIWDCKTGKCVKVIGSQDKKSRLRVSSMALDGSESWLVCGQGKNLALWNLPASECVQTIPIPAHVQDVMFDEKQILTVGAEPLLRRFDLNGALLSQIHCAPCSVFSISLHPAGVVAVGGYGGIVDVISQFGSHLCTFRSSSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of THOC6_ARATH !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THOC6_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THOC6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THOC6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL4_ARATH	CUL4	physical	20525848
DDB1B_ARATH	DDB1B	physical	20525848
ABI5_ARATH	ABI5	physical	20525848
DWA2_ARATH	DWA2	physical	20525848
THO5B_ARATH	THO5	physical	21798944

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THOC6_ARATH

Related Literatures of Post-Translational Modification