| UniProt ID | SRK2E_ARATH | |
|---|---|---|
| UniProt AC | Q940H6 | |
| Protein Name | Serine/threonine-protein kinase SRK2E | |
| Gene Name | SRK2E | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 362 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomata closure in response to drought, plant pathogens, or decreases in atmospheric relative humidity (RH). Involved in the resistance to drought by avoiding water loss. Required for the stomata closure mediated by pathogen-associated molecular pattern (PAMPs) (e.g. flg22 and LPS) of pathogenic bacteria such as P.syringae pv. tomato (Pst) and E.coli O157:H7. As a plant defense process, stomata are closed transiently in order to limit invaders, but actively reopened by bacteria after a few hours; virulent strains (e.g. Pst DC3000) are more efficient than avirulent strains (e.g. Pst DC3000 AvrRpt2) in reopening stomata. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1, and thus promotes stomata closure. Essential for stomatal closure in response to reactive oxygen species (ROS). Promotes MAPKKK18 activity upon abscisic acid (ABA) treatment. [PubMed: 26443375] | |
| Protein Sequence | MDRPAVSGPMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPAGTQNLNHYLTGSLDIDDDMEEDLESDLDDLDIDSSGEIVYAM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MDRPAVSGPMDLPI -CCCCCCCCCCCCCC | 39.01 | 16766677 | |
| 18 | Phosphorylation | DLPIMHDSDRYELVK CCCCCCCCCCEEEEH | 14.87 | 16766677 | |
| 29 | Phosphorylation | ELVKDIGSGNFGVAR EEEHHHCCCCCHHHH | 30.78 | 30291188 | |
| 43 | Phosphorylation | RLMRDKQSNELVAVK HHHCCCCCCCEEEEE | 37.70 | 16766677 | |
| 151 | Phosphorylation | ENTLLDGSPAPRLKI CCCCCCCCCCCCEEE | 19.97 | 30291188 | |
| 166 | Phosphorylation | CDFGYSKSSVLHSQP CCCCCCHHHHHCCCC | 21.53 | 23776212 | |
| 167 | Phosphorylation | DFGYSKSSVLHSQPK CCCCCHHHHHCCCCC | 32.22 | 23776212 | |
| 171 | Phosphorylation | SKSSVLHSQPKSTVG CHHHHHCCCCCCCCC | 43.98 | 23776212 | |
| 175 | Phosphorylation | VLHSQPKSTVGTPAY HHCCCCCCCCCCCCE | 34.70 | 24601666 | |
| 176 | Phosphorylation | LHSQPKSTVGTPAYI HCCCCCCCCCCCCEE | 29.13 | 23776212 | |
| 179 | Phosphorylation | QPKSTVGTPAYIAPE CCCCCCCCCCEECHH | 10.62 | 23776212 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRK2E_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRK2E_ARATH !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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