CIPKQ_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIPKQ_ARATH
• UniProt AC: Q84VQ3
• Protein Name: CBL-interacting serine/threonine-protein kinase 26
• Gene Name: CIPK26
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 439
• Subcellular Localization: Cell membrane .
• Protein Description: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Involved in the calcium-dependent regulation of reactive oxygen species production by the NADPH oxidase RBOHF..
• Protein Sequence: MNRPKVQRRVGKYEVGKTLGQGTFAKVRCAVNTETGERVALKILDKEKVLKHKMAEQIRREICTMKLINHPNVVRLYEVLASKTKIYIVLEFGTGGELFDKIVHDGRLKEENARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAQGNLKVSDFGLSALSRQVRGDGLLHTACGTPNYAAPEVLNDQGYDGATADLWSCGVILFVLLAGYLPFEDSNLMTLYKKIIAGEYHCPPWLSPGAKNLIVRILDPNPMTRITIPEVLGDAWFKKNYKPAVFEEKEEANLDDVDAVFKDSEEHHVTEKKEEQPTSMNAFELISMSRALDLGNLFEEEEGFKRETRFAAKGAANDLVQKIEEASKPLGFDIQKKNYKMRLENVTAGRKGNLRVATEIFQVSPSLHMIEVRKTKGDTLEFHKFYKKLSTSLNDVVWKSGESSGLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
158	Phosphorylation	KVSDFGLSALSRQVR EHHHHCHHHHHHHHC	27.78	-
172	Phosphorylation	RGDGLLHTACGTPNY CCCCCEECCCCCCCC	24.50	-
378	Phosphorylation	KMRLENVTAGRKGNL EEEEEECCCCCCCCC	34.67	26811356
410	Phosphorylation	VRKTKGDTLEFHKFY EEECCCCCCHHHHHH	36.53	25561503
423	Phosphorylation	FYKKLSTSLNDVVWK HHHHHHCCHHHCHHH	23.07	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIPKQ_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIPKQ_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIPKQ_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBOHF_ARATH	RBOH F	physical	23335733
SRK2D_ARATH	SNRK2.2	physical	25614064
CNBL4_ARATH	SOS3	physical	24970010
CNBL7_ORYSJ	Os02g0291000	physical	24970010
CNBL4_ORYSJ	Os05g0534400	physical	24970010
CNBL5_ORYSJ	Os01g0598200	physical	24970010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.