2AAG_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2AAG_ARATH
• UniProt AC: Q38951
• Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
• Gene Name: PP2AA3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 587
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Involved during developmental process such as seedling and floral developments. Seems to act as a negative regulator of PP2A catalytic activity..
• Protein Sequence: MSMVDEPLYPIAVLIDELKNDDIQRRLNSIKRLSIIARALGEERTRKELIPFLSENNDDDDEVLLAMAEELGGFILYVGGVEYAYVLLPPLETLSTVEETCVREKAVDSLCRIGAQMRESDLVEHFTPLAKRLSAGEWFTARVSACGIFHIAYPSAPDVLKTELRSIYGQLCQDDMPMVRRAAATNLGKFAATIESAHLKTDIMSMFEDLTQDDQDSVRLLAVEGCAALGKLLEPQDCVAHILPVIVNFSQDKSWRVRYMVANQLYELCEAVGPEPTRTDLVPAYARLLCDNEAEVRIAAAGKVTKFCRILNPELAIQHILPCVKELSSDSSQHVRSALASVIMGMAPVLGKDATIEHLLPIFLSLLKDEFPDVRLNIISKLDQVNQVIGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDEKLGALCMQWLQDKVHSIREAAANNLKRLAEEFGPEWAMQHIVPQVLEMINNPHYLYRMTILRAVSLLAPVMGSEITCSKLLPAVITASKDRVPNIKFNVAKMMQSLIPIVDQAVVENMIRPCLVELSEDPDVDVRYFANQALQSIDNVMMSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSMVDEPLY ------CCCCCCCCH	27.75	22223895
2	Phosphorylation	------MSMVDEPLY ------CCCCCCCCH	27.75	19880383
586	Phosphorylation	SIDNVMMSS------ HHHHHHCCC------	18.14	23328941
587	Phosphorylation	IDNVMMSS------- HHHHHCCC-------	26.75	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 2AAG_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2AAG_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2AAG_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASK20_ARATH	SK20	physical	21798944
PUB14_ARATH	PUB14	physical	21798944
2A5N_ARATH	AT3G26020	physical	21798944
BZR1_ARATH	BZR1	physical	21258370

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.