P2C77_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P2C77_ARATH
• UniProt AC: O04719
• Protein Name: Protein phosphatase 2C 77
• Gene Name: ABI2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 423
• Protein Description: Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration. Controls negatively fibrillin that is involved in mediating ABA-induced photoprotection. May be implicated in ABA content regulation. Involved in acquired thermotolerance of root growth and seedling survival. Required for the Erwinia amylovora harpin-induced (HrpN) drought tolerance. Involved in the hydrotropic response..
• Protein Sequence: MDEVSPAVAVPFRPFTDPHAGLRGYCNGESRVTLPESSCSGDGAMKDSSFEINTRQDSLTSSSSAMAGVDISAGDEINGSDEFDPRSMNQSEKKVLSRTESRSLFEFKCVPLYGVTSICGRRPEMEDSVSTIPRFLQVSSSSLLDGRVTNGFNPHLSAHFFGVYDGHGGSQVANYCRERMHLALTEEIVKEKPEFCDGDTWQEKWKKALFNSFMRVDSEIETVAHAPETVGSTSVVAVVFPTHIFVANCGDSRAVLCRGKTPLALSVDHKPDRDDEAARIEAAGGKVIRWNGARVFGVLAMSRSIGDRYLKPSVIPDPEVTSVRRVKEDDCLILASDGLWDVMTNEEVCDLARKRILLWHKKNAMAGEALLPAEKRGEGKDPAAMSAAEYLSKMALQKGSKDNISVVVVDLKGIRKFKSKSLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
185	Phosphorylation	ERMHLALTEEIVKEK HHHHHHHHHHHHHHC	26.43	23820729
386	Phosphorylation	GKDPAAMSAAEYLSK CCCHHHHHHHHHHHH	21.43	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BPM3	O22286	PMID:31308219
-	K	Ubiquitination	E3 ubiquitin ligase	BPM5	Q1EBV6	PMID:31308219

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P2C77_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P2C77_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CIPKF_ARATH	CIPK15	physical	12194854
CIPKO_ARATH	SOS2	physical	14504388
PYL8_ARATH	RCAR3	physical	19769575
PYL5_ARATH	PYL5	physical	21885535
PYL9_ARATH	RCAR1	physical	21885535
SRK2E_ARATH	OST1	physical	21885535
SRK2E_ARATH	OST1	physical	22730405
RAC10_ARATH	RAC10	physical	22908257
MBP_HUMAN	MBP	physical	22968126
SRK2D_ARATH	SNRK2.2	physical	22516825
SRK2I_ARATH	SNRK2.3	physical	22516825
SRK2A_ARATH	AT1G10940	physical	22516825
SRK2H_ARATH	SNRK2.5	physical	22516825
SRK2E_ARATH	OST1	physical	22516825
SRK2F_ARATH	SNRK2.7	physical	22516825
SRK2J_ARATH	SNRK2.9	physical	22516825
SRK2B_ARATH	SNRK2.10	physical	22516825
PYL9_ARATH	RCAR1	physical	19407143
SRK2E_ARATH	OST1	physical	20729862
SRK2E_ARATH	OST1	physical	19924127
SRK2D_ARATH	SNRK2.2	physical	22116026
SRK2I_ARATH	SNRK2.3	physical	22116026
SRK2E_ARATH	OST1	physical	22116026
PYL2_ARATH	PYL2	physical	22116026
BRK1_ARATH	BRK1	physical	17267444
SCAR1_ARATH	WAVE1	physical	17267444
SCAR2_ARATH	SCAR2	physical	17267444
SCAR3_ARATH	WAVE2	physical	17267444
SCARL_ARATH	WAVE5	physical	17267444
SWI3B_ARATH	SWI3B	physical	19033529
CNBL1_ARATH	CBL1	physical	25943353

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.