SRK2I_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRK2I_ARATH
• UniProt AC: Q39193
• Protein Name: Serine/threonine-protein kinase SRK2I
• Gene Name: SRK2I
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 361
• Protein Description: Together with SRK2D, key component and activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as seed germination, Pro accumulation, root growth inhibition, dormancy and seedling growth, and, to a lesser extent, stomatal closure..
• Protein Sequence: MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGDKIDENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRNRCLDDFMTDNLDLDDDMDDFDSESEIDIDSSGEIVYAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	DFVKDIGSGNFGVAR CHHHHHCCCCHHHHH	30.78	30291188
152	Phosphorylation	ENTLLDGSPAPRLKI CCCCCCCCCCCCEEE	19.97	30291188
167	Phosphorylation	CDFGYSKSSVLHSQP CCCCCCHHHHHCCCC	21.53	23776212
168	Phosphorylation	DFGYSKSSVLHSQPK CCCCCHHHHHCCCCC	32.22	23776212
172	Phosphorylation	SKSSVLHSQPKSTVG CHHHHHCCCCCCCCC	43.98	23776212
176	Phosphorylation	VLHSQPKSTVGTPAY HHCCCCCCCCCCCCC	34.70	24601666
177	Phosphorylation	LHSQPKSTVGTPAYI HCCCCCCCCCCCCCC	29.13	23776212
180	Phosphorylation	QPKSTVGTPAYIAPE CCCCCCCCCCCCCHH	10.62	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRK2I_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRK2I_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRK2I_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KSG7_ARATH	BIN2	physical	24928519
CIPKQ_ARATH	AT5G21326	physical	25614064
RAV1_ARATH	RAV1	physical	25231920

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.