KSG7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KSG7_ARATH
• UniProt AC: Q39011
• Protein Name: Shaggy-related protein kinase eta {ECO:0000303|PubMed:9611268}
• Gene Name: ASK7 {ECO:0000303|PubMed:10080716}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 380
• Protein Description: Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5. [PubMed: 11847343]
• Protein Sequence: MADDKEMPAAVVDGHDQVTGHIISTTIGGKNGEPKQTISYMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKNRELQLMRVMDHPNVVCLKHCFFSTTSKDELFLNLVMEYVPESLYRVLKHYSSANQRMPLVYVKLYMYQIFRGLAYIHNVAGVCHRDLKPQNLLVDPLTHQVKICDFGSAKQLVKGEANISYICSRFYRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTREEIRCMNPHYTDFRFPQIKAHPWHKIFHKRMPPEAIDFASRLLQYSPSLRCTALEACAHPFFDELREPNARLPNGRPFPPLFNFKQEVAGSSPELVNKLIPDHIKRQLGLSFLNQSGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	KHCFFSTTSKDELFL ECCCCCCCCCHHHHH	32.36	-
105	Phosphorylation	HCFFSTTSKDELFLN CCCCCCCCCHHHHHH	37.89	-
187	Phosphorylation	VKICDFGSAKQLVKG EEECCCCCHHHHHCC	32.08	-
199	Phosphorylation	VKGEANISYICSRFY HCCCCCHHHHHHHHH	14.30	23776212
200	Phosphorylation	KGEANISYICSRFYR CCCCCHHHHHHHHHC	11.36	30291188
203	Phosphorylation	ANISYICSRFYRAPE CCHHHHHHHHHCCCH	18.83	23776212
220	Phosphorylation	FGATEYTTSIDIWSA CCCCCCCCHHHHHHH	23.84	-
261	Phosphorylation	IKVLGTPTREEIRCM HHHHCCCCHHHHHCC	51.02	-
310	Phosphorylation	RLLQYSPSLRCTALE HHHHHCHHHHHHHHH	23.62	-
314	Phosphorylation	YSPSLRCTALEACAH HCHHHHHHHHHHHCC	28.04	-
353	Phosphorylation	FKQEVAGSSPELVNK CCHHHCCCCHHHHHH	32.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KSG7_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KSG7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KSG7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BZR1_ARATH	BZR1	physical	17873094
ARFB_ARATH	ARF2	physical	18599455
KSG7_ARATH	BIN2	physical	18599455
BZR1_ARATH	BZR1	physical	12114546
BZR1_ARATH	BZR1	physical	12427989
BZR2_ARATH	BES1	physical	12427989
YODA_ARATH	YDA	physical	22307275
GCL1_ARATH	GCL1	physical	22737156
M2K4_ARATH	MKK4	physical	23341468
M2K5_ARATH	MKK5	physical	23341468
Y4523_ARATH	BSK1	physical	23496207
Y5126_ARATH	AT5G41260	physical	23496207
GBB_ARATH	AGB1	physical	23814276
HAT1_ARATH	HAT1	physical	24164091
EGL1_ARATH	EGL3	physical	24771765
WER_ARATH	MYB66	physical	24771765
TTG1_ARATH	TTG1	physical	24771765
BZR1_ARATH	BZR1	physical	21258370
SRK2D_ARATH	SNRK2.2	physical	24928519
SRK2I_ARATH	SNRK2.3	physical	24928519
SRK2E_ARATH	OST1	physical	24928519
BZR2_ARATH	BES1	physical	24928519
HS901_ARATH	HSP90.1	physical	24807419
HS903_ARATH	HSP81-3	physical	24807419
ARFG_ARATH	NPH4	physical	24362628
ARFS_ARATH	ARF19	physical	24362628
TDR_ARATH	PXY	physical	24362628
ABI5_ARATH	ABI5	physical	25415975
BZR2_ARATH	BES1	physical	12007405
U503A_ARATH	AT3G09070	genetic	26387715
U503A_ARATH	AT3G09070	physical	26387715
KSG7_ARATH	BIN2	physical	25969537

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.