HS903_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HS903_ARATH
• UniProt AC: P51818
• Protein Name: Heat shock protein 90-3 {ECO:0000305}
• Gene Name: HSP90-3 {ECO:0000303|PubMed:11599565}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 699
• Subcellular Localization: Cytoplasm .
• Protein Description: Functions as a holding molecular chaperone (holdase) which stabilizes unfolding protein intermediates and rapidly releases them in an active form once stress has abated. Functions as a folding molecular chaperone (foldase) that assists the non-covalent folding of proteins in an ATP-dependent manner. [PubMed: 23827697 Regulates RPP4-mediated temperature-dependent cell death and defense responses]
• Protein Sequence: MADAETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDALDKIRFESLTDKSKLDGQPELFIHIIPDKTNNTLTIIDSGIGMTKADLVNNLGTIARSGTKEFMEALAAGADVSMIGQFGVGFYSAYLVADKVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGEALGRGTKMVLYLKEDQMEYIEERRLKDLVKKHSEFISYPISLWIEKTIEKEISDDEEEEEKKDEEGKVEEVDEEKEKEEKKKKKIKEVSHEWDLVNKQKPIWMRKPEEINKEEYAAFYKSLSNDWEEHLAVKHFSVEGQLEFKAILFVPKRAPFDLFDTKKKPNNIKLYVRRVFIMDNCEDIIPEYLGFVKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCLELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNDIFYITGESKKAVENSPFLEKLKKKGIEVLYMVDAIDEYAIGQLKEFEGKKLVSATKEGLKLDETEDEKKKKEELKEKFEGLCKVIKDVLGDKVEKVIVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMGGYMSSKKTMEINPENSIMDELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGSRIHRMLKLGLSIDDDDVVEADADMPPLEDDADAEGSKMEEVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MADAETFAFQAEI --CCCHHHHHHHHHH	23.22	25368622
185	Phosphorylation	LKEDQMEYIEERRLK ECHHHHHHHHHHHHH	14.32	23820729
213	Phosphorylation	ISLWIEKTIEKEISD HHHHHHHHHHHHCCC	22.90	23776212
219	Phosphorylation	KTIEKEISDDEEEEE HHHHHHCCCCHHHHH	39.85	30291188
255	Phosphorylation	KKKIKEVSHEWDLVN HHHHHHHHHHHHHHC	19.44	30291188
286	Phosphorylation	EYAAFYKSLSNDWEE HHHHHHHHHCCCHHH	26.17	23776212
288	Phosphorylation	AAFYKSLSNDWEEHL HHHHHHHCCCHHHHH	39.57	30291188
476	Phosphorylation	SKKAVENSPFLEKLK CHHHHHCCHHHHHHH	11.97	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HS903_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HS903_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HS903_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS903_ARATH	HSP81-3	physical	23827697
KSG7_ARATH	BIN2	physical	24807419

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.