ARFS_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARFS_ARATH
• UniProt AC: Q8RYC8
• Protein Name: Auxin response factor 19
• Gene Name: ARF19
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1086
• Subcellular Localization: Nucleus .
• Protein Description: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Involved in ethylene responses. Regulates lateral root formation through direct regulation of LBD16 and/or LBD29. Functionally redundant with ARF7..
• Protein Sequence: MKAPSNGFLPSSNEGEKKPINSQLWHACAGPLVSLPPVGSLVVYFPQGHSEQVAASMQKQTDFIPNYPNLPSKLICLLHSVTLHADTETDEVYAQMTLQPVNKYDREALLASDMGLKLNRQPTEFFCKTLTASDTSTHGGFSVPRRAAEKIFPPLDFSMQPPAQEIVAKDLHDTTWTFRHIYRGQPKRHLLTTGWSVFVSTKRLFAGDSVLFVRDEKSQLMLGIRRANRQTPTLSSSVISSDSMHIGILAAAAHANANSSPFTIFFNPRASPSEFVVPLAKYNKALYAQVSLGMRFRMMFETEDCGVRRYMGTVTGISDLDPVRWKGSQWRNLQVGWDESTAGDRPSRVSIWEIEPVITPFYICPPPFFRPKYPRQPGMPDDELDMENAFKRAMPWMGEDFGMKDAQSSMFPGLSLVQWMSMQQNNPLSGSATPQLPSALSSFNLPNNFASNDPSKLLNFQSPNLSSANSQFNKPNTVNHISQQMQAQPAMVKSQQQQQQQQQQHQHQQQQLQQQQQLQMSQQQVQQQGIYNNGTIAVANQVSCQSPNQPTGFSQSQLQQQSMLPTGAKMTHQNINSMGNKGLSQMTSFAQEMQFQQQLEMHNSSQLLRNQQEQSSLHSLQQNLSQNPQQLQMQQQSSKPSPSQQLQLQLLQKLQQQQQQQSIPPVSSSLQPQLSALQQTQSHQLQQLLSSQNQQPLAHGNNSFPASTFMQPPQIQVSPQQQGQMSNKNLVAAGRSHSGHTDGEAPSCSTSPSANNTGHDNVSPTNFLSRNQQQGQAASVSASDSVFERASNPVQELYTKTESRISQGMMNMKSAGEHFRFKSAVTDQIDVSTAGTTYCPDVVGPVQQQQTFPLPSFGFDGDCQSHHPRNNLAFPGNLEAVTSDPLYSQKDFQNLVPNYGNTPRDIETELSSAAISSQSFGIPSIPFKPGCSNEVGGINDSGIMNGGGLWPNQTQRMRTYTKVQKRGSVGRSIDVTRYSGYDELRHDLARMFGIEGQLEDPLTSDWKLVYTDHENDILLVGDDPWEEFVNCVQNIKILSSVEVQQMSLDGDLAAIPTTNQACSETDSGNAWKVHYEDTSAAASFNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	QPKRHLLTTGWSVFV CCCCEEECCCCEEEE	29.62	19880383
193	Phosphorylation	PKRHLLTTGWSVFVS CCCEEECCCCEEEEE	36.30	19880383
200	Phosphorylation	TGWSVFVSTKRLFAG CCCEEEEEECCCCCC	19.42	19880383
201	Phosphorylation	GWSVFVSTKRLFAGD CCEEEEEECCCCCCC	18.19	19880383
1083	Phosphorylation	EDTSAAASFNR---- CCCCCHHHCCC----	20.51	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARFS_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARFS_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARFS_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IAA7_ARATH	IAA7	physical	21734647
IAA34_ARATH	IAA34	physical	21734647
IAA20_ARATH	IAA20	physical	21734647
IAA33_ARATH	IAA33	physical	21734647
ARFT_ARATH	ARF20	physical	21734647
IAA3_ARATH	SHY2	physical	21734647
IAA1_ARATH	IAA1	physical	21734647
IAA17_ARATH	AXR3	physical	21734647
IAA16_ARATH	IAA16	physical	21734647
IAA13_ARATH	IAA13	physical	21734647
IAA12_ARATH	IAA12	physical	21734647
IAA10_ARATH	IAA10	physical	21734647
IAA6_ARATH	IAA6	physical	25566309
IAA32_ARATH	IAA32	physical	25566309
IAA34_ARATH	IAA34	physical	25566309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.