YODA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YODA_ARATH
• UniProt AC: Q9CAD5
• Protein Name: Mitogen-activated protein kinase kinase kinase YODA
• Gene Name: YDA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 883
• Protein Description: Functions in a MAP kinase cascade that acts as a molecular switch to regulate the first cell fate decisions in the zygote and the early embryo. Promotes elongation of the zygote and development of its basal daughter cell into the extra-embryonic suspensor. In stomatal development, acts downstream of the LRR receptor TMM, but upstream of the MKK4/MKK5-MPK3/MPK6 module to regulate stomatal cell fate before the guard mother cell (GMC) is specified. Plays a central role in both guard cell identity and pattern formation. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the morphology of plant organs. Upon brassinosteroid signaling, is inhibited by phosphorylation of its auto-inhibitory N-terminal domain by the GSK3-like kinase ASK7..
• Protein Sequence: MPWWSKSKDEKKKTNKESIIDAFNRKLGFASEDRSSGRSRKSRRRRDEIVSERGAISRLPSRSPSPSTRVSRCQSFAERSPAVPLPRPIVRPHVTSTDSGMNGSQRPGLDANLKPSWLPLPKPHGATSIPDNTGAEPDFATASVSSGSSVGDIPSDSLLSPLASDCENGNRTPVNISSRDQSMHSNKNSAEMFKPVPNKNRILSASPRRRPLGTHVKNLQIPQRDLVLCSAPDSLLSSPSRSPMRSFIPDQVSNHGLLISKPYSDVSLLGSGQCSSPGSGYNSGNNSIGGDMATQLFWPQSRCSPECSPVPSPRMTSPGPSSRIQSGAVTPLHPRAGGSTTGSPTRRLDDNRQQSHRLPLPPLLISNTCPFSPTYSAATSPSVPRSPARAEATVSPGSRWKKGRLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHAKNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQSGPLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCTVLEMATTKPPWSQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAAQLLDHAFVRNVMPMERPIVSGEPAEAMNVASSTMRSLDIGHARSLPCLDSEDATNYQQKGLKHGSGFSISQSPRNMSCPISPVGSPIFHSHSPHISGRRSPSPISSPHALSGSSTPLTGCGGAIPFHHQRQTTVNFLHEGIGSSRSPGSGGNFYTNSFFQEPSRQQDRSRSSPRTPPHVFWDNNGSIQPGYNWNKDNQPVLSDHVSQQLLSEHLKLKSLDLRPGFSTPGSTNRGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	GAISRLPSRSPSPST CHHHCCCCCCCCCCC		29654922
63	Phosphorylation	ISRLPSRSPSPSTRV HHCCCCCCCCCCCCH		29654922
65	Phosphorylation	RLPSRSPSPSTRVSR CCCCCCCCCCCCHHH		25561503
67	Phosphorylation	PSRSPSPSTRVSRCQ CCCCCCCCCCHHHHH		25561503
68	Phosphorylation	SRSPSPSTRVSRCQS CCCCCCCCCHHHHHH		29654922
75	Phosphorylation	TRVSRCQSFAERSPA CCHHHHHHHHHHCCC		29654922
204	Phosphorylation	PNKNRILSASPRRRP CCCCCCCCCCCCCCC		29654922
206	Phosphorylation	KNRILSASPRRRPLG CCCCCCCCCCCCCCC		26811356
304	Phosphorylation	FWPQSRCSPECSPVP HCCCCCCCCCCCCCC		25561503
308	Phosphorylation	SRCSPECSPVPSPRM CCCCCCCCCCCCCCC		25561503
312	Phosphorylation	PECSPVPSPRMTSPG CCCCCCCCCCCCCCC		25561503
317	Phosphorylation	VPSPRMTSPGPSSRI CCCCCCCCCCCCHHC		29654922
322	Phosphorylation	MTSPGPSSRIQSGAV CCCCCCCHHCCCCCC		29654922
326	Phosphorylation	GPSSRIQSGAVTPLH CCCHHCCCCCCCCCC		30291188
330	Phosphorylation	RIQSGAVTPLHPRAG HCCCCCCCCCCCCCC		30291188
339	Phosphorylation	LHPRAGGSTTGSPTR CCCCCCCCCCCCCCC		29654922
340	Phosphorylation	HPRAGGSTTGSPTRR CCCCCCCCCCCCCCC		25561503
341	Phosphorylation	PRAGGSTTGSPTRRL CCCCCCCCCCCCCCC		25561503
343	Phosphorylation	AGGSTTGSPTRRLDD CCCCCCCCCCCCCCC		25561503
345	Phosphorylation	GSTTGSPTRRLDDNR CCCCCCCCCCCCCCC		29654922
395	Phosphorylation	ARAEATVSPGSRWKK CCCCCEECCCCCCCC		25561503
558	Phosphorylation	TAQSGPLSFKGSPYW ECCCCCCCCCCCCCE		25561503
668	Phosphorylation	PMERPIVSGEPAEAM CCCCCCCCCCCHHHH		22074104
713	Phosphorylation	QKGLKHGSGFSISQS HHCCCCCCCCCCCCC		25561503
716	Phosphorylation	LKHGSGFSISQSPRN CCCCCCCCCCCCCCC		29654922
718	Phosphorylation	HGSGFSISQSPRNMS CCCCCCCCCCCCCCC		25561503
720	Phosphorylation	SGFSISQSPRNMSCP CCCCCCCCCCCCCCC		29654922
780	Phosphorylation	PFHHQRQTTVNFLHE CCCCCCCCCEEEEEC		25561503
781	Phosphorylation	FHHQRQTTVNFLHEG CCCCCCCCEEEEECC		29654922
794	Phosphorylation	EGIGSSRSPGSGGNF CCCCCCCCCCCCCCC		30407730
797	Phosphorylation	GSSRSPGSGGNFYTN CCCCCCCCCCCCCCC		30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YODA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YODA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YODA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KSG7_ARATH	BIN2	physical	22307275

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.