ARFB_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARFB_ARATH
• UniProt AC: Q94JM3
• Protein Name: Auxin response factor 2
• Gene Name: ARF2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 859
• Subcellular Localization: Nucleus.
• Protein Description: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Functions independently of ethylene and cytokinin response pathways. May act as a repressor of cell division and organ growth..
• Protein Sequence: MASSEVSMKGNRGGDNFSSSGFSDPKETRNVSVAGEGQKSNSTRSAAAERALDPEAALYRELWHACAGPLVTVPRQDDRVFYFPQGHIEQVEASTNQAAEQQMPLYDLPSKLLCRVINVDLKAEADTDEVYAQITLLPEANQDENAIEKEAPLPPPPRFQVHSFCKTLTASDTSTHGGFSVLRRHADECLPPLDMSRQPPTQELVAKDLHANEWRFRHIFRGQPRRHLLQSGWSVFVSSKRLVAGDAFIFLRGENGELRVGVRRAMRQQGNVPSSVISSHSMHLGVLATAWHAISTGTMFTVYYKPRTSPSEFIVPFDQYMESVKNNYSIGMRFKMRFEGEEAPEQRFTGTIVGIEESDPTRWPKSKWRSLKVRWDETSSIPRPDRVSPWKVEPALAPPALSPVPMPRPKRPRSNIAPSSPDSSMLTREGTTKANMDPLPASGLSRVLQGQEYSTLRTKHTESVECDAPENSVVWQSSADDDKVDVVSGSRRYGSENWMSSARHEPTYTDLLSGFGTNIDPSHGQRIPFYDHSSSPSMPAKRILSDSEGKFDYLANQWQMIHSGLSLKLHESPKVPAATDASLQGRCNVKYSEYPVLNGLSTENAGGNWPIRPRALNYYEEVVNAQAQAQAREQVTKQPFTIQEETAKSREGNCRLFGIPLTNNMNGTDSTMSQRNNLNDAAGLTQIASPKVQDLSDQSKGSKSTNDHREQGRPFQTNNPHPKDAQTKTNSSRSCTKVHKQGIALGRSVDLSKFQNYEELVAELDRLFEFNGELMAPKKDWLIVYTDEENDMMLVGDDPWQEFCCMVRKIFIYTKEEVRKMNPGTLSCRSEEEAVVGEGSDAKDAKSASNPSLSSAGNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MASSEVSMKGNRGG -CCCCCCCCCCCCCC	15.66	19880383
419	Phosphorylation	PRSNIAPSSPDSSML CCCCCCCCCCCCCCC	45.54	19880383
420	Phosphorylation	RSNIAPSSPDSSMLT CCCCCCCCCCCCCCC	31.50	19880383
423	Phosphorylation	IAPSSPDSSMLTREG CCCCCCCCCCCCCCC	22.49	25561503
424	Phosphorylation	APSSPDSSMLTREGT CCCCCCCCCCCCCCC	25.78	25561503
427	Phosphorylation	SPDSSMLTREGTTKA CCCCCCCCCCCCCCC	20.31	25561503
533	Phosphorylation	RIPFYDHSSSPSMPA CCCCCCCCCCCCCCC	29.61	23111157
535	Phosphorylation	PFYDHSSSPSMPAKR CCCCCCCCCCCCCHH	24.82	25561503
685	Phosphorylation	LNDAAGLTQIASPKV CHHHCCHHHHCCCCH	19.60	30407730
689	Phosphorylation	AGLTQIASPKVQDLS CCHHHHCCCCHHCCC	27.21	30291188
825	Phosphorylation	VRKMNPGTLSCRSEE HHCCCCCCCCCCCCC	19.43	19880383
827	Phosphorylation	KMNPGTLSCRSEEEA CCCCCCCCCCCCCEE	13.81	19880383
840	Phosphorylation	EAVVGEGSDAKDAKS EEECCCCCCHHHHHH	30.05	23111157
847	Phosphorylation	SDAKDAKSASNPSLS CCHHHHHHCCCCCCH	38.35	25561503
849	Phosphorylation	AKDAKSASNPSLSSA HHHHHHCCCCCCHHC	57.26	25561503
852	Phosphorylation	AKSASNPSLSSAGNS HHHCCCCCCHHCCCC	45.17	25561503
854	Phosphorylation	SASNPSLSSAGNS-- HCCCCCCHHCCCC--	23.60	25561503
855	Phosphorylation	ASNPSLSSAGNS--- CCCCCCHHCCCC---	45.55	25561503
859	Phosphorylation	SLSSAGNS------- CCHHCCCC-------	40.45	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARFB_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARFB_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARFB_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IAA32_ARATH	IAA32	physical	21734647
IAA34_ARATH	IAA34	physical	21734647
IAA13_ARATH	IAA13	physical	25566309
IAA15_ARATH	IAA15	physical	25566309
IAA32_ARATH	IAA32	physical	25566309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.