SCAR2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCAR2_ARATH
• UniProt AC: Q5XPJ9
• Protein Name: Protein SCAR2
• Gene Name: SCAR2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1399
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion..
• Protein Sequence: MPLTRYQSRNEYGLADPDLYQAADKDDPEALLEGVAMAGLVGILRQLGDLAEFAAEMFHDLHEEVMATASRSHGLMARVQQLEAEFPSIEKALLCQTDHSPFFSNKGVEWHPNLQLEQSVVTSGDLPRCVMDSYEECRGPPRLFLLDKFDISGAGACLKRYTDPSFVRLETSSYEESWDDIQREKKSQKAKRRASQWRNGGTPENALSSHAKLHELFLEEHLEAHHSDPARVVKLKTRKLDGCSLISKSGESYMEKFVQTRVDSKISYEIITQNPGLLTWNMDSARDVVTDIPEISMVGAMDKSHGGSRAEVSFPSEQENVANVNMNGGFIEKDIETVPESTYNEVRGTTITQDSQTVLNGKPGFFQQRSYSEDLTSEADNYVDAPATMESETETDDECRPKSRSDTLKDGNHHIYSDAVEERMEDPPQFSFSHSNGNTPVSENGRSSFGKKSTSYSYSDTASISIDDQSDGEKLSGCLPSTSSFKSELVDSMSHVTPEANKVSHDLNVQESVSSSNVDGQTSLSSNGTCSSPRPVSQNDQSCSLTVQSLASEVVETSPELVRLDLMKGGNDGRKVDPFDSSKSCASFDAKNSDLPSETSSISSTSEGSRCDSTIEKNCMVASNLVNSGTSPQAFVDSQTGKQLPIADTDFETNSIVACSEVLANSGSDPEERDGRCLTGKLVPCSAGVGMEVSPDTPSKVCGPSSADGIHLKDTLDDETDCVSVTNVVVDVDSKNSVADVGSQSSVADIDSQSSVAEISDEHSCAFGNTADVSVSESHEDTLENGMSVPSDFNSGVEKLAGDASPTCSKCDDHISHEGFHDLSGLDNATTDIVPNVELDVSDNDNDTSSGGVNHAVSLSSTRGKGSLPWISTNTYQSSSDAGEIFHDTVVESDGTLLEDNNPESEIKMHKSPLEVSSEGLSTEPDNKDVESIESTSPKPSLDQRNRDTETKSPGESILDDNCIDSTQVYNLNLLESEAIDQAVREQTSYASHEVADEELLQSNVFRGLEFEPQSAGLEFAPQSAGIELNRPKQELNLDPTFPSFGFIPETIPPNPEDMPPLPPMQWLIGKVPHSFPTFMGESVETSSSALSAAPPIGSSLNVQIGSPPSELSVSLGSDESERLPGGFVHNASEKPLQSSIQFPTMSTDLNSQYDSSELPTIPYQECIEDFGSEENNLLADHAAQNHELVYSQASSLQLPQVKHEDFKDDADVHESQSSSDDHHCPETKSLTPTQSTKVEDKGHSVPDASNAETAESSNTSVQKINPVSVGDAMWPVSCFSVAPTLDTYKTEVVPTVRLPRPRSPLVDAVAAHDRRKMKKVSEMVHPPIKSKQDDKDSLLAQIRNKSVNLKPAVTTRPSIQTGPRTDLRVAAILEKANTIRMAMAGSDEDEDSDSWSDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
202	Phosphorylation	SQWRNGGTPENALSS HHHHCCCCHHHHHHH	28.91	25561503
484	Phosphorylation	GCLPSTSSFKSELVD CCCCCCHHHHHHHHH	36.46	25561503
584	Phosphorylation	DPFDSSKSCASFDAK CCCCCCCCCHHCCCC	19.50	25561503
587	Phosphorylation	DSSKSCASFDAKNSD CCCCCCHHCCCCCCC	28.17	25561503
605	Phosphorylation	ETSSISSTSEGSRCD CCCCCCCCCCCCCCC	24.81	19880383
606	Phosphorylation	TSSISSTSEGSRCDS CCCCCCCCCCCCCCC	41.74	19880383
609	Phosphorylation	ISSTSEGSRCDSTIE CCCCCCCCCCCCHHH	26.19	19880383
720	Phosphorylation	KDTLDDETDCVSVTN CCCCCCCCCCEEEEE	41.51	19880383
724	Phosphorylation	DDETDCVSVTNVVVD CCCCCCEEEEEEEEE	29.56	23572148
726	Phosphorylation	ETDCVSVTNVVVDVD CCCCEEEEEEEEECC	18.13	23572148
805	Phosphorylation	EKLAGDASPTCSKCD HHHCCCCCCCCHHCC	26.02	23776212
807	Phosphorylation	LAGDASPTCSKCDDH HCCCCCCCCHHCCCC	27.24	23776212
809	Phosphorylation	GDASPTCSKCDDHIS CCCCCCCHHCCCCCC	38.50	23776212
932	Phosphorylation	PDNKDVESIESTSPK CCCCCHHHHHCCCCC	31.35	30407730
935	Phosphorylation	KDVESIESTSPKPSL CCHHHHHCCCCCCCH	32.30	30407730
936	Phosphorylation	DVESIESTSPKPSLD CHHHHHCCCCCCCHH	35.94	30407730
937	Phosphorylation	VESIESTSPKPSLDQ HHHHHCCCCCCCHHH	39.96	19880383
941	Phosphorylation	ESTSPKPSLDQRNRD HCCCCCCCHHHCCCC	51.18	30407730
1304	Phosphorylation	VRLPRPRSPLVDAVA CCCCCCCCHHHHHHH	25.85	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCAR2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCAR2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCAR2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARPC3_ARATH	ARPC3	physical	15659634
RAC2_ARATH	RAC2	physical	17267444
RAC6_ARATH	RAC6	physical	17267444
RAC9_ARATH	ARAC9	physical	17267444
RAC4_ARATH	ROP2	physical	17267444

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.