P2C16_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P2C16_ARATH
• UniProt AC: Q9CAJ0
• Protein Name: Protein phosphatase 2C 16
• Gene Name: HAB1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 511
• Subcellular Localization: Cytoplasm . Nucleus . Mainly cytoplasmic.
• Protein Description: Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought..
• Protein Sequence: MEEMTPAVAMTLSLAANTMCESSPVEITQLKNVTDAADLLSDSENQSFCNGGTECTMEDVSELEEVGEQDLLKTLSDTRSGSSNVFDEDDVLSVVEDNSAVISEGLLVVDAGSELSLSNTAMEIDNGRVLATAIIVGESSIEQVPTAEVLIAGVNQDTNTSEVVIRLPDENSNHLVKGRSVYELDCIPLWGTVSIQGNRSEMEDAFAVSPHFLKLPIKMLMGDHEGMSPSLTHLTGHFFGVYDGHGGHKVADYCRDRLHFALAEEIERIKDELCKRNTGEGRQVQWDKVFTSCFLTVDGEIEGKIGRAVVGSSDKVLEAVASETVGSTAVVALVCSSHIVVSNCGDSRAVLFRGKEAMPLSVDHKPDREDEYARIENAGGKVIQWQGARVFGVLAMSRSIGDRYLKPYVIPEPEVTFMPRSREDECLILASDGLWDVMNNQEVCEIARRRILMWHKKNGAPPLAERGKGIDPACQAAADYLSMLALQKGSKDNISIIVIDLKAQRKFKTRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	ITQLKNVTDAADLLS EEECCCCCCHHHHCC	29.34	23776212
41	Phosphorylation	TDAADLLSDSENQSF CCHHHHCCCCCCCCC	46.52	23776212
43	Phosphorylation	AADLLSDSENQSFCN HHHHCCCCCCCCCCC	34.76	23776212
47	Phosphorylation	LSDSENQSFCNGGTE CCCCCCCCCCCCCCC	43.26	23776212
53	Phosphorylation	QSFCNGGTECTMEDV CCCCCCCCCCCCCCH	29.32	23776212
56	Phosphorylation	CNGGTECTMEDVSEL CCCCCCCCCCCHHHH	19.84	23776212
61	Phosphorylation	ECTMEDVSELEEVGE CCCCCCHHHHHHHCH	49.11	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BPM3	O22286	PMID:31308219
-	K	Ubiquitination	E3 ubiquitin ligase	BPM5	Q1EBV6	PMID:31308219

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P2C16_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P2C16_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRK2E_ARATH	OST1	physical	19855047
PYR1_ARATH	PYR1	physical	22829320
PYL1_ARATH	PYL1	physical	22829320
PYL2_ARATH	PYL2	physical	22829320
PYL3_ARATH	PYL3	physical	22829320
PYL4_ARATH	PYL4	physical	22829320
PYL5_ARATH	PYL5	physical	22829320
PYL6_ARATH	PYL6	physical	22829320
PYL7_ARATH	PYL7	physical	22829320
PYL8_ARATH	RCAR3	physical	22829320
PYL9_ARATH	RCAR1	physical	22829320
PYL10_ARATH	PYL10	physical	22829320
PYL11_ARATH	PYL11	physical	22829320
PYL12_ARATH	PYL12	physical	22829320
MBP_HUMAN	MBP	physical	22968126
PYL4_ARATH	PYL4	physical	24823379
PYR1_ARATH	PYR1	physical	24823379
SRK2E_ARATH	OST1	physical	22516825
SRK2D_ARATH	SNRK2.2	physical	22516825
SRK2I_ARATH	SNRK2.3	physical	22516825
SRK2H_ARATH	SNRK2.5	physical	22516825
SRK2F_ARATH	SNRK2.7	physical	22516825
PYL9_ARATH	RCAR1	physical	19407143
SRK2E_ARATH	OST1	physical	19898420
PYL2_ARATH	PYL2	physical	19898420
SRK2E_ARATH	OST1	physical	20729862
SRK2D_ARATH	SNRK2.2	physical	22116026
SRK2I_ARATH	SNRK2.3	physical	22116026
SRK2E_ARATH	OST1	physical	22116026
PYL2_ARATH	PYL2	physical	23290725
PYL5_ARATH	PYL5	physical	19624469
PYL8_ARATH	RCAR3	physical	19624469
PYL6_ARATH	PYL6	physical	19624469
SWI3B_ARATH	SWI3B	physical	19033529

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.