P2C37_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P2C37_ARATH
• UniProt AC: P49598
• Protein Name: Protein phosphatase 2C 37
• Gene Name: PP2CA
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 399
• Protein Description: Major negative regulator of abscisic acid (ABA) responses during seed germination and cold acclimation. Confers insensitivity to ABA. Modulates negatively the AKT2/3 activity, which mediates K(+) transport and membrane polarization during stress situations, probably by dephosphorylation. Prevents stomata closure by inactivating the S-type anion efflux channel SLAC1 and its activator SRK2E..
• Protein Sequence: MAGICCGVVGETEPAAPVDSTSRASLRRRLDLLPSIKIVADSAVAPPLENCRKRQKRETVVLSTLPGNLDLDSNVRSENKKARSAVTNSNSVTEAESFFSDVPKIGTTSVCGRRRDMEDAVSIHPSFLQRNSENHHFYGVFDGHGCSHVAEKCRERLHDIVKKEVEVMASDEWTETMVKSFQKMDKEVSQRECNLVVNGATRSMKNSCRCELQSPQCDAVGSTAVVSVVTPEKIIVSNCGDSRAVLCRNGVAIPLSVDHKPDRPDELIRIQQAGGRVIYWDGARVLGVLAMSRAIGDNYLKPYVIPDPEVTVTDRTDEDECLILASDGLWDVVPNETACGVARMCLRGAGAGDDSDAAHNACSDAALLLTKLALARQSSDNVSVVVVDLRKRRNNQASS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	RRLDLLPSIKIVADS HHHHCCCCCEEEECC	36.16	25561503
180	Phosphorylation	WTETMVKSFQKMDKE HHHHHHHHHHHHCHH	22.84	24894044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BPM3	O22286	PMID:31308219
-	K	Ubiquitination	E3 ubiquitin ligase	BPM5	Q1EBV6	PMID:31308219

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P2C37_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P2C37_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT2_ARATH	KT2/3	physical	11181729
AKT2_ARATH	KT2/3	physical	12034902
CIPK6_ARATH	SIP3	physical	21596690
CIPK1_ARATH	CIPK1	physical	21596690
CNBL1_ARATH	CBL1	physical	21596690
CNBL2_ARATH	CBL2	physical	21596690
CNBL3_ARATH	CBL3	physical	21596690
CNBL5_ARATH	CBL5	physical	21596690
CNBL7_ARATH	CBL7	physical	21596690
SRK2E_ARATH	OST1	physical	23864556
AI5L5_ARATH	ABF2	physical	23864556
ABI5_ARATH	ABI5	physical	23864556
KIN10_ARATH	KIN10	physical	24179127
PYL13_ARATH	PYL13	physical	24189045
BCAT2_ARATH	BCAT-2	physical	24823379
AFP2_ARATH	AFP2	physical	24823379
CIPKB_ARATH	SIP4	physical	24823379
PYL4_ARATH	PYL4	physical	24823379
AFP4_ARATH	TMAC2	physical	24823379
PYR1_ARATH	PYR1	physical	24823379
HA22D_ARATH	HVA22D	physical	24823379
NADB_ARATH	AO	physical	24823379
RVE2_ARATH	RVE2	physical	24823379
EF105_ARATH	AT5G51190	physical	24823379
PYL8_ARATH	RCAR3	physical	24823379
P2C78_ARATH	HAI1	physical	24823379
SRK2D_ARATH	SNRK2.2	physical	19407142
SRK2I_ARATH	SNRK2.3	physical	23007729
SRK2D_ARATH	SNRK2.2	physical	23007729
CDPKB_ARATH	CDPK2	physical	23007729
PYL9_ARATH	RCAR1	physical	22935148
PYL7_ARATH	PYL7	physical	22935148
PYL8_ARATH	RCAR3	physical	22935148
PYL10_ARATH	PYL10	physical	22935148
PYL11_ARATH	PYL11	physical	22935148
PYL12_ARATH	PYL12	physical	22935148
PYL13_ARATH	PYL13	physical	22935148
PYL5_ARATH	PYL5	physical	22935148
PYL6_ARATH	PYL6	physical	22935148
PYL4_ARATH	PYL4	physical	22935148
PYL3_ARATH	PYL3	physical	22935148
SLAC1_ARATH	OZS1	physical	22935148
SWI3B_ARATH	SWI3B	physical	19033529

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.