| UniProt ID | CIPK6_ARATH | |
|---|---|---|
| UniProt AC | O65554 | |
| Protein Name | CBL-interacting serine/threonine-protein kinase 6 | |
| Gene Name | CIPK6 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 441 | |
| Subcellular Localization | Endoplasmic reticulum . Targeted to the cell membrane when interacting with CBL4 and ATK2. | |
| Protein Description | CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1. Binds to CBL4 to modulate AKT2 activity by promoting a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane.. | |
| Protein Sequence | MVGAKPVENGSDGGSSTGLLHGRYELGRLLGHGTFAKVYHARNIQTGKSVAMKVVGKEKVVKVGMVDQIKREISVMRMVKHPNIVELHEVMASKSKIYFAMELVRGGELFAKVAKGRLREDVARVYFQQLISAVDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLSAFTEHLKQDGLLHTTCGTPAYVAPEVILKKGYDGAKADLWSCGVILFVLLAGYLPFQDDNLVNMYRKIYRGDFKCPGWLSSDARRLVTKLLDPNPNTRITIEKVMDSPWFKKQATRSRNEPVAATITTTEEDVDFLVHKSKEETETLNAFHIIALSEGFDLSPLFEEKKKEEKREMRFATSRPASSVISSLEEAARVGNKFDVRKSESRVRIEGKQNGRKGKLAVEAEIFAVAPSFVVVEVKKDHGDTLEYNNFCSTALRPALKDIFWTSTPA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | Phosphorylation | GRLLGHGTFAKVYHA HHHHCCCCEEEEEEE | 18.10 | 19880383 | |
| 168 | Phosphorylation | KVTDFGLSAFTEHLK EECCCCHHHHHHHHH | 23.01 | - | |
| 182 | Phosphorylation | KQDGLLHTTCGTPAY HHCCCCCCCCCCCCC | 24.61 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CIPK6_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CIPK6_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CIPK6_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CNBL3_ARATH | CBL3 | physical | 11115898 | |
| CNBL1_ARATH | CBL1 | physical | 11115898 | |
| CNBL4_ARATH | SOS3 | physical | 11115898 | |
| AKT1_ARATH | KT1 | physical | 17898163 | |
| CNBL1_ARATH | CBL1 | physical | 17898163 | |
| CNBL2_ARATH | CBL2 | physical | 17898163 | |
| CNBL3_ARATH | CBL3 | physical | 17898163 | |
| CNBL9_ARATH | CBL9 | physical | 17898163 | |
| CNBL4_ARATH | SOS3 | physical | 24970010 | |
| CNBL4_ORYSJ | Os05g0534400 | physical | 24970010 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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